BMS-833923, smoothened antagonist (ab269875)
Key features and details
- Potent Smoothened antagonist
- CAS Number: 1059734-66-5
Soluble in water to 5 mM, in DMSO to 100 mM and in ethanol to 10 mM (with warming and ultrasonic)
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
BMS-833923, smoothened antagonist -
製品の詳細
Potent Smoothened antagonist -
生理活性の詳細
Potent Smoothened antagonist (IC50 = 5.8 nM). Blocks Hedgehog signaling in cell-based assays. Inhibits Gli1 and PTCH1 expression in cell lines. Reduces proliferation and induces apoptosis in tumor cellls.
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CAS 番号
1059734-66-5 -
構造式
製品の特性
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体系名
N-[2-Methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenyl-2- quinazolinyl)amino]benzamide
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分子量
473.57 -
分子式
C30H27N5O -
PubChem 登録番号
57662985 -
保存方法
Shipped at room temperature. Store at -20°C. -
溶解性
Soluble in water to 5 mM, in DMSO to 100 mM and in ethanol to 10 mM (with warming and ultrasonic)
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使用に関する注意
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CC1=C(C=C(C=C1)CNC)NC(=O)C2=CC=C(C=C2)NC3=NC4=CC=CC=C4C(=N3)C5=CC=CC=C5 -
由来
Synthetic
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (0)
ab269875 は論文での使用が確認できていません。