Anti-CCR9 抗体 (ab1662)
製品の概要
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製品名
Anti-CCR9 antibody
CCR9 一次抗体 製品一覧 -
製品の詳細
Goat polyclonal to CCR9 -
由来種
Goat -
特異性
Peptide sequence is < 50 % identical to other mouse chemokine receptors in this region. -
アプリケーション
適用あり: IHC-FoFr, Flow Cyt, ELISA, IHC-P, WBmore details -
種交差性
交差種: Mouse
交差が予測される動物種: Human -
免疫原
Synthetic peptide:
IPGMFDDFSYDSTASTDDYMNLNFSSFF
, corresponding to amino acids 10-37 of Mouse CCR9. -
ポジティブ・コントロール
- Mouse thymus or lymphnodes.
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
Preservative: 0.1% Sodium azide
Constituent: 0.1% BSA -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
Our Abpromise guarantee covers the use of ab1662 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
アプリケーション | Abreviews | 特記事項 |
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IHC-FoFr | 1/500 - 1/1000. After perfusion place in 30% sucrose overnight. | |
Flow Cyt | 1/200. ab37373 - Goat polyclonal IgG, is suitable for use as an isotype control with this antibody.
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ELISA | 1/100000. | |
IHC-P | 1/250. | |
WB | 1/1000. |
ターゲット情報
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関連性
The protein encoded by this gene is a member of the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein coupled receptors. Chemokines and their receptors are key regulators of the thymocytes migration and maturation in normal and inflammation conditions. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. The specific ligand of this receptor is CCL25. It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon, suggested a role in the thymocytes recruitment and development that may permit functional specialization of immune responses in different segment of the gastrointestinal tract. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes. Two alternatively spliced transcript variants have been described. -
細胞内局在
Cell membrane; Multi-pass membrane protein. -
参照データベース
- Entrez Gene: 10803 Human
- Entrez Gene: 12769 Mouse
- Omim: 604738 Human
- SwissProt: P51686 Human
- SwissProt: Q9WUT7 Mouse
- Unigene: 225946 Human
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別名
- C C chemokine receptor D6 antibody
- C C chemokine receptor type 9 antibody
- C C CKR 9 antibody
see all
画像
参考文献
This product has been referenced in:
- Huang Y et al. Abrogation of CC chemokine receptor 9 ameliorates ventricular remodeling in mice after myocardial infarction. Sci Rep 6:32660 (2016). Read more (PubMed: 27585634) »
- Chu PS et al. C-C motif chemokine receptor 9 positive macrophages activate hepatic stellate cells and promote liver fibrosis in mice. Hepatology 58:337-50 (2013). Read more (PubMed: 23460364) »