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HNF ~ 注目ターゲットのおすすめ製品


ウサギ・モノクローナル 抗体

ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

HNF1 beta HuIHC-P ab213149
HNF1 alpha+HNF1 beta HuIHC-P ab209666
HNF4 alpha Hu, Ms, RatChIP, IHC-P, IP, WB ab181604
HNF4 alpha Hu, Ms, RatFlow Cyt, WB, IHC-P, ICC/IF ab201460
HNF6 Hu, Ms, RatWB ab186743

抗体

ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

HNF1 alphaRb-P HuICC/IF, IHC-P, WB ab204306
HNF1 betaGoat-PHuELISA, ICC/IF, WB1 ab59118
HNF4 alpha (pS304)Rb-P Ms, Rat, HuWB ab194930
HNF4 alpha (pS313)Rb-PHuELISA, ICC/IF, IHC-P, WB ab78356
HNF6Rb-P HuELISA, IHC-P, WB1 ab83564
抗体一覧

タンパク質・ペプチド

製品名

由来

適用・アプリケーション

製品番号

HNF1 beta proteinHuELISA, SDS-PAGE, WBab116782
HNF4 alpha protein HuELISA, SDS-PAGE, WBab114232
HNF4 gamma protein HuELISA, SDS-PAGE, WBab116986
HNF6 full length proteinHuDot, ELISA, SDS-PAGE, WBab98300
タンパク質・ペプチド一覧

キット

製品名

交差種

容量

製品番号

HNF-4-alpha ELISA Kit Hu1×96testsab210581
HNF (HNF1, HNF3alpha, HNF3beta, HNF4alpha) Transcription Factor Assay KitHu,Ms,Rat2×96testsab207208
HNF1 Transcription Factor Assay KitHu,Ms,Rat1×96tests
5×96tests
ab207209

HNF について

HNF1 alpha
Function
機能
Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Required for the expression of several liver specific genes. Binds to the inverted palindrome 5'-GTTAATNATTAAC-3'.
Tissue specificity
組織特異性
Liver
Involvement in disease
疾患関連性
  • Defects in HNF1A are a cause of hepatic adenomas familial (HEPAF) .
  • Defects in HNF1A are the cause of maturity-onset diabetes of the young type 3 (MODY3) .
  • Defects in HNF1A are the cause of susceptibility to diabetes mellitus insulin-dependent type 20 (IDDM20) .
Sequence similarities
配列類似性
  • Belongs to the HNF1 homeobox family.
  • Contains 1 homeobox DNA-binding domain.
Cellular localization
細胞内局在性
Nucleus.
HNF1 beta
Function
機能
Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'.
Involvement in disease
疾患関連性
  • Defects in HNF1B are the cause of renal cysts and diabetes syndrome (RCAD).
  • Defects in HNF1B may be rare genetic risk factor contributing to the development of non-insulin-dependent diabetes mellitus (NIDDM).
  • Defects in HNF1B may be a cause of susceptibility to prostate cancer hereditary type 11 (HPC11).
Sequence similarities
配列類似性
  • Belongs to the HNF1 homeobox family.
  • Contains 1 homeobox DNA-binding domain.
Cellular localization
細胞内局在性
Nucleus.
HNF4 alpha
Function
機能
Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1-antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1-alpha. May be essential for development of the liver, kidney and intestine.
Involvement in disease
疾患関連性
Defects in HNF4A are the cause of maturity-onset diabetes of the young type 1 (MODY1) .
Sequence similarities
配列類似性
  • Belongs to the nuclear hormone receptor family. NR2 subfamily.
  • Contains 1 nuclear receptor DNA-binding domain.
Post-translational modifications
翻訳後修飾
Phosphorylated on tyrosine residue(s); phosphorylation is important for its DNA-binding activity. Phosphorylation may directly or indirectly play a regulatory role in the subnuclear distribution.
Cellular localization
細胞内局在性
Nucleus.
HNF6
Function
機能
Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription.
Tissue specificity
組織特異性
Highly expressed in liver; lower expression in testis and skin.
Sequence similarities
配列類似性
  • Belongs to the CUT homeobox family.
  • Contains 1 CUT DNA-binding domain.
  • Contains 1 homeobox DNA-binding domain.
Cellular localization
細胞内局在性
Nucleus.

