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Trk ~ 注目ターゲットのおすすめ製品


ウサギ・モノクローナル 抗体

ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

TrkAHu, Ms, RatFlow Cyt, ICC/IF, IHC-P, IP, WB1010 ab76291
TrkB ab187041
TrkB HuIHC-P, IP, WB1 ab134155
TrkA
Alexa Fluor® 488
Ms, Rat, HuICC/IF ab194321
TrkA
Alexa Fluor® 647
Ms, Rat, HuICC/IF ab194322

抗体

ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

TrkBRb-PHu, Ms, Rat, ChkICC/IF, IHC-P, IP, WB129ab18987
TrkBRb-P Ms, HuELISA, WB34 ab109684
TrkCRb-PHu, Ms, RatICC/IF, IHC-Fr31 ab43078
抗体一覧

タンパク質・ペプチド

製品名

由来

適用・アプリケーション

製品番号

TrkA protein (Active)FuncS, SDS-PAGEab205799
TrkB protein(Active)HuFuncS, SDS-PAGEab56652
TrkC protein(Active)HuFuncS, SDS-PAGEab196087
TrkB proteinHuELISA, SDS-PAGE, WBab132927
TrkC protein (Fc Chimera)FuncS, SDS-PAGEab85599
TrkA protein (Fc Chimera)SDS-PAGEab83562
タンパク質・ペプチド一覧

キット

製品名

交差種

容量

製品番号

TrkA Rat ELISA KitRat1×96testsab119609
Mouse TrkB ELISA Kit SimpleStep Ms1×96testsab203368
キット一覧

生理活性物質

製品名

解説

製品番号

7,8-Dihydroxyflavone (7,8-DHF)Selective TrkB receptor agonist. Flavonoid.ab120996
AG-879 Selective TrkA receptor inhibitorab141059
GW-441756 hydrochloride Potent, selective TrKA receptor tyrosine kinase inhibitorab141051
Gambogic amide Potent, selective high affinity nerve growth factor (TrKa) receptor agonistab141702
Lestaurtinib Potent JAK2, FLT3 and TrkA receptor tyrosine kinase inhibitorab142107
ANA-12TrkB antagonist ab146196
LM22A-4 Neurotrophic BDNF mimetic; Partial TrkB agonist.ab222020
PHA-848125Potent, ATP-competitive CDK2 and TRKA inhibitor ab219472

Trk について

Trk A
Function
機能
Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors. Isoform TrkA-III is resistant to NGF, constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed.
Tissue specificity
組織特異性
Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by pluripotent neural stem and neural crest progenitors.
Cellular localization
細胞内局在性
Cell membrane. Early endosome membrane. Late endosome membrane. Internalized to endosomes upon binding of NGF or NTF3 and further transported to the cell body via a retrograde axonal transport. Localized at cell membrane and early endosomes before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Colocalized with RAPGEF2 at late endosomes (By similarity).
Trk B
Function
機能
Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.
Tissue specificity
組織特異性
Isoform TrkB is widely expressed, mainly in the nervous tissue. In the CNS, expression is observed in the cerebral cortex, hippocampus, thalamus, choroid plexus, granular layer of the cerebellum, brain stem, and spinal cord. In the peripheral nervous system, it is expressed in many cranial ganglia, the ophtalmic nerve, the vestibular system, multiple facial structures, the submaxillary glands, and dorsal root ganglia. Isoform TrkB-T1 is expressed in multiple tissues, mainly in brain, pancreas, kidney and heart. Isoform TrkB-T-Shc is predominantly expressed in brain.
Cellular localization
細胞内局在性
Membrane.
Trk C
Function
機能
Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.
Tissue specificity
組織特異性
Widely expressed but mainly in nervous tissue. Isoform B is expressed at higher levels in adult brain than in fetal brain.
Cellular localization
細胞内局在性
Membrane.

関連リンク


注目ターゲット

Neuroscience
ポータル



Alexa Fluor® is a registered trademark of Life Technologies. Alexa Fluor® dye conjugates contain(s) technology licensed to Abcam by Life Technologies.


