BMS 345541, IKK-2 and IKK-1 inhibitor (ab144822)
Key features and details
- Highly selective cell permeable IKK-2 and IKK-1 inhibitor
- CAS Number: 445430-58-0
- Purity: > 98%
Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
BMS 345541, IKK-2 and IKK-1 inhibitor -
製品の詳細
Highly selective cell permeable IKK-2 and IKK-1 inhibitor -
生理活性の詳細
Highly selective cell permeable IKK-2 and IKK-1 inhibitor (IC50 values are 0.3 and 4 μM for IKK-2 and IKK-1 respectively). Blocks NF-κB-dependent transcription. Shows anti-inflammatory and radiosensitizing effects in vivo. Orally active. -
精製度
> 98% -
CAS 番号
445430-58-0 -
構造式
製品の特性
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体系名
N'-(1,8-Dimethylimidazo[1,2-a]quinoxalin-4-yl)ethane-1,2-diamine
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分子量
255.32 -
分子式
C14H17N5 -
PubChem 登録番号
9813758 -
保存方法
Store at +4°C (desiccating conditions). -
溶解性
Soluble in DMSO to 25 mM
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使用に関する注意
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CC1=CC2=C(C=C1)N=C(C3=NC=C(N23)C)NCCN -
由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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Datasheet download
参考文献 (4)
ab144822 は 4 報の論文で使用されています。
- Cuaycal AE et al. Lactobacillus johnsonii N6.2 phospholipids induce immature-like dendritic cells with a migratory-regulatory-like transcriptional signature. Gut Microbes 15:2252447 (2023). PubMed: 37675983
- Mirzaei R et al. PD-1 independent of PD-L1 ligation promotes glioblastoma growth through the NF?B pathway. Sci Adv 7:eabh2148 (2021). PubMed: 34739319
- Hahn A et al. Serum amyloid A1 mediates myotube atrophy via Toll-like receptors. J Cachexia Sarcopenia Muscle 11:103-119 (2020). PubMed: 31441598
- Zhang Y et al. The Unknown Aspect of BAFF: Inducing IL-35 Production by a CD5+CD1dhiFc?RIIbhiRegulatory B-Cell Subset in Lupus. J Invest Dermatol 137:2532-2543 (2017). PubMed: 28844943