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c-Fos ~ 注目ターゲットのおすすめ製品


ウサギ・モノクローナル 抗体

ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

c-FosHu, Ms, RatFlow Cyt, WB73 ab134122
c-Fos Ms, Rat, HuFlow Cyt, WB6 ab218578
c-Fos Hu, MsICC/IF, IP, WB ab214672
c-Fos HuWB ab194148

抗体

ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

c-FosRb-P Hu, Ms, RatICC/IF, IHC-P, WB2 1 ab209794
c-FosMs-M Hu, Ms, Rat, Cow, Hrs, Pig IHC-FoFr, IHC-P, WB, ICC/IF1 2 ab208942
c-Fos (p S362) Rb-PHu, Ms, RatELISA, Flow Cyt, IHC-P1 ab63444
c-Fos (p T325) Rb-PHu, Ms, RatIP, WB4ab27793
抗体一覧

タンパク質・ペプチド

製品名

由来

適用・アプリケーション

製品番号

c-Fos protein(Recombinant)HuFuncS, SDS-PAGE, WBab56280
c-Fos protein(Recombinant)HuSDS-PAGEab84143
c-Fos peptideHuab60297
c-Fos peptide (phospho T232) HuBLab43652

キット

製品名

交差種

容量

製品番号

c-Fos Transcription Factor Assay KitHu,Ms,Rat5x96tests
1x96tests
ab207194

c-Fos について

Function
機能
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation.
Sequence similarities
配列類似性
  • Belongs to the bZIP family.
  • Fos subfamily.
  • Contains 1 bZIP domain.
Post-translational modifications
翻訳後修飾
Phosphorylated in the C-terminal upon stimulation by nerve growth factor (NGF) and epidermal growth factor (EGF). Phosphorylated, in vitro, by MAPK and RSK1. Phosphorylation on both Ser-362 and Ser-374 by MAPK1/2 and RSK1/2 leads to protein stabilization with phosphorylation on Ser-374 being the major site for protein stabilization on NGF stimulation. Phosphorylation on Ser-362 and Ser-374 primes further phosphorylations on Thr-325 and Thr-331 through promoting docking of MAPK to the DEF domain. Phosphorylation on Thr-232, induced by HA-RAS, activates the transcriptional activity and antagonizes sumoylation. Phosphorylation on Ser-362 by RSK2 in osteoblasts contributes to osteoblast transformation. Constitutively sumoylated by SUMO1, SUMO2 and SUMO3. Desumoylated by SENP2. Sumoylation requires heterodimerization with JUN and is enhanced by mitogen stimulation. Sumoylation inhibits the AP-1 transcriptional activity and is, itself, inhibited by Ras-activated phosphorylation on Thr-232.
Cellular localization
細胞内局在性
Nucleus.

関連リンク


Neuroscience
ポータル

Epigenetics
ポータル

注目ターゲット


ウサギ・モノクローナル 抗体

ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

c-FosHu, Ms, RatFlow Cyt, WB73 ab134122
c-Fos Ms, Rat, HuFlow Cyt, WB6 ab218578
c-Fos Hu, MsICC/IF, IP, WB ab214672
c-Fos HuWB ab194148

抗体

ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

c-FosRb-P Hu, Ms, RatICC/IF, IHC-P, WB2 1 ab209794
c-FosMs-M Hu, Ms, Rat, Cow, Hrs, Pig IHC-FoFr, IHC-P, WB, ICC/IF1 2 ab208942
c-Fos (p S362) Rb-PHu, Ms, RatELISA, Flow Cyt, IHC-P1 ab63444
c-Fos (p T325) Rb-PHu, Ms, RatIP, WB4ab27793
抗体一覧

タンパク質・ペプチド

製品名

由来

適用・アプリケーション

製品番号

c-Fos protein(Recombinant)HuFuncS, SDS-PAGE, WBab56280
c-Fos protein(Recombinant)HuSDS-PAGEab84143
c-Fos peptideHuab60297
c-Fos peptide (phospho T232) HuBLab43652

キット

製品名

交差種

容量

製品番号

c-Fos Transcription Factor Assay KitHu,Ms,Rat5x96tests
1x96tests
ab207194

c-Fos について

Function
機能
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation.
Sequence similarities
配列類似性
  • Belongs to the bZIP family.
  • Fos subfamily.
  • Contains 1 bZIP domain.
Post-translational modifications
翻訳後修飾
Phosphorylated in the C-terminal upon stimulation by nerve growth factor (NGF) and epidermal growth factor (EGF). Phosphorylated, in vitro, by MAPK and RSK1. Phosphorylation on both Ser-362 and Ser-374 by MAPK1/2 and RSK1/2 leads to protein stabilization with phosphorylation on Ser-374 being the major site for protein stabilization on NGF stimulation. Phosphorylation on Ser-362 and Ser-374 primes further phosphorylations on Thr-325 and Thr-331 through promoting docking of MAPK to the DEF domain. Phosphorylation on Thr-232, induced by HA-RAS, activates the transcriptional activity and antagonizes sumoylation. Phosphorylation on Ser-362 by RSK2 in osteoblasts contributes to osteoblast transformation. Constitutively sumoylated by SUMO1, SUMO2 and SUMO3. Desumoylated by SENP2. Sumoylation requires heterodimerization with JUN and is enhanced by mitogen stimulation. Sumoylation inhibits the AP-1 transcriptional activity and is, itself, inhibited by Ras-activated phosphorylation on Thr-232.
Cellular localization
細胞内局在性
Nucleus.

関連リンク


Neuroscience
ポータル

Epigenetics
ポータル

注目ターゲット

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