Welcome to the Abcam blog

Cytokeratin ~ 注目ターゲットのおすすめ製品


ウサギ・モノクローナル 抗体

ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

Cytokeratin 1Hu, MS, Rat WB, IHC-P, IHC-Fr ab185628
Cytokeratin 4HuFlow Cyt, ICC, ICC/IF, IHC-P, IP, WB6 ab51599
Cytokeratin 5Hu, MsIHC-Fr, ICC/IF, Flow Cyt, IHC-P, WB8 ab214586
Cytokeratin 6 HuICC, IHC-P, WB1 ab52620
Cytokeratin 7 Hu, Ms, RatICC/IF, IHC-Fr, IHC-P, WB39ab181598
Cytokeratin 7
BSA and Azide free
Hu, Ms, Rat ICC/IF, WB, IHC-Fr, IHC-P2 ab220804
Cytokeratin 8
BSA and Azide free
Hu, MsWB, IP, IHC-P, Flow Cyt, ICC/IF14 ab217173
Cytokeratin 8+18 Ms, HuFlow Cyt, ICC/IF, IHC-P, IP, WB173 ab53280
Cytokeratin 8 (pS73)Hu, Ms, RatICC/IF, IHC-Fr, IHC-P, WB56 ab32579
Cytokeratin 10Hu, Ms, RatICC/IF, IHC-Fr, IHC-P, WB87 ab76318
Cytokeratin 10
BSA and Azide free
Hu, Ms, Rat ICC/IF, IHC-Fr, WB, IHC-P8ab220806
Cytokeratin 13 Ms, HuICC, IHC-Fr, IHC-P, WB71 ab92551
Cytokeratin 14 Hu, Ms, RatICC/IF, IHC-P, WB23 ab181595
Cytokeratin 14
Alexa Fluor® 488
HuFlow Cyt, ICC/IF2 ab192055
Cytokeratin 15Hu, MsFlow Cyt, ICC/IF, IHC-P, WB81 ab52816
Cytokeratin 16 HuFlow Cyt, ICC, IHC-P, WB91 ab76416
Cytokeratin 17Hu, Ms, RatFlow Cyt, ICC/IF, IHC-P, WB3 ab109725
Cytokeratin 18 HuFlow Cyt, ICC/IF, IHC-Fr, IHC-P, WB145 ab32118
Cytokeratin 19 Hu, MsFlow Cyt, ICC/IF, IHC-P, WB237 ab52625
Cytokeratin 19
BSA and Azide free
Hu, Ms ICC/IF, Flow Cyt, IHC-P, WB8ab195872
Cytokeratin 20Goat, Hu, Mmst, Pig, RatFlow Cyt, ICC, IHC-Fr, IHC-P, IP, WB913 ab76126
Cytokeratin 20
BSA and Azide free
Goat, Hu, Mmst, Pig, Rat Flow Cyt, ICC/IF, IP, IHC-Fr, WB, IHC-P7ab219589

