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KAT3A / CBP ~ 注目ターゲットのおすすめ製品


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ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

KAT3A / CBPRb-P Ms, Hu, RatChIP, CHIPseq, IHC-P, Inhib, IP, WB194 ab2832
KAT3A / CBPMs-M
Hu, MsDot, ICC/IF, IHC-P, IP, WB11 ab50702
KAT3A / CBPRb-P HuChIP, IP1 ab10489
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タンパク質・ペプチド

製品名

由来

適用・アプリケーション

製品番号

KAT3A / CBP protein (Active )HuFuncS, SDS-PAGE, WBab167964
KAT3A / CBP protein (Active )HuFuncS, SDS-PAGEab198130
KAT3A / CBP protein fragmentHuSDS-PAGEab198144
タンパク質・ペプチド一覧

KAT3A / CBP について

Function
機能
Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 coactivator. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300.
Involvement in disease
関連疾患
Note=Chromosomal aberrations involving CREBBP may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with MYST3/MOZ; translocation t(11;16)(q23;p13.3) with MLL/HRX; translocation t(10;16)(q22;p13) with MYST4/MORF. MYST3-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription. Defects in CREBBP are a cause of Rubinstein-Taybi syndrome type 1 (RSTS1) [MIM:180849]. RSTS1 is an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies.
Sequence similarities
配列類似性
  • Contains 1 bromo domain.
  • Contains 1 KIX domain.
  • Contains 2 TAZ-type zinc fingers.
  • Contains 1 ZZ-type zinc finger.
Post-translational modifications
翻訳後修飾
Methylation of the KIX domain by CARM1 blocks association with CREB. This results in the blockade of CREB signaling, and in activation of apoptotic response. Phosphorylated upon DNA damage, probably by ATM or ATR. Sumoylation negatively regulates transcriptional activity via the recruitment of DAAX.
Cellular localization
細胞内局在性
Cytoplasm. Nucleus. Recruited to nuclear bodies by SS18L1/CREST. In the presence of ALX1 relocalizes from the cytoplasm to the nucleus.

関連リンク


注目ターゲット

Epigenetics
ポータル


抗体

ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

KAT3A / CBPRb-P Ms, Hu, RatChIP, CHIPseq, IHC-P, Inhib, IP, WB194 ab2832
KAT3A / CBPMs-M
Hu, MsDot, ICC/IF, IHC-P, IP, WB11 ab50702
KAT3A / CBPRb-P HuChIP, IP1 ab10489
抗体一覧

タンパク質・ペプチド

製品名

由来

適用・アプリケーション

製品番号

KAT3A / CBP protein (Active )HuFuncS, SDS-PAGE, WBab167964
KAT3A / CBP protein (Active )HuFuncS, SDS-PAGEab198130
KAT3A / CBP protein fragmentHuSDS-PAGEab198144
タンパク質・ペプチド一覧

KAT3A / CBP について

Function
機能
Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 coactivator. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300.
Involvement in disease
関連疾患
Note=Chromosomal aberrations involving CREBBP may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with MYST3/MOZ; translocation t(11;16)(q23;p13.3) with MLL/HRX; translocation t(10;16)(q22;p13) with MYST4/MORF. MYST3-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription. Defects in CREBBP are a cause of Rubinstein-Taybi syndrome type 1 (RSTS1) [MIM:180849]. RSTS1 is an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies.
Sequence similarities
配列類似性
  • Contains 1 bromo domain.
  • Contains 1 KIX domain.
  • Contains 2 TAZ-type zinc fingers.
  • Contains 1 ZZ-type zinc finger.
Post-translational modifications
翻訳後修飾
Methylation of the KIX domain by CARM1 blocks association with CREB. This results in the blockade of CREB signaling, and in activation of apoptotic response. Phosphorylated upon DNA damage, probably by ATM or ATR. Sumoylation negatively regulates transcriptional activity via the recruitment of DAAX.
Cellular localization
細胞内局在性
Cytoplasm. Nucleus. Recruited to nuclear bodies by SS18L1/CREST. In the presence of ALX1 relocalizes from the cytoplasm to the nucleus.

関連リンク


注目ターゲット

Epigenetics
ポータル

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