Anti-CBX2 抗体 (ab264295)
Key features and details
- Rabbit polyclonal to CBX2
- Suitable for: IP
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-CBX2 antibody
CBX2 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to CBX2 -
由来種
Rabbit -
アプリケーション
適用あり: IPmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse -
免疫原
Synthetic peptide within Human CBX2 aa 482-532. The exact sequence is proprietary. NP_005180.1
Database link: Q14781 -
ポジティブ・コントロール
- IP: HEK-293T whole cell lysate.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7
Preservative: 0.09% Sodium azide
Constituent: Tris citrate/phosphate
pH 7 to 8 -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab264295の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IP |
Use at 2-10 µg/mg of lysate.
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特記事項 |
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IP
Use at 2-10 µg/mg of lysate. |
ターゲット情報
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機能
Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Involved in sexual development, acting as activator of NR5A1 expression. -
関連疾患
Defects in CBX2 are the cause of 46,XY sex reversal type 5 (SRXY5) [MIM:613080]. It is a disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females. -
配列類似性
Contains 1 A.T hook DNA-binding domain.
Contains 1 chromo domain. -
細胞内局在
Nucleus. - Information by UniProt
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参照データベース
- Entrez Gene: 84733 Human
- Entrez Gene: 12416 Mouse
- Omim: 602770 Human
- SwissProt: Q14781 Human
- SwissProt: P30658 Mouse
- Unigene: 368410 Human
- Unigene: 14547 Mouse
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別名
- Cbx 2 antibody
- CBX2 antibody
- CBX2_HUMAN antibody
see all
画像
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CBX2 was immunoprecipitated from 1mg of HEK-293T (Human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate with ab264295 at 6 µg per reaction. Western blot was performed from the immunoprecipitate using ab264295 at 1 µg/ml.
Lane 1: ab264295 IP in HEK-293T whole cell lysate.
Lane 2: ab264295 IP in HEK-293T whole cell lysate.
Lane 3: ab264295 IP in HEK-293T whole cell lysate.
Lane 4: Control IgG.
Exposure time: 30 secs.
Cells prepared using NETN lysis buffer.
Different lots were used in lane 1, lane 2 and lane 3.
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (0)
ab264295 は論文での使用が確認できていません。