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  1. Link

    cannabinoid-receptor-i-antibody-ab23703.pdf

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Neuroscience Neurotransmission Receptors / Channels GPCR Cannabinoid Receptor
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Anti-Cannabinoid Receptor I 抗体 (ab23703)

  • Datasheet
  • SDS
Reviews (20)Q&A (14)References (79)

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Abpromise

保証された製品品質、優れたカスタマー・サポート。 詳細はこちら。

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cannabinoid Receptor I antibody (ab23703)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cannabinoid Receptor I antibody (ab23703)

Key features and details

  • Rabbit polyclonal to Cannabinoid Receptor I
  • Suitable for: IHC-P, ICC/IF, IHC-Fr
  • Reacts with: Mouse, Rat, Dog, Human
  • Isotype: IgG

こちらの製品もご検討ください

Biochemical
Product image
AMG 9810, TRPV1 receptor antagonist (ab145874)
タンパク質
Product image
Recombinant Human Cannabinoid Receptor I protein (ab158150)
二次抗体
Product image
Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

関連製品

製品の概要

  • 製品名

    Anti-Cannabinoid Receptor I antibody
    Cannabinoid Receptor I 一次抗体 製品一覧
  • 製品の詳細

    Rabbit polyclonal to Cannabinoid Receptor I
  • 由来種

    Rabbit
  • アプリケーション

    適用あり: IHC-P, ICC/IF, IHC-Frmore details
  • 種交差性

    交差種: Mouse, Rat, Dog, Human
    交差が予測される動物種: Cow, Chimpanzee, Macaque monkey
  • 免疫原

    Synthetic peptide:

    MSVSTDTSAE AL

    , corresponding to C terminal amino acids 461-472 of Human Cannabinoid Receptor I(Peptide available as ab50542.)
    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • 特記事項

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

製品の特性

  • 製品の状態

    Liquid
  • 保存方法

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファー

    pH: 7.40
    Preservative: 0.02% Sodium azide
    Constituents: Tris buffered saline, 50% Glycerol, 0.05% BSA
  • Concentration information loading...
  • 精製度

    Protein A purified
  • ポリ/モノ

    ポリクローナル
  • アイソタイプ

    IgG
  • 研究分野

    • Neuroscience
    • Neurotransmission
    • Receptors / Channels
    • GPCR
    • Cannabinoid Receptor
    • Cardiovascular
    • Lipids / Lipoproteins
    • Lipid Metabolism
    • Cholesterol Metabolism
    • Signal Transduction
    • Metabolism
    • Drug metabolism
    • Cardiovascular
    • Atherosclerosis
    • Lipoprotein metabolism
    • Metabolism
    • Pathways and Processes
    • Metabolic signaling pathways
    • Lipid and lipoprotein metabolism
    • Cholesterol Metabolism
    • Metabolism
    • Pathways and Processes
    • Metabolic signaling pathways
    • Lipid and lipoprotein metabolism
    • Lipoprotein metabolism
    • Metabolism
    • Types of disease
    • Cancer
    • Metabolism
    • Types of disease
    • Heart disease
    • Neuroscience
    • Processes

関連製品

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Immunizing Peptide (Blocking)

    • Cannabinoid Receptor I peptide (ab50542)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
  • Recombinant Protein

    • Recombinant Human Cannabinoid Receptor I protein (ab158150)

アプリケーション

The Abpromise guarantee

Abpromise保証は、 次のテスト済みアプリケーションにおけるab23703の使用に適用されます

アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。

アプリケーション Abreviews 特記事項
IHC-P (7)
Use at an assay dependent concentration.
ICC/IF (4)
Use at an assay dependent concentration.
IHC-Fr (2)
Use at an assay dependent concentration.

Detection with an ABC system is recommended.

特記事項
IHC-P
Use at an assay dependent concentration.
ICC/IF
Use at an assay dependent concentration.
IHC-Fr
Use at an assay dependent concentration.

Detection with an ABC system is recommended.

