Anti-Calcium-independent Phospholipase A2/PLA2G6 抗体 (ab104416)
Key features and details
- Rabbit polyclonal to Calcium-independent Phospholipase A2/PLA2G6
- Suitable for: WB
- Reacts with: Mouse, Human
- Isotype: IgG
製品の概要
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製品名
Anti-Calcium-independent Phospholipase A2/PLA2G6 antibody
Calcium-independent Phospholipase A2/PLA2G6 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Calcium-independent Phospholipase A2/PLA2G6 -
由来種
Rabbit -
特異性
Reactive against mammalian transfected lysate. -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Mouse, Human -
免疫原
Recombinant full length protein within Human Calcium-independent Phospholipase A2/PLA2G6. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
Database link: NP_001004426.1 -
ポジティブ・コントロール
- Human kidney tissue lysate, Mouse kidney tissue lysate, Transfected 293T cell lysate
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.40
Constituent: 100% PBS -
Concentration information loading...
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精製度
Protein A purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab104416の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
Use a concentration of 1 µg/ml. Predicted molecular weight: 90 kDa.
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特記事項 |
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WB
Use a concentration of 1 µg/ml. Predicted molecular weight: 90 kDa. |
ターゲット情報
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機能
Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F-actin polymerization at the pseudopods.
Isoform ankyrin-iPLA2-1 and isoform ankyrin-iPLA2-2, which lack the catalytic domain, are probably involved in the negative regulation of iPLA2 activity. -
組織特異性
Four different transcripts were found to be expressed in a distinct tissue distribution. -
関連疾患
Neurodegeneration with brain iron accumulation 2B
Neurodegeneration with brain iron accumulation 2A
Parkinson disease 14 -
配列類似性
Contains 7 ANK repeats.
Contains 1 patatin domain. -
細胞内局在
Cytoplasm and Membrane. Recruited to the membrane-enriched pseudopod upon MCP1/CCL2 stimulation in monocytes. - Information by UniProt
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参照データベース
- Entrez Gene: 8398 Human
- Entrez Gene: 53357 Mouse
- Omim: 603604 Human
- SwissProt: O60733 Human
- SwissProt: P97819 Mouse
- Unigene: 170479 Human
- Unigene: 155620 Mouse
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製品の状態
The isoform LH-iPLA2 is located at the membrane. The isoform SH-iPLA2 is cytoplasmic. -
別名
- 85 kDa calcium independent phospholipase A2 antibody
- 85/88 kDa calcium-independent phospholipase A2 antibody
- BB112799 antibody
see all
画像
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Anti-Calcium-independent Phospholipase A2/PLA2G6 antibody (ab104416) at 1 µg/ml + Human kidney tissue lysate at 50 µg
Predicted band size: 90 kDa -
Anti-Calcium-independent Phospholipase A2/PLA2G6 antibody (ab104416) at 1 µg/ml + Mouse kidney tissue lysate at 50 µg
Predicted band size: 90 kDa -
All lanes : Anti-Calcium-independent Phospholipase A2/PLA2G6 antibody (ab104416) at 1 µg/ml
Lane 1 : Calcium-independent Phospholipase A2/PLA2G6 transfected 293T lysate
Lane 2 : Non-transfected 293T lysate
Lysates/proteins at 25 µg per lane.
Predicted band size: 90 kDa
Observed band size: 84 kDa why is the actual band size different from the predicted?
データシートおよび資料
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Datasheet download
参考文献 (0)
ab104416 は論文での使用が確認できていません。