Anti-cAMP 抗体 [EP8471] (ab134901)
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EP8471] to cAMP
- Suitable for: ELISA, ICC/IF
- Reacts with: Species independent
Related conjugates and formulations
製品の概要
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製品名
Anti-cAMP antibody [EP8471]
cAMP 一次抗体 製品一覧 -
製品の詳細
Rabbit monoclonal [EP8471] to cAMP -
由来種
Rabbit -
特異性
This antibody does not cross react with cGMP, GMP, GDP, cIMP, cCMP, or adenosine. -
アプリケーション
適用あり: ELISA, ICC/IFmore details -
種交差性
交差種: Species independent -
免疫原
Chemical/ Small Molecule corresponding to cAMP conjugated to keyhole limpet haemocyanin.
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特記事項
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
バッファー
pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA -
Concentration information loading...
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精製度
Protein A purified -
ポリ/モノ
モノクローナル -
クローン名
EP8471 -
アイソタイプ
IgG -
研究分野
関連製品
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Alternative Versions
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab134901の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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ELISA |
Use a concentration of 0.25 µg/ml.
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ICC/IF |
Use a concentration of 5 µg/ml.
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特記事項 |
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ELISA
Use a concentration of 0.25 µg/ml. |
ICC/IF
Use a concentration of 5 µg/ml. |
ターゲット情報
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関連性
Cyclic adenosine monophosphate (cAMP) plays a key role as an intracellular second messenger for transduction events that follow a number of extracellular signals. The G-Protein Coupled Receptors (GPCR) is the largest family of cell surface receptors. They can be activated by different ligands, such as neurotransmitters, hormones, ions, small molecules, peptides, and other physiological signaling molecules. Typically, the binding of the ligands to its receptor resulting in the activation of G-proteins, in return, activates the effector adenylyl cyclase evoking the production of cAMP. The activation of a protein kinase by cAMP results in the phosphorylation of substrate proteins. Currently successful drugs in marketing have been developed to target these receptors. Among the GPCRs, ~367 receptors are potential drug development targets, but only about 20 have been used to generate therapeutically and commercially successful drugs so far. Because the involvement of cAMP can amplify the response of the ligand binding, the second messenger cAMP has been largely employed to monitor the activation of the GPCR to facilitate the therapeutic drug discovery. -
細胞内局在
Secreted -
別名
- 3' 5' cyclic adenosine monophosphate antibody
- Cyclic adenosine monophosphate antibody
- Cyclic AMP antibody
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (2)
ab134901 は 2 報の論文で使用されています。
- Cheng J et al. Microglial autophagy defect causes parkinson disease-like symptoms by accelerating inflammasome activation in mice. Autophagy 16:2193-2205 (2020). PubMed: 32003282
- Jiang X et al. Pinoresinol promotes MC3T3-E1 cell proliferation and differentiation via the cyclic AMP/protein kinase A signaling pathway. Mol Med Rep 20:2143-2150 (2019). PubMed: 31322181