抗体

ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

Acidic CytokeratinMs-M Hu, Ms, Cow, Dog, Rb, Rat, Chk, Turt, MkFlow Cyt, ICC/IF, IHC-Fr, IHC-P, WB ab187381
Cytokeratin 1Ms-MMs, Rat, Chk, Cow, Mk, Rb, TurtIHC-Fr, IHC-P, WB92 ab9286
Cytokeratin 2Ms-M Ms, Rat, Rb, Chk, Cow, Hu, Mk, PigEM, IHC-Fr, IHC-P, WB ab16111
Cytokeratin 3Ms-MHu, Cow, RbFlow Cyt, ICC/IF, IHC-P, WB51 ab77869
Cytokeratin 3+12Ms-MHu, Ms, Cow, RbICC/IF, IHC-Fr, IHC-P, WB31 ab68260
Cytokeratin 4Ms-MHu, Cat, Dog, ZfshFlow Cyt, ICC, WB6 ab9004
Cytokeratin 5Rb-PHu, Ms, Rat, PigELISA, Flow Cyt, ICC/IF, IHC-FoFr, IHC-Fr, IHC-P, WB174 ab53121
Cytokeratin 5 + 6Ms-MHuIHC-P41 ab17133
Cytokeratin 5 + 8Ms-MHu, Ms, Rat, Dog, Hm, Pig, RbDot, Flow Cyt, ICC/IF, IHC-Fr, IHC-P, WB5 ab9005
Cytokeratin 6Ms-MHu, MsFlow Cyt, ICC, IHC-Fr, IHC-P, WB3 ab18586
Cytokeratin 7Ms-MHu, Ms, Rat, Cat, Dog, Goat, Hm, Pig, ZfshFlow Cyt, ICC, ICC/IF, IHC-Fr, IHC-P, WB2312 ab9021
Cytokeratin 8Ms-MHu, Rat, RbFlow Cyt, ICC, ICC/IF, IHC-Fr, IHC-P, WB139 ab9023
Cytokeratin 8+18Ms-MHuFlow Cyt, ICC/IF, IHC-P, WB11 ab17139
Cytokeratin 10Ms-MHu, Ms, Cat, Dog, ShpFlow Cyt, ICC, IHC-Fr, IHC-P, WB133 ab9026
Cytokeratin 10 + 13Ms-M Cat, Hu, Zfsh, DogFlow Cyt, ICC, IHC-Fr, IHC-P, WB12 ab9383
Cytokeratin 13Ms-MHu, Ms, RbICC/IF, IHC-P, WB102 ab16112
Cytokeratin 15Ms-MHu, Ms, Rat, CowFlow Cyt, ICC/IF, IHC-P22 ab80522
Cytokeratin 17Rb-PHu, Ms, RatELISA, ICC, ICC/IF, IHC-P, WB81 ab53707
Cytokeratin 18Ms-M Ms, Rat, Shp, Goat, Hrs, Hm, Cow, Dog, Hu, Pig, Mmst, CatFlow Cyt, ICC, ICC/IF, IHC-Fr, IHC-P, IP, WB4219 ab668
Cytokeratin 19Ms-MHuELISA, Flow Cyt, ICC, ICC/IF, IHC-Fr, IHC-P, IP, WB167 ab7754

タンパク質・ペプチド

製品名

由来

適用・アプリケーション

製品番号

Cytokeratin 1 protein HuELISA, SDS-PAGE, WBab114282
Cytokeratin 7 proteinHuELISA, SDS-PAGE, WBab132933
Cytokeratin 8 proteinHuSDS-PAGEab156970
Cytokeratin 10 protein HuELISA, SDS-PAGE, WBab114223
Cytokeratin 13 proteinHuELISA, SDS-PAGE, WBab112315
Cytokeratin 16 protein HuELISA, SDS-PAGE, WBab114405
Cytokeratin 17 proteinHuELISA, SDS-PAGE, WBab116974
Cytokeratin 18 proteinHuSDS-PAGE, WBab73638
タンパク質・ペプチド一覧

キット

製品名

交差種

容量

製品番号

Cytokeratin 14 Matched 抗体 Pair KitHu2 x 96 tests
10 x 96 tests
ab221423
キット一覧

ライゼート

製品名

適用・アプリケーション

製品番号

Cytokeratin 4 293T Transfected Lysate - (positive control)WBab94137
Cytokeratin 17 293T Transfected Lysate - (positive control)WBab94233
Cytokeratin 19 293T Transfected Lysate - (positive control)WBab94060

Cytokeratin について

Cytokeratin1
Function
機能
May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein kinase C (RACK1/GNB2L1).
Tissue specificity
組織特異性
The source of this protein is neonatal foreskin. The 67-kDa type II keratins are expressed in terminally differentiating epidermis.
Involvement in disease
関連疾患
  • bullous congenital ichthyosiform erythroderma
  • ichthyosis hystrix Curth-Macklin type
  • palmoplantar keratoderma non-epidermolytic
  • ichthyosis annular epidermolytic
  • palmoplantar keratoderma striate type 3
Cellular localization
細胞内局在性
Cell membrane. Located on plasma membrane of neuroblastoma NMB7 cells.

Cytokeratin2
Function
機能
Probably contributes to terminal cornification.