関連リンク


注目ターゲット




ウサギ・モノクローナル 抗体

ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

HNF1 beta HuIHC-P ab213149
HNF1 alpha+HNF1 beta HuIHC-P ab209666
HNF4 alpha Hu, Ms, RatChIP, IHC-P, IP, WB ab181604
HNF4 alpha Hu, Ms, RatFlow Cyt, WB, IHC-P, ICC/IF ab201460
HNF6 Hu, Ms, RatWB ab186743

抗体

ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

HNF1 alphaRb-P HuICC/IF, IHC-P, WB ab204306
HNF1 betaGoat-PHuELISA, ICC/IF, WB1 ab59118
HNF4 alpha (pS304)Rb-P Ms, Rat, HuWB ab194930
HNF4 alpha (pS313)Rb-PHuELISA, ICC/IF, IHC-P, WB ab78356
HNF6Rb-P HuELISA, IHC-P, WB1 ab83564
抗体一覧

タンパク質・ペプチド

製品名

由来

適用・アプリケーション

製品番号

HNF1 beta proteinHuELISA, SDS-PAGE, WBab116782
HNF4 alpha protein HuELISA, SDS-PAGE, WBab114232
HNF4 gamma protein HuELISA, SDS-PAGE, WBab116986
HNF6 full length proteinHuDot, ELISA, SDS-PAGE, WBab98300
タンパク質・ペプチド一覧

キット

製品名

交差種

容量

製品番号

HNF-4-alpha ELISA Kit Hu1×96testsab210581
HNF (HNF1, HNF3alpha, HNF3beta, HNF4alpha) Transcription Factor Assay KitHu,Ms,Rat2×96testsab207208
HNF1 Transcription Factor Assay KitHu,Ms,Rat1×96tests
5×96tests
ab207209

HNF について

HNF1 alpha
Function
機能
Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Required for the expression of several liver specific genes. Binds to the inverted palindrome 5'-GTTAATNATTAAC-3'.
Tissue specificity
組織特異性
Liver
Involvement in disease
疾患関連性
  • Defects in HNF1A are a cause of hepatic adenomas familial (HEPAF) .
  • Defects in HNF1A are the cause of maturity-onset diabetes of the young type 3 (MODY3) .
  • Defects in HNF1A are the cause of susceptibility to diabetes mellitus insulin-dependent type 20 (IDDM20) .
Sequence similarities
配列類似性
  • Belongs to the HNF1 homeobox family.
  • Contains 1 homeobox DNA-binding domain.
Cellular localization
細胞内局在性
Nucleus.
HNF1 beta
Function
機能
Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'.
Involvement in disease
疾患関連性
  • Defects in HNF1B are the cause of renal cysts and diabetes syndrome (RCAD).
  • Defects in HNF1B may be rare genetic risk factor contributing to the development of non-insulin-dependent diabetes mellitus (NIDDM).
  • Defects in HNF1B may be a cause of susceptibility to prostate cancer hereditary type 11 (HPC11).
Sequence similarities
配列類似性
  • Belongs to the HNF1 homeobox family.
  • Contains 1 homeobox DNA-binding domain.
Cellular localization
細胞内局在性
Nucleus.
HNF4 alpha
Function
機能
Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1-antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1-alpha. May be essential for development of the liver, kidney and intestine.
Involvement in disease
疾患関連性
Defects in HNF4A are the cause of maturity-onset diabetes of the young type 1 (MODY1) .
Sequence similarities
配列類似性
  • Belongs to the nuclear hormone receptor family. NR2 subfamily.
  • Contains 1 nuclear receptor DNA-binding domain.
Post-translational modifications
翻訳後修飾
Phosphorylated on tyrosine residue(s); phosphorylation is important for its DNA-binding activity. Phosphorylation may directly or indirectly play a regulatory role in the subnuclear distribution.
Cellular localization
細胞内局在性
Nucleus.
HNF6
Function
機能
Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription.
Tissue specificity
組織特異性
Highly expressed in liver; lower expression in testis and skin.
Sequence similarities
配列類似性
  • Belongs to the CUT homeobox family.
  • Contains 1 CUT DNA-binding domain.
  • Contains 1 homeobox DNA-binding domain.
Cellular localization
細胞内局在性
Nucleus.

関連リンク


注目ターゲット



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