Anti-Caspase-11 抗体 (ab22684)
Key features and details
- Rabbit polyclonal to Caspase-11
- Suitable for: WB
- Reacts with: Mouse
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-Caspase-11 antibody
Caspase-11 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Caspase-11 -
由来種
Rabbit -
特異性
ab22684 recognises caspase-11 proenzyme (43 kD) and the large (23 kD) and small (10 kD) subunits of the mature enzyme. No crossreactivity with other caspases tested: mouse caspases-1 and 3, human caspases 1 to 10 and 14. -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Mouse
非交差種: Human -
免疫原
Recombinant full length protein corresponding to Mouse Caspase-11.
Database link: P70343 -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. -
バッファー
Preservative: 0.05% Sodium azide -
Concentration information loading... -
精製度
Whole antiserum -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab22684の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB | (2) |
Use at an assay dependent concentration.
|
| 特記事項 |
|---|
|
WB
Use at an assay dependent concentration. |
ターゲット情報
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機能
Involved in ER-stress induced apoptosis. Cleaves caspase-1 (By similarity). Involved in the activation cascade of caspases responsible for apoptosis execution. Promotes IL-1 beta processing by ICE, so may also have a role in inflammatory responses. -
組織特異性
Mostly expressed in lung and spleen; weaker in heart and lung; little in liver, skeletal muscle, kidney and testis. Not found in the brain. -
配列類似性
Belongs to the peptidase C14A family.
Contains 1 CARD domain. -
翻訳後修飾
The two subunits are derived from the precursor sequence by a autocatalytic mechanism. -
細胞内局在
Endoplasmic reticulum membrane. Mitochondrion. - Information by UniProt
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参照データベース
- Entrez Gene: 12363 Mouse
- SwissProt: P70343 Mouse
- Unigene: 1569 Mouse
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別名
- CASP-11 antibody
- CASP-4 antibody
- CASP11 antibody
see all
データシートおよび資料
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Datasheet download
参考文献 (5)
ab22684 は 5 報の論文で使用されています。
- Wang J et al. CircHIPK3 Promotes Pyroptosis in Acinar Cells Through Regulation of the miR-193a-5p/GSDMD Axis. Front Med (Lausanne) 7:88 (2020). PubMed: 32318575
- Holani R et al. Cathelicidin-mediated lipopolysaccharide signaling via intracellular TLR4 in colonic epithelial cells evokes CXCL8 production. Gut Microbes 12:1785802 (2020). PubMed: 32658599
- Bi F et al. Rhein Protects Against Neurological Deficits After Traumatic Brain Injury in Mice via Inhibiting Neuronal Pyroptosis. Front Pharmacol 11:564367 (2020). PubMed: 33101024
- Xu J et al. Macrophage endocytosis of high-mobility group box 1 triggers pyroptosis. Cell Death Differ N/A:N/A (2014). PubMed: 24769733
- Kang MJ et al. IL-18 is induced and IL-18 receptor alpha plays a critical role in the pathogenesis of cigarette smoke-induced pulmonary emphysema and inflammation. J Immunol 178:1948-59 (2007). WB ; Mouse . PubMed: 17237446
