Anti-Caveolin-2 抗体 (ab2911)
Key features and details
- Rabbit polyclonal to Caveolin-2
- Suitable for: WB
- Reacts with: Mouse, Rat
- Isotype: IgG
製品の概要
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製品名
Anti-Caveolin-2 antibody
Caveolin-2 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Caveolin-2 -
由来種
Rabbit -
特異性
Detects caveolin-2 from rat tissues. This antibody does not detect caveolin-1 or -3. -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Mouse, Rat
交差が予測される動物種: Sheep, Rabbit, Cow, Cat, Pig, Chimpanzee, Gorilla, African green monkey, African bush elephant
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免疫原
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
Preservative: 0.05% Sodium azide
Constituents: 0.1% BSA, 99% PBS -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Immunizing Peptide (Blocking)
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Isotype control
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Recombinant Protein
アプリケーション
Our Abpromise guarantee covers the use of ab2911 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB | Use at an assay dependent concentration. Can be blocked with Caveolin-2 peptide (ab4929). Can be blocked with Caveolin-2 peptide. |
ターゲット情報
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機能
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression. -
組織特異性
Expressed in endothelial cells, smooth muscle cells, skeletal myoblasts and fibroblasts. -
配列類似性
Belongs to the caveolin family. -
翻訳後修飾
Phosphorylated on serine and tyrosine residues. CAV1 promotes phosphorylation on Ser-23 which then targets the complex to the plasma membrane, lipid rafts and caveolae. Phosphorylation on Ser-36 appears to modulate mitosis in endothelial cells (By similarity). Phosphorylation on both Tyr-19 and Tyr-27 is required for insulin-induced 'Ser-727' phosphorylation of STAT3 and its activation. Phosphorylation on Tyr-19 is required for insulin-induced phosphorylation of MAPK1 and DNA binding of STAT3. Tyrosine phosphorylation is induced by both EGF and insulin. -
細胞内局在
Nucleus. Cytoplasm. Golgi apparatus membrane. Cell membrane. Membrane > caveola. Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Tyr-19-phosphorylated form is enriched at sites of cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin (By similarity). Tyr-27-phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1-mediated Ser-23-phosphorylated form locates to the plasma membrane. Ser-36-phosphorylated form resides in intracellular compartments. - Information by UniProt
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参照データベース
- Entrez Gene: 12390 Mouse
- Entrez Gene: 100362824 Rat
- Entrez Gene: 363425 Rat
- SwissProt: Q9WVC3 Mouse
- SwissProt: Q2IBC5 Rat
- Unigene: 396075 Mouse
- Unigene: 81070 Rat
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別名
- CAV antibody
- CAV2 antibody
- CAV2_HUMAN antibody
see all
画像
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Western blot - Anti-Caveolin-2 antibody (ab2911)Western blot of caveolin-2 on rat skeletal muscle protein extract using ab2911.
プロトコール
データシートおよび資料
参考文献 (9)
ab2911 は 9 報の論文で使用されています。
- Russell JS et al. Cardiomyoblast caveolin expression: Effects of simulated diabetes, a-linolenic acid and cell signaling pathways. Am J Physiol Cell Physiol N/A:N/A (2020). PubMed: 32348174
- Mortensen OV et al. MAP Kinase Phosphatase 3 (MKP3) Preserves Norepinephrine Transporter Activity by Modulating ERK1/2 Kinase-Mediated Gene Expression. Front Cell Neurosci 11:253 (2017). PubMed: 28878626
- Hoeke L et al. Intestinal Salmonella typhimurium infection leads to miR-29a induced caveolin 2 regulation. PLoS One 8:e67300 (2013). WB . PubMed: 23826261
- Cho WJ et al. Caveolin-1 exists and may function in cardiomyocytes. Can J Physiol Pharmacol 88:73-6 (2010). IHC-P ; Mouse . PubMed: 20130741
- Källquist L et al. Neutrophil elastase and proteinase 3 trafficking routes in myelomonocytic cells. Exp Cell Res 316:3182-96 (2010). PubMed: 20828556
- Zaas DW et al. Counteracting Signaling Activities in Lipid Rafts Associated with the Invasion of Lung Epithelial Cells by Pseudomonas aeruginosa. J Biol Chem 284:9955-64 (2009). WB ; Mouse . PubMed: 19211560
- Cho WJ et al. Matrix metalloproteinase-2, caveolins, focal adhesion kinase and c-Kit in cells of the mouse myocardium. J Cell Mol Med 11:1069-86 (2007). PubMed: 17979883
- Shu L & Shayman JA Caveolin-associated accumulation of globotriaosylceramide in the vascular endothelium of alpha-galactosidase A null mice. J Biol Chem 282:20960-7 (2007). WB ; Mouse . PubMed: 17535804
- Zaas DW et al. Pseudomonas invasion of type I pneumocytes is dependent on the expression and phosphorylation of caveolin-2. J Biol Chem 280:4864-72 (2005). PubMed: 15545264