ターゲット情報

  • 機能

    Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.
  • 組織特異性

    Widely expressed.
  • 配列類似性

    Belongs to the G-protein coupled receptor 1 family.
  • 細胞内局在

    Cell membrane.
  • Target information above from: UniProt accession P21554 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • 参照データベース

    • Entrez Gene: 100299449 Cow
    • Entrez Gene: 481913 Dog
    • Entrez Gene: 1268 Human
    • Entrez Gene: 12801 Mouse
    • Entrez Gene: 25248 Rat
    • Omim: 114610 Human
    • SwissProt: Q5IS73 Chimpanzee
    • SwissProt: P21554 Human
    • SwissProt: P47746 Mouse
    • SwissProt: P20272 Rat
    • Unigene: 709067 Human
    • Unigene: 75110 Human
    • Unigene: 7992 Mouse
    • Unigene: 222240 Rat
    • Unigene: 89774 Rat
    see all
  • 別名

    • CANN6 antibody
    • Cannabinoid receptor 1 antibody
    • CB-R antibody
    • CB1 antibody
    • CB1A antibody
    • CB1K5 antibody
    • CB1R antibody
    • Central cannabinoid receptor antibody
    • CNR antibody
    • CNR1 antibody
    • CNR1_HUMAN antibody
    • OTTHUMP00000016838 antibody
    • OTTHUMP00000214579 antibody
    see all

画像

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cannabinoid Receptor I antibody (ab23703)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cannabinoid Receptor I antibody (ab23703)
    Immunoperoxidase staining of CA region of rat hippocampus with the Cannabinoid Receptor I antibody (ab23703, 4ug/ml). the majority of the protein is localized in the pre-synaptic axons, shown as brown particulaes. A few neurons also show cytoplasm staining.
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cannabinoid Receptor I antibody (ab23703)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cannabinoid Receptor I antibody (ab23703)Courtesy of an annonymous Abreview

    ab23703 staining Cannabinoid Receptor I in human pancreas tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with paraformaldehyde and blocked with 5% serum for 1 hour at room temperature; antigen retrieval was by heat mediation in a citrate buffer. Samples were incubated with primary antibody (1/50 in PBS) for 8 hours at 4°C. A Biotin-conjugated Goat anti-rabbit IgG polyclonal (1/1000) was used as the secondary antibody.

    See Abreview

プロトコール

  • Immunohistochemistry protocols
  • Western blot protocols

Click here to view the general protocols

データシートおよび資料

  • Datasheet download

    Download

参考文献 (79)

ab23703 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

ab23703 は 79 報の論文で使用されています。

  • He XL  et al. Solid lipid nanoparticles loading with curcumin and dexanabinol to treat major depressive disorder. Neural Regen Res 16:537-542 (2021). PubMed: 32985484
  • Lah TT  et al. Cannabigerol Is a Potential Therapeutic Agent in a Novel Combined Therapy for Glioblastoma. Cells 10:N/A (2021). PubMed: 33562819
  • Daddam JR  et al. Phosphoproteomic Analysis of Subcutaneous and Omental Adipose Tissue Reveals Increased Lipid Turnover in Dairy Cows Supplemented with Conjugated Linoleic Acid. Int J Mol Sci 22:N/A (2021). PubMed: 33810070
  • Rodriguez JL  et al. Involvement of the endocannabinoid system in the inhibition of Sindbis virus replication: a preliminary study. J Cannabis Res 3:10 (2021). PubMed: 33892823
  • Lee DI  et al. Cannabinoid Receptor Agonist Inhibits Atrial Electrical Remodeling in a Tachypaced Ex Vivo Rat Model. Front Pharmacol 12:642398 (2021). PubMed: 33967775
View all Publications for this product

レビューと Q&A

Show All レビュー Q&A
レビューを送る 質問を送る

1-10 of 34 Abreviews or Q&A

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) abreview for Anti-Cannabinoid Receptor I antibody

Excellent
Abreviews
Abreviews
abreview image
Application
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Sample
Rhesus monkey Tissue sections (pituitary gland)
Antigen retrieval step
Heat mediated - Buffer/Enzyme Used: Citrus pH 6.0
Permeabilization
No
Specification
pituitary gland
Blocking step
Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 2% · Temperature: 23°C
Fixative
Paraformaldehyde
Read More

Abcam user community

Verified customer

投稿 Jan 28 2020

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) abreview for Anti-Cannabinoid Receptor I antibody

Excellent
Abreviews
Abreviews
abreview image
Application
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Sample
Horse Tissue sections (Brain)
Antigen retrieval step
Enzymatic - Buffer/Enzyme Used: Hyaluronidase
Permeabilization
Yes - BSA
Specification
Brain
Blocking step
Serum as blocking agent for 30 minute(s) · Concentration: 20%
Fixative
Formaldehyde
Read More

