Anti-C5a / C5a des Arg 抗体 [2952] (ab11878)
Key features and details
- Mouse monoclonal [2952] to C5a / C5a des Arg
- Suitable for: ELISA, IHC-Fr, Functional Studies, WB, IHC-P
- Reacts with: Human
- Isotype: IgG1
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-C5a / C5a des Arg antibody [2952]
C5a / C5a des Arg 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [2952] to C5a / C5a des Arg -
由来種
Mouse -
特異性
This antibody reacts with a neo-epitope (des-Arg) on C5a that is formed upon cleavage of C5 into C5a and C5b. It will detect C5a and C5a des-Arg (Not C5).
Please notice that under given conditions it is known that C5 can expose epitopes normally only found in the cleaved activation products.
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アプリケーション
適用あり: ELISA, IHC-Fr, Functional Studies, WB, IHC-Pmore details -
種交差性
交差種: Human -
免疫原
Other Immunogen Type. This information is proprietary to Abcam and/or its suppliers.
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ポジティブ･コントロール
- Human Granulocytes
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
Constituents: PBS, 0.1% BSA -
Concentration information loading... -
精製度
Protein G purified -
特記事項（精製）
0.2 µm filtered -
ポリ/モノ
モノクローナル -
クローン名
2952 -
アイソタイプ
IgG1 -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab11878の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| ELISA | (1) |
Use at an assay dependent concentration.
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| IHC-Fr |
Use at an assay dependent concentration.
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| Functional Studies |
Use at an assay dependent concentration.
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| WB |
Use at an assay dependent concentration.
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| IHC-P |
Use at an assay dependent concentration.
|
| 特記事項 |
|---|
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ELISA
Use at an assay dependent concentration. |
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IHC-Fr
Use at an assay dependent concentration. |
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Functional Studies
Use at an assay dependent concentration. |
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WB
Use at an assay dependent concentration. |
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IHC-P
Use at an assay dependent concentration. |
ターゲット情報
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関連性
C5 is involved in the activation of the lytic pathway within the complement system, which is an important factor in innate immunity. -
参照データベース
- Entrez Gene: 727 Human
- Omim: 120900 Human
- SwissProt: P01031 Human
- SwissProt: Q14CJ0 Human
- SwissProt: Q27I61 Human
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別名
- Anaphylatoxin C5a analog antibody
- C5 antibody
- C5a anaphylatoxin antibody
see all
プロトコール
データシートおよび資料
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Datasheet download
参考文献 (5)
ab11878 は 5 報の論文で使用されています。
- Yuan K et al. Complement C3 overexpression activates JAK2/STAT3 pathway and correlates with gastric cancer progression. J Exp Clin Cancer Res 39:9 (2020). PubMed: 31928530
- Arbore G et al. Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism. Nat Commun 9:4186 (2018). PubMed: 30305631
- Xi W et al. High Level of Anaphylatoxin C5a Predicts Poor Clinical Outcome in Patients with Clear Cell Renal Cell Carcinoma. Sci Rep 6:29177 (2016). IHC ; Human . PubMed: 27381421
- Ecker SM et al. Aqueous cytokine and growth factor levels do not reliably reflect those levels found in the vitreous. Mol Vis 17:2856-63 (2011). WB ; Human . PubMed: 22128233
- Nozaki M et al. Drusen complement components C3a and C5a promote choroidal neovascularization. Proc Natl Acad Sci U S A 103:2328-33 (2006). IHC-Fr ; Mouse, Human . PubMed: 16452172