Cytokeratin3
Tissue specificity
組織特異性
Cornea specific.
Involvement in disease
関連疾患
Meesmann corneal dystrophy

Cytokeratin4
Tissue specificity
組織特異性
Detected in the suprabasal layer of the stratified epithelium of the esophagus, exocervix, vagina, mouth and lingual mucosa, and in cells and cell clusters in the mucosa and serous gland ducts of the esophageal submucosa (at protein level). Expressed widely in the exocervix and esophageal epithelium, with lowest levels detected in the basal cell layer.
Involvement in disease
関連疾患
white sponge nevus of cannon

Cytokeratin5
Involvement in disease
関連疾患
  • epidermolysis bullosa simplex Dowling-Meara type
  • epidermolysis bullosa simplex with migratory circinate erythema
  • epidermolysis bullosa simplex Weber-Cockayne type
  • epidermolysis bullosa simplex Koebner type
  • epidermolysis bullosa simplex with mottled pigmentation
  • Dowling-Degos disease

Cytokeratin6
Tissue specificity
組織特異性
Constitutively expressed in distinct types of epithelia such as those in oral mucosa, esophagus, papillae of tongue and hair follicle outer root sheath.

Cytokeratin7
Function
機能
Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7).
Tissue specificity
組織特異性
Expressed in cultured epidermal, bronchial and mesothelial cells but absent in colon, ectocervix and liver. Observed throughout the glandular cells in the junction between stomach and esophagus but is absent in the esophagus.
Cellular localization
細胞内局在性
Cytoplasm.

Cytokeratin8
Function
機能
Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
Tissue specificity
組織特異性
Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.
Cellular localization
細胞内局在性
Cytoplasm. Nucleus, nucleoplasm. Nucleus matrix.

Cytokeratin9
Function
機能
May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly.
Tissue specificity
組織特異性
Expressed in the terminally differentiated epidermis of palms and soles.
Involvement in disease
関連疾患
palmoplantar keratoderma epidermolytic

Cytokeratin10
Tissue specificity
組織特異性
Seen in all suprabasal cell layers including stratum corneum.
Involvement in disease
関連疾患
  • bullous congenital ichthyosiform erythroderma
  • ichthyosis annular epidermolytic

Cytokeratin13
Tissue specificity
組織特異性
Expressed in some epidermal sweat gland ducts (at protein level) and in exocervix, esophagus and placenta.
Involvement in disease
関連疾患
  • bullous congenital ichthyosiform erythroderma
  • ichthyosis annular epidermolytic

Cytokeratin14
Function
機能
The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro.
Tissue specificity
組織特異性
Detected in the basal layer, lowered within the more apically located layers specifically in the stratum spinosum, stratum granulosum but is not detected in stratum corneum. Strongly expressed in the outer root sheath of anagen follicles but not in the germinative matrix, inner root sheath or hair. Found in keratinocytes surrounding the club hair during telogen.
Involvement in disease
関連疾患
  • epidermolysis bullosa simplex Dowling-Meara type
  • epidermolysis bullosa simplex Weber-Cockayne type
  • epidermolysis bullosa simplex Koebner type
  • epidermolysis bullosa simplex autosomal recessive
  • Naegeli-Franceschetti-Jadassohn syndrome
  • dermatopathia pigmentosa reticularis
Cellular localization
細胞内局在性
Cytoplasm. Nucleus. Expressed in both as a filamentous pattern.

Cytokeratin15
Tissue specificity
組織特異性
Expressed in a discontinuous manner in the basal cell layer of adult skin epidermis, but continuously in the basal layer of fetal skin epidermis and nail. Also expressed in the outer root sheath above the hair bulb in hair follicle (at protein level). Expressed homogeneously in all cell layers of the esophagus and exocervix, but detected in the basal cell layer only of oral mucosa, skin and in the basal plus the next two layers of the suprabasal epithelium of the palate.