ウサギ・モノクローナル 抗体

ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

TrkAHu, Ms, RatFlow Cyt, ICC/IF, IHC-P, IP, WB1010 ab76291
TrkB ab187041
TrkB HuIHC-P, IP, WB1 ab134155
TrkA
Alexa Fluor® 488
Ms, Rat, HuICC/IF ab194321
TrkA
Alexa Fluor® 647
Ms, Rat, HuICC/IF ab194322

抗体

ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

TrkBRb-PHu, Ms, Rat, ChkICC/IF, IHC-P, IP, WB129ab18987
TrkBRb-P Ms, HuELISA, WB34 ab109684
TrkCRb-PHu, Ms, RatICC/IF, IHC-Fr31 ab43078
抗体一覧

タンパク質・ペプチド

製品名

由来

適用・アプリケーション

製品番号

TrkA protein (Active)FuncS, SDS-PAGEab205799
TrkB protein(Active)HuFuncS, SDS-PAGEab56652
TrkC protein(Active)HuFuncS, SDS-PAGEab196087
TrkB proteinHuELISA, SDS-PAGE, WBab132927
TrkC protein (Fc Chimera)FuncS, SDS-PAGEab85599
TrkA protein (Fc Chimera)SDS-PAGEab83562
タンパク質・ペプチド一覧

キット

製品名

交差種

容量

製品番号

TrkA Rat ELISA KitRat1×96testsab119609
Mouse TrkB ELISA Kit SimpleStep Ms1×96testsab203368
キット一覧

生理活性物質

製品名

解説

製品番号

7,8-Dihydroxyflavone (7,8-DHF)Selective TrkB receptor agonist. Flavonoid.ab120996
AG-879 Selective TrkA receptor inhibitorab141059
GW-441756 hydrochloride Potent, selective TrKA receptor tyrosine kinase inhibitorab141051
Gambogic amide Potent, selective high affinity nerve growth factor (TrKa) receptor agonistab141702
Lestaurtinib Potent JAK2, FLT3 and TrkA receptor tyrosine kinase inhibitorab142107
ANA-12TrkB antagonist ab146196
LM22A-4 Neurotrophic BDNF mimetic; Partial TrkB agonist.ab222020
PHA-848125Potent, ATP-competitive CDK2 and TRKA inhibitor ab219472

Trk について

Trk A
Function
機能
Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors. Isoform TrkA-III is resistant to NGF, constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed.
Tissue specificity
組織特異性
Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by pluripotent neural stem and neural crest progenitors.
Cellular localization
細胞内局在性
Cell membrane. Early endosome membrane. Late endosome membrane. Internalized to endosomes upon binding of NGF or NTF3 and further transported to the cell body via a retrograde axonal transport. Localized at cell membrane and early endosomes before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Colocalized with RAPGEF2 at late endosomes (By similarity).
Trk B
Function
機能
Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.
Tissue specificity
組織特異性
Isoform TrkB is widely expressed, mainly in the nervous tissue. In the CNS, expression is observed in the cerebral cortex, hippocampus, thalamus, choroid plexus, granular layer of the cerebellum, brain stem, and spinal cord. In the peripheral nervous system, it is expressed in many cranial ganglia, the ophtalmic nerve, the vestibular system, multiple facial structures, the submaxillary glands, and dorsal root ganglia. Isoform TrkB-T1 is expressed in multiple tissues, mainly in brain, pancreas, kidney and heart. Isoform TrkB-T-Shc is predominantly expressed in brain.
Cellular localization
細胞内局在性
Membrane.
Trk C
Function
機能
Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.
Tissue specificity
組織特異性
Widely expressed but mainly in nervous tissue. Isoform B is expressed at higher levels in adult brain than in fetal brain.
Cellular localization
細胞内局在性
Membrane.

関連リンク


注目ターゲット

Neuroscience
ポータル



Alexa Fluor® is a registered trademark of Life Technologies. Alexa Fluor® dye conjugates contain(s) technology licensed to Abcam by Life Technologies.

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