Anti-Cathepsin K 抗体 (ab19027)
Key features and details
- Rabbit polyclonal to Cathepsin K
- Suitable for: IHC-P, ICC/IF, IHC-Fr, WB
- Reacts with: Mouse, Rat, Human, Zebrafish
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-Cathepsin K antibody
Cathepsin K 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Cathepsin K -
由来種
Rabbit -
アプリケーション
適用あり: IHC-P, ICC/IF, IHC-Fr, WBmore details -
種交差性
交差種: Mouse, Rat, Human, Zebrafish -
免疫原
Synthetic peptide, corresponding to a region within amino acids 300-329 of Rat Cathepsin K which includes residue 321. (Peptide available as ab41720.)
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ポジティブ･コントロール
- WB: Rat kidney tissue lysate
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特記事項
This product is manufactured by BioVision, an Abcam company and was previously called 3588 Cathepsin K Antibody. 3588-100 is the same size as the 100 µg size of ab19027.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
Preservative: 0.03% Proclin 300
Constituents: PBS, 30% Glycerol (glycerin, glycerine), 0.5% BSA, 0.015% EDTA -
Concentration information loading... -
精製度
Protein A purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Assay kits
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Compatible Secondaries
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Isotype control
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Recombinant Protein
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Related Products
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab19027の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| IHC-P | (3) |
Use at an assay dependent concentration.
|
| ICC/IF | (5) |
Use at an assay dependent concentration.
|
| IHC-Fr | (2) |
Use at an assay dependent concentration.
|
| WB | (6) |
Use a concentration of 0.5 - 4 µg/ml. Predicted molecular weight: 37 kDa.
|
| 特記事項 |
|---|
|
IHC-P
Use at an assay dependent concentration. |
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ICC/IF
Use at an assay dependent concentration. |
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IHC-Fr
Use at an assay dependent concentration. |
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WB
Use a concentration of 0.5 - 4 µg/ml. Predicted molecular weight: 37 kDa. |
ターゲット情報
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機能
Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. -
組織特異性
Predominantly expressed in osteclasts (bones). -
関連疾患
Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:265800]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature. -
配列類似性
Belongs to the peptidase C1 family. -
細胞内局在
Lysosome. - Information by UniProt
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参照データベース
- Entrez Gene: 1513 Human
- Entrez Gene: 13038 Mouse
- Entrez Gene: 29175 Rat
- Omim: 601105 Human
- SwissProt: P43235 Human
- SwissProt: P55097 Mouse
- SwissProt: O35186 Rat
- Unigene: 632466 Human
see all -
別名
- Cathepsin K antibody
- Cathepsin O antibody
- Cathepsin O1 antibody
see all
画像
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Western blot - Anti-Cathepsin K antibody (ab19027)Anti-Cathepsin K antibody (ab19027) + Rat kidney tissue lysate
Predicted band size: 37 kDa
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (120)
ab19027 は 120 報の論文で使用されています。
- Kayalar E et al. Effect of salvianolic acid B on new bone formation in the orthopedically expanded suture. Angle Orthod 91:248-254 (2021). PubMed: 33367542
- Tian Y et al. Melatonin inhibits RANKL-induced osteoclastogenesis through the miR-882/Rev-erba axis in Raw264.7 cells. Int J Mol Med 47:633-642 (2021). PubMed: 33416111
- Heo SC et al. Elevated Expression of Cathepsin K in Periodontal Ligament Fibroblast by Inflammatory Cytokines Accelerates Osteoclastogenesis via Paracrine Mechanism in Periodontal Disease. Int J Mol Sci 22:N/A (2021). PubMed: 33445732
- Inagaki Y et al. Gan-Lu-Yin (Kanroin), Traditional Chinese Herbal Extracts, Reduces Osteoclast Differentiation In Vitro and Prevents Alveolar Bone Resorption in Rat Experimental Periodontitis J Clin Med 10:N/A (2021). PubMed: 33498415
- Chang Y et al. Ibudilast Mitigates Delayed Bone Healing Caused by Lipopolysaccharide by Altering Osteoblast and Osteoclast Activity. Int J Mol Sci 22:N/A (2021). PubMed: 33503906