Abcam user community

Verified customer

投稿 Nov 18 2019

Immunohistochemistry (Frozen sections) abreview for Anti-Cannabinoid Receptor I antibody

Excellent
Abreviews
Abreviews
abreview image
Application
Immunohistochemistry (Frozen sections)
Sample
Horse Tissue sections (dorsal root ganglion)
Permeabilization
Yes - Triton
Specification
dorsal root ganglion
Blocking step
BSA as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 20% · Temperature: 20°C
Fixative
Paraformaldehyde
Read More

Abcam user community

Verified customer

投稿 May 23 2019

Immunohistochemistry (Frozen sections) abreview for Anti-Cannabinoid Receptor I antibody

Excellent
Abreviews
Abreviews
abreview image
Application
Immunohistochemistry (Frozen sections)
Sample
Cat Tissue sections (gastrointestinal tract)
Permeabilization
Yes - Triton
Specification
gastrointestinal tract
Blocking step
Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 20% · Temperature: 20°C
Fixative
Paraformaldehyde
Read More

Roberto Chiocchetti

Verified customer

投稿 Dec 04 2018

Western blot abreview for Anti-Cannabinoid Receptor I antibody

Excellent
Abreviews
Abreviews
abreview image
Application
Western blot
Sample
Chicken Cell lysate - whole cell (Cerebellar granule neurons from embryonic day 17 c)
Gel Running Conditions
Non-reduced Denaturing (4-10 %)
Loading amount
25 µg
Treatment
Various chemicals, including Paracetamol, AM-404, Rimonabant
Specification
Cerebellar granule neurons from embryonic day 17 c
Blocking step
Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 25°C
Read More

DR. Mussie Ghezu Hadera

Verified customer

投稿 Sep 18 2018

Flow Cytometry abreview for Anti-Cannabinoid Receptor I antibody

Average
Abreviews
Abreviews
abreview image
Application
Flow Cytometry
Sample
Mouse Cell (Spleen cells)
Permeabilization
No
Gating Strategy
live cells
Specification
Spleen cells
Preparation
Cell harvesting/tissue preparation method: cell culture (RPMI)
Sample buffer: PBS 1x
Fixation
Fresh cells
Read More

Ms. Coral González García

Verified customer

投稿 Aug 21 2015

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) abreview for Anti-Cannabinoid Receptor I antibody

Good
Abreviews
Abreviews
abreview image
Application
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Blocking step
Serum as blocking agent for 45 minute(s) · Concentration: 2.5% · Temperature: RT°C
Antigen retrieval step
Heat mediated - Buffer/Enzyme Used: Citrate buffer pH6
Sample
Cat Tissue sections (Felis catus brain parietal cortex)
Specification
Felis catus brain parietal cortex
Permeabilization
No
Fixative
Formaldehyde
Read More

Abcam user community

Verified customer

投稿 Nov 05 2014

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) abreview for Anti-Cannabinoid Receptor I antibody

Good
Abreviews
Abreviews
Application
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Blocking step
Dako Flex peroxidase as blocking agent for 5 minute(s) · Concentration: 100% · Temperature: RT°C
Antigen retrieval step
Heat mediated - Buffer/Enzyme Used: High pH
Sample
Human Tissue sections (Tendon)
Specification
Tendon
Permeabilization
No
Fixative
10% buffered formalin
Read More

Abcam user community

Verified customer

投稿 Oct 22 2014

Western blot abreview for Anti-Cannabinoid Receptor I antibody

Excellent
Abreviews
Abreviews
abreview image
Application
Western blot
Loading amount
50 µg
Gel Running Conditions
Non-reduced Non-Denaturing (Native) (10% gel)
Sample
Rat Tissue lysate - whole (bladder)
Specification
bladder
Blocking step
Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 10% · Temperature: 25°C
Read More

DR. Eun-Young Park

Verified customer

投稿 Jul 18 2013

Western blot abreview for Anti-Cannabinoid Receptor I antibody

Average
Abreviews
Abreviews
abreview image
Application
Western blot
Sample
Mouse Tissue lysate - other (mouse brain - post nuclear supernatant)
Loading amount
20 µg
Specification
mouse brain - post nuclear supernatant
Gel Running Conditions
Reduced Denaturing (12%)
Blocking step
Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 23°C
Read More

Abcam user community

Verified customer

投稿 Feb 05 2013

1-10 of 34 Abreviews or Q&A

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