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MDM2