Cytokeratin16
Tissue specificity
組織特異性
Expressed in the hair follicle, nail bed and in mucosal stratified squamous epithelia and, suprabasally, in oral epithelium and palmoplantar epidermis. Also found in luminal cells of sweat and mammary gland ducts.
Involvement in disease
関連疾患
  • pachyonychia congenita type 1
  • palmoplantar keratoderma non-epidermolytic focal
  • unilateral palmoplantar verrucous nevus

Cytokeratin17
Function
機能
May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair.
Tissue specificity
組織特異性
Expressed in the outer root sheath and medulla region of hair follicle specifically from eyebrow and beard, digital pulp, nail matrix and nail bed epithelium, mucosal stratified squamous epithelia and in basal cells of oral epithelium, palmoplantar epidermis and sweat and mammary glands. Also expressed in myoepithelium of prostate, basal layer of urinary bladder, cambial cells of sebaceous gland and in exocervix (at protein level).
Involvement in disease
関連疾患
  • pachyonychia congenita type 2
  • steatocystoma multiplex
Cellular localization
細胞内局在性
Cytoplasm.

Cytokeratin18
Function
機能
Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
Tissue specificity
組織特異性
Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.
Involvement in disease
関連疾患
Defects in KRT18 are a cause of cirrhosis (CIRRH)
Cellular localization
細胞内局在性
Cytoplasm > perinuclear region.

Cytokeratin19
Function
機能
Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
Tissue specificity
組織特異性
Expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, ectocervical epithelium (at protein level). Expressed in epidermal basal cells, in nipple epidermis and a defined region of the hair follicle. Also seen in a subset of vascular wall cells in both the veins and artery of human umbilical cord, and in umbilical cord vascular smooth muscle. Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma in structures that contain dystrophin and spectrin.

Cytokeratin20
Function
機能
Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine.
Tissue specificity
組織特異性
Expressed predominantly in the intestinal epithelium. Expressed in luminal cells of colonic mucosa. Also expressed in the Merkel cells of keratinized oral mucosa; specifically at the tips of some rete ridges of the gingival mucosa, in the basal layer of the palatal mucosa and in the taste buds of lingual mucosa.
Cellular localization
細胞内局在性
Cytoplasm.

関連リンク


注目ターゲット

Cancer
ポータル

上皮間葉転換

Ki67 抗体 ~ 臨床への応用

Ki67


Alexa Fluor® is a registered trademark of Life Technologies. Alexa Fluor® dye conjugates contain(s) technology licensed to Abcam by Life Technologies.


ウサギ・モノクローナル 抗体

ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

Cytokeratin 1Hu, MS, Rat WB, IHC-P, IHC-Fr ab185628
Cytokeratin 4HuFlow Cyt, ICC, ICC/IF, IHC-P, IP, WB6 ab51599
Cytokeratin 5Hu, MsIHC-Fr, ICC/IF, Flow Cyt, IHC-P, WB8 ab214586
Cytokeratin 6 HuICC, IHC-P, WB1 ab52620
Cytokeratin 7 Hu, Ms, RatICC/IF, IHC-Fr, IHC-P, WB39ab181598
Cytokeratin 7
BSA and Azide free
Hu, Ms, Rat ICC/IF, WB, IHC-Fr, IHC-P2 ab220804
Cytokeratin 8
BSA and Azide free
Hu, MsWB, IP, IHC-P, Flow Cyt, ICC/IF14 ab217173
Cytokeratin 8+18 Ms, HuFlow Cyt, ICC/IF, IHC-P, IP, WB173 ab53280
Cytokeratin 8 (pS73)Hu, Ms, RatICC/IF, IHC-Fr, IHC-P, WB56 ab32579
Cytokeratin 10Hu, Ms, RatICC/IF, IHC-Fr, IHC-P, WB87 ab76318
Cytokeratin 10
BSA and Azide free
Hu, Ms, Rat ICC/IF, IHC-Fr, WB, IHC-P8ab220806
Cytokeratin 13 Ms, HuICC, IHC-Fr, IHC-P, WB71 ab92551
Cytokeratin 14 Hu, Ms, RatICC/IF, IHC-P, WB23 ab181595
Cytokeratin 14
Alexa Fluor® 488
HuFlow Cyt, ICC/IF2 ab192055
Cytokeratin 15Hu, MsFlow Cyt, ICC/IF, IHC-P, WB81 ab52816
Cytokeratin 16 HuFlow Cyt, ICC, IHC-P, WB91 ab76416
Cytokeratin 17Hu, Ms, RatFlow Cyt, ICC/IF, IHC-P, WB3 ab109725
Cytokeratin 18 HuFlow Cyt, ICC/IF, IHC-Fr, IHC-P, WB145 ab32118
Cytokeratin 19 Hu, MsFlow Cyt, ICC/IF, IHC-P, WB237 ab52625
Cytokeratin 19
BSA and Azide free
Hu, Ms ICC/IF, Flow Cyt, IHC-P, WB8ab195872
Cytokeratin 20Goat, Hu, Mmst, Pig, RatFlow Cyt, ICC, IHC-Fr, IHC-P, IP, WB913 ab76126
Cytokeratin 20
BSA and Azide free
Goat, Hu, Mmst, Pig, Rat Flow Cyt, ICC/IF, IP, IHC-Fr, WB, IHC-P7ab219589

