Anti-C1q 抗体 [JL-1] (ab71940)
Key features and details
- Mouse monoclonal [JL-1] to C1q
- Suitable for: Dot blot, ELISA
- Reacts with: Mouse, Human
- Isotype: IgG2b
製品の概要
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製品名
Anti-C1q antibody [JL-1]
C1q 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [JL-1] to C1q -
由来種
Mouse -
アプリケーション
適用あり: Dot blot, ELISAmore details -
種交差性
交差種: Mouse, Human -
免疫原
Purified mouse C1q
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エピトープ
The monoclonal antibody JL-1is reactive with the collagen-like region (CLR). -
特記事項
The antibody has been generated by immunization of C1q-/- C57BL/6 mice with purified mouse C1q.The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
Constituents: 0.1% BSA, PBS -
Concentration information loading...
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精製度
Protein G purified -
特記事項(精製)
0.2µm filtered. -
ポリ/モノ
モノクローナル -
クローン名
JL-1 -
アイソタイプ
IgG2b -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab71940の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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Dot blot |
Use at an assay dependent concentration.
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ELISA | (1) |
Use at an assay dependent concentration.
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特記事項 |
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Dot blot
Use at an assay dependent concentration. |
ELISA
Use at an assay dependent concentration. |
ターゲット情報
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機能
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. -
関連疾患
Defects in C1QA are a cause of complement component C1q deficiency (C1QD) [MIM:613652]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis. -
配列類似性
Contains 1 C1q domain.
Contains 1 collagen-like domain. -
翻訳後修飾
O-linked glycans consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups. -
細胞内局在
Secreted. - Information by UniProt
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参照データベース
- Entrez Gene: 712 Human
- Entrez Gene: 713 Human
- Entrez Gene: 714 Human
- Entrez Gene: 12259 Mouse
- Entrez Gene: 12260 Mouse
- Entrez Gene: 12262 Mouse
- Omim: 120550 Human
- Omim: 120570 Human
see all -
別名
- C1qa antibody
- C1QA_HUMAN antibody
- C1QB antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (33)
ab71940 は 33 報の論文で使用されています。
- Bao L et al. Engineered neutrophil apoptotic bodies ameliorate myocardial infarction by promoting macrophage efferocytosis and inflammation resolution. Bioact Mater 9:183-197 (2022). PubMed: 34820565
- Miller-Rhodes P et al. URMC-099 prophylaxis prevents hippocampal vascular vulnerability and synaptic damage in an orthopedic model of delirium superimposed on dementia. FASEB J 36:e22343 (2022). PubMed: 35535564
- De Gaetano GV et al. Streptococcus pneumoniae binds collagens and C1q via the SSURE repeats of the PfbB adhesin. Mol Microbiol 117:1479-1492 (2022). PubMed: 35570359
- Micheli L et al. Efficacy of a vegetal mixture composed of Zingiber officinale, Echinacea purpurea, and Centella asiatica in a mouse model of neuroinflammation: In vivo and ex vivo analysis. Front Nutr 9:887378 (2022). PubMed: 36118773
- Zheng Y et al. Role of complement C1q/C3-CR3 signaling in brain injury after experimental intracerebral hemorrhage and the effect of minocycline treatment. Front Immunol 13:919444 (2022). PubMed: 36189326