Anti-Calponin 1 抗体 [CALP] (ab700)
Key features and details
- Mouse monoclonal [CALP] to Calponin 1
- Suitable for: Flow Cyt, ICC/IF, IHC-FoFr, IHC-P, IHC-Fr
- Reacts with: Rat, Human
- Isotype: IgG1
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-Calponin 1 antibody [CALP]
Calponin 1 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [CALP] to Calponin 1 -
由来種
Mouse -
アプリケーション
適用あり: Flow Cyt, ICC/IF, IHC-FoFr, IHC-P, IHC-Frmore details -
種交差性
交差種: Rat, Human -
免疫原
The details of the immunogen for this antibody are not available.
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ポジティブ･コントロール
- Myoepithelium in normal breast glands.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
Constituents: PBS, Tissue culture supernatant
Proprietary preservative that is not sodium azide or thimerosal, protein carrier. -
Concentration information loading... -
ポリ/モノ
モノクローナル -
クローン名
CALP -
ミエローマ
unknown -
アイソタイプ
IgG1 -
軽鎖の種類
kappa -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab700の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| Flow Cyt |
Use at an assay dependent concentration. PubMed: 20618694
ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
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| ICC/IF | (2) |
Use at an assay dependent concentration.
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| IHC-FoFr |
Use at an assay dependent concentration. PubMed: 20138661
|
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| IHC-P | (1) |
Use at an assay dependent concentration.
ABC system. 30mins at RT. |
| IHC-Fr |
Use at an assay dependent concentration.
ABC system. 30mins at RT.Calponin 1 has been found to be useful as a marker for myoepithelial and basal lamina in differentiating microinvasive from in situ ductal carcinomas of the breast. Calponin 1 has also been useful in malignant myoepithelium and pleomorphoric adenoma of salivary gland as well as a useful marker for fine needle aspirates of papillary breast lesions. |
| 特記事項 |
|---|
|
Flow Cyt
Use at an assay dependent concentration. PubMed: 20618694 ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
|
ICC/IF
Use at an assay dependent concentration. |
|
IHC-FoFr
Use at an assay dependent concentration. PubMed: 20138661 |
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IHC-P
Use at an assay dependent concentration. ABC system. 30mins at RT. |
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IHC-Fr
Use at an assay dependent concentration. ABC system. 30mins at RT.Calponin 1 has been found to be useful as a marker for myoepithelial and basal lamina in differentiating microinvasive from in situ ductal carcinomas of the breast. Calponin 1 has also been useful in malignant myoepithelium and pleomorphoric adenoma of salivary gland as well as a useful marker for fine needle aspirates of papillary breast lesions. |
ターゲット情報
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機能
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. -
組織特異性
Smooth muscle, and tissues containing significant amounts of smooth muscle. -
配列類似性
Belongs to the calponin family.
Contains 3 calponin-like repeats.
Contains 1 CH (calponin-homology) domain. - Information by UniProt
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参照データベース
- Entrez Gene: 1264 Human
- Entrez Gene: 65204 Rat
- Omim: 600806 Human
- SwissProt: P51911 Human
- SwissProt: Q08290 Rat
- Unigene: 465929 Human
- Unigene: 31788 Rat
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別名
- Basic calponin antibody
- Calponin 1 antibody
- Calponin 1 basic smooth muscle antibody
see all
データシートおよび資料
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Datasheet download
参考文献 (23)
ab700 は 23 報の論文で使用されています。
- Zhang J et al. Polycystin-1 Downregulation Induced Vascular Smooth Muscle Cells Phenotypic Alteration and Extracellular Matrix Remodeling in Thoracic Aortic Dissection. Front Physiol 11:548055 (2020). PubMed: 33071810
- Fang L et al. Nucleolin promotes Ang II-induced phenotypic transformation of vascular smooth muscle cells via interaction with tropoelastin mRNA. Int J Mol Med 43:1597-1610 (2019). PubMed: 30720050
- Kasprzyk-Pawelec A et al. microRNA expression profile in Smooth Muscle Cells isolated from thoracic aortic aneurysm samples. Adv Med Sci 64:331-337 (2019). PubMed: 31022558
- Maclellan RA et al. Analysis of Follicle-Stimulating Hormone Receptor in Infantile Hemangioma. Ann Plast Surg 80:S211-S213 (2018). PubMed: 29596087
- Tamosiuniene R et al. Dominant Role for Regulatory T Cells in Protecting Females Against Pulmonary Hypertension. Circ Res 122:1689-1702 (2018). PubMed: 29545367