抗体

ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

Acidic CytokeratinMs-M Hu, Ms, Cow, Dog, Rb, Rat, Chk, Turt, MkFlow Cyt, ICC/IF, IHC-Fr, IHC-P, WB ab187381
Cytokeratin 1Ms-MMs, Rat, Chk, Cow, Mk, Rb, TurtIHC-Fr, IHC-P, WB92 ab9286
Cytokeratin 2Ms-M Ms, Rat, Rb, Chk, Cow, Hu, Mk, PigEM, IHC-Fr, IHC-P, WB ab16111
Cytokeratin 3Ms-MHu, Cow, RbFlow Cyt, ICC/IF, IHC-P, WB51 ab77869
Cytokeratin 3+12Ms-MHu, Ms, Cow, RbICC/IF, IHC-Fr, IHC-P, WB31 ab68260
Cytokeratin 4Ms-MHu, Cat, Dog, ZfshFlow Cyt, ICC, WB6 ab9004
Cytokeratin 5Rb-PHu, Ms, Rat, PigELISA, Flow Cyt, ICC/IF, IHC-FoFr, IHC-Fr, IHC-P, WB174 ab53121
Cytokeratin 5 + 6Ms-MHuIHC-P41 ab17133
Cytokeratin 5 + 8Ms-MHu, Ms, Rat, Dog, Hm, Pig, RbDot, Flow Cyt, ICC/IF, IHC-Fr, IHC-P, WB5 ab9005
Cytokeratin 6Ms-MHu, MsFlow Cyt, ICC, IHC-Fr, IHC-P, WB3 ab18586
Cytokeratin 7Ms-MHu, Ms, Rat, Cat, Dog, Goat, Hm, Pig, ZfshFlow Cyt, ICC, ICC/IF, IHC-Fr, IHC-P, WB2312 ab9021
Cytokeratin 8Ms-MHu, Rat, RbFlow Cyt, ICC, ICC/IF, IHC-Fr, IHC-P, WB139 ab9023
Cytokeratin 8+18Ms-MHuFlow Cyt, ICC/IF, IHC-P, WB11 ab17139
Cytokeratin 10Ms-MHu, Ms, Cat, Dog, ShpFlow Cyt, ICC, IHC-Fr, IHC-P, WB133 ab9026
Cytokeratin 10 + 13Ms-M Cat, Hu, Zfsh, DogFlow Cyt, ICC, IHC-Fr, IHC-P, WB12 ab9383
Cytokeratin 13Ms-MHu, Ms, RbICC/IF, IHC-P, WB102 ab16112
Cytokeratin 15Ms-MHu, Ms, Rat, CowFlow Cyt, ICC/IF, IHC-P22 ab80522
Cytokeratin 17Rb-PHu, Ms, RatELISA, ICC, ICC/IF, IHC-P, WB81 ab53707
Cytokeratin 18Ms-M Ms, Rat, Shp, Goat, Hrs, Hm, Cow, Dog, Hu, Pig, Mmst, CatFlow Cyt, ICC, ICC/IF, IHC-Fr, IHC-P, IP, WB4219 ab668
Cytokeratin 19Ms-MHuELISA, Flow Cyt, ICC, ICC/IF, IHC-Fr, IHC-P, IP, WB167 ab7754

