Anti-Cannabinoid Receptor I 抗体 (ab3558)
Key features and details
- Rabbit polyclonal to Cannabinoid Receptor I
- Suitable for: IP, ICC/IF, IHC-Fr, IHC-P, Flow Cyt, WB
- Reacts with: Mouse, Rat, Rabbit, Human, Ferret
- Isotype: IgG
製品の概要
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製品名
Anti-Cannabinoid Receptor I antibody
Cannabinoid Receptor I 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Cannabinoid Receptor I -
由来種
Rabbit -
特異性
Detects CB1 from Human and Rat tissues as well as transfected Rat CB1. -
アプリケーション
適用あり: IP, ICC/IF, IHC-Fr, IHC-P, Flow Cyt, WBmore details -
種交差性
交差種: Mouse, Rat, Rabbit, Human, Ferret
交差が予測される動物種: Cat, Chimpanzee, Rhesus monkey -
免疫原
Recombinant fragment within Human Cannabinoid Receptor I aa 1-100 (N terminal). The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 0.1% BSA, 49% PBS -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab3558の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IP |
Use at an assay dependent concentration. PubMed: 22387618
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ICC/IF |
1/1000.
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IHC-Fr |
Use at an assay dependent concentration.
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IHC-P |
Use at an assay dependent concentration.
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Flow Cyt |
Use at an assay dependent concentration. PubMed: 20206138
ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody. |
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WB |
Use at an assay dependent concentration. Predicted molecular weight: 53 kDa.
By Western blot, this antibody detects an ~60 kDa protein representing CB1 from rat brain homogenate. |
特記事項 |
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IP
Use at an assay dependent concentration. PubMed: 22387618 |
ICC/IF
1/1000. |
IHC-Fr
Use at an assay dependent concentration. |
IHC-P
Use at an assay dependent concentration. |
Flow Cyt
Use at an assay dependent concentration. PubMed: 20206138 ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody. |
WB
Use at an assay dependent concentration. Predicted molecular weight: 53 kDa. By Western blot, this antibody detects an ~60 kDa protein representing CB1 from rat brain homogenate. |
ターゲット情報
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機能
Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding. -
組織特異性
Widely expressed. -
配列類似性
Belongs to the G-protein coupled receptor 1 family. -
細胞内局在
Cell membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 1268 Human
- Entrez Gene: 12801 Mouse
- Entrez Gene: 25248 Rat
- Omim: 114610 Human
- SwissProt: O02777 Cat
- SwissProt: Q5IS73 Chimpanzee
- SwissProt: P21554 Human
- SwissProt: P47746 Mouse
see all -
別名
- CANN6 antibody
- Cannabinoid receptor 1 antibody
- CB-R antibody
see all
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (5)
ab3558 は 5 報の論文で使用されています。
- Liu AN et al. The Effects of HP0044 and HP1275 Knockout Mutations on the Structure and Function of Lipopolysaccharide in Helicobacter pylori Strain 26695. Biomedicines 10:N/A (2022). PubMed: 35052824
- Wang Y et al. Low-Dose Delta-9-Tetrahydrocannabinol as Beneficial Treatment for Aged APP/PS1 Mice. Int J Mol Sci 23:N/A (2022). PubMed: 35269905
- Kleyer J et al. Cannabinoid receptor trafficking in peripheral cells is dynamically regulated by a binary biochemical switch. Biochem Pharmacol 83:1393-412 (2012). Flow Cyt, IP ; Human . PubMed: 22387618
- Shen L et al. The role of peripheral cannabinoid receptors type 1 in rats with visceral hypersensitivity induced by chronic restraint stress. J Neurogastroenterol Motil 16:281-90 (2010). WB ; Rat . PubMed: 20680167
- Leonti M et al. Falcarinol is a covalent cannabinoid CB1 receptor antagonist and induces pro-allergic effects in skin. Biochem Pharmacol 79:1815-26 (2010). WB, Flow Cyt ; Human . PubMed: 20206138