タンパク質・ペプチド

製品名

由来

適用・アプリケーション

製品番号

Cytokeratin 1 protein HuELISA, SDS-PAGE, WBab114282
Cytokeratin 7 proteinHuELISA, SDS-PAGE, WBab132933
Cytokeratin 8 proteinHuSDS-PAGEab156970
Cytokeratin 10 protein HuELISA, SDS-PAGE, WBab114223
Cytokeratin 13 proteinHuELISA, SDS-PAGE, WBab112315
Cytokeratin 16 protein HuELISA, SDS-PAGE, WBab114405
Cytokeratin 17 proteinHuELISA, SDS-PAGE, WBab116974
Cytokeratin 18 proteinHuSDS-PAGE, WBab73638
タンパク質・ペプチド一覧

キット

製品名

交差種

容量

製品番号

Cytokeratin 14 Matched 抗体 Pair KitHu2 x 96 tests
10 x 96 tests
ab221423
キット一覧

ライゼート

製品名

適用・アプリケーション

製品番号

Cytokeratin 4 293T Transfected Lysate - (positive control)WBab94137
Cytokeratin 17 293T Transfected Lysate - (positive control)WBab94233
Cytokeratin 19 293T Transfected Lysate - (positive control)WBab94060

Cytokeratin について

Cytokeratin1
Function
機能
May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein kinase C (RACK1/GNB2L1).
Tissue specificity
組織特異性
The source of this protein is neonatal foreskin. The 67-kDa type II keratins are expressed in terminally differentiating epidermis.
Involvement in disease
関連疾患
  • bullous congenital ichthyosiform erythroderma
  • ichthyosis hystrix Curth-Macklin type
  • palmoplantar keratoderma non-epidermolytic
  • ichthyosis annular epidermolytic
  • palmoplantar keratoderma striate type 3
Cellular localization
細胞内局在性
Cell membrane. Located on plasma membrane of neuroblastoma NMB7 cells.

Cytokeratin2
Function
機能
Probably contributes to terminal cornification.

Cytokeratin3
Tissue specificity
組織特異性
Cornea specific.
Involvement in disease
関連疾患
Meesmann corneal dystrophy

Cytokeratin4
Tissue specificity
組織特異性
Detected in the suprabasal layer of the stratified epithelium of the esophagus, exocervix, vagina, mouth and lingual mucosa, and in cells and cell clusters in the mucosa and serous gland ducts of the esophageal submucosa (at protein level). Expressed widely in the exocervix and esophageal epithelium, with lowest levels detected in the basal cell layer.
Involvement in disease
関連疾患
white sponge nevus of cannon

Cytokeratin5
Involvement in disease
関連疾患
  • epidermolysis bullosa simplex Dowling-Meara type
  • epidermolysis bullosa simplex with migratory circinate erythema
  • epidermolysis bullosa simplex Weber-Cockayne type
  • epidermolysis bullosa simplex Koebner type
  • epidermolysis bullosa simplex with mottled pigmentation
  • Dowling-Degos disease

Cytokeratin6
Tissue specificity
組織特異性
Constitutively expressed in distinct types of epithelia such as those in oral mucosa, esophagus, papillae of tongue and hair follicle outer root sheath.

Cytokeratin7
Function
機能
Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7).
Tissue specificity
組織特異性
Expressed in cultured epidermal, bronchial and mesothelial cells but absent in colon, ectocervix and liver. Observed throughout the glandular cells in the junction between stomach and esophagus but is absent in the esophagus.
Cellular localization
細胞内局在性
Cytoplasm.

Cytokeratin8
Function
機能
Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
Tissue specificity
組織特異性
Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.
Cellular localization
細胞内局在性
Cytoplasm. Nucleus, nucleoplasm. Nucleus matrix.

Cytokeratin9
Function
機能
May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly.
Tissue specificity
組織特異性
Expressed in the terminally differentiated epidermis of palms and soles.
Involvement in disease
関連疾患
palmoplantar keratoderma epidermolytic

Cytokeratin10
Tissue specificity
組織特異性
Seen in all suprabasal cell layers including stratum corneum.
Involvement in disease
関連疾患
  • bullous congenital ichthyosiform erythroderma
  • ichthyosis annular epidermolytic

Cytokeratin13
Tissue specificity
組織特異性
Expressed in some epidermal sweat gland ducts (at protein level) and in exocervix, esophagus and placenta.
Involvement in disease
関連疾患
  • bullous congenital ichthyosiform erythroderma
  • ichthyosis annular epidermolytic

Cytokeratin14
Function
機能
The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro.
Tissue specificity
組織特異性
Detected in the basal layer, lowered within the more apically located layers specifically in the stratum spinosum, stratum granulosum but is not detected in stratum corneum. Strongly expressed in the outer root sheath of anagen follicles but not in the germinative matrix, inner root sheath or hair. Found in keratinocytes surrounding the club hair during telogen.
Involvement in disease
関連疾患
  • epidermolysis bullosa simplex Dowling-Meara type
  • epidermolysis bullosa simplex Weber-Cockayne type
  • epidermolysis bullosa simplex Koebner type
  • epidermolysis bullosa simplex autosomal recessive
  • Naegeli-Franceschetti-Jadassohn syndrome
  • dermatopathia pigmentosa reticularis
Cellular localization
細胞内局在性
Cytoplasm. Nucleus. Expressed in both as a filamentous pattern.

Cytokeratin15
Tissue specificity
組織特異性
Expressed in a discontinuous manner in the basal cell layer of adult skin epidermis, but continuously in the basal layer of fetal skin epidermis and nail. Also expressed in the outer root sheath above the hair bulb in hair follicle (at protein level). Expressed homogeneously in all cell layers of the esophagus and exocervix, but detected in the basal cell layer only of oral mucosa, skin and in the basal plus the next two layers of the suprabasal epithelium of the palate.

Cytokeratin16
Tissue specificity
組織特異性
Expressed in the hair follicle, nail bed and in mucosal stratified squamous epithelia and, suprabasally, in oral epithelium and palmoplantar epidermis. Also found in luminal cells of sweat and mammary gland ducts.
Involvement in disease
関連疾患
  • pachyonychia congenita type 1
  • palmoplantar keratoderma non-epidermolytic focal
  • unilateral palmoplantar verrucous nevus

Cytokeratin17
Function
機能
May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair.
Tissue specificity
組織特異性
Expressed in the outer root sheath and medulla region of hair follicle specifically from eyebrow and beard, digital pulp, nail matrix and nail bed epithelium, mucosal stratified squamous epithelia and in basal cells of oral epithelium, palmoplantar epidermis and sweat and mammary glands. Also expressed in myoepithelium of prostate, basal layer of urinary bladder, cambial cells of sebaceous gland and in exocervix (at protein level).
Involvement in disease
関連疾患
  • pachyonychia congenita type 2
  • steatocystoma multiplex
Cellular localization
細胞内局在性
Cytoplasm.

Cytokeratin18
Function
機能
Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
Tissue specificity
組織特異性
Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.
Involvement in disease
関連疾患
Defects in KRT18 are a cause of cirrhosis (CIRRH)
Cellular localization
細胞内局在性
Cytoplasm > perinuclear region.

Cytokeratin19
Function
機能
Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
Tissue specificity
組織特異性
Expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, ectocervical epithelium (at protein level). Expressed in epidermal basal cells, in nipple epidermis and a defined region of the hair follicle. Also seen in a subset of vascular wall cells in both the veins and artery of human umbilical cord, and in umbilical cord vascular smooth muscle. Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma in structures that contain dystrophin and spectrin.

Cytokeratin20
Function
機能
Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine.
Tissue specificity
組織特異性
Expressed predominantly in the intestinal epithelium. Expressed in luminal cells of colonic mucosa. Also expressed in the Merkel cells of keratinized oral mucosa; specifically at the tips of some rete ridges of the gingival mucosa, in the basal layer of the palatal mucosa and in the taste buds of lingual mucosa.
Cellular localization
細胞内局在性
Cytoplasm.

関連リンク


注目ターゲット

Cancer
ポータル

上皮間葉転換

Ki67 抗体 ~ 臨床への応用

Ki67


Alexa Fluor® is a registered trademark of Life Technologies. Alexa Fluor® dye conjugates contain(s) technology licensed to Abcam by Life Technologies.

コメント (承認されるまでコメントは表示されません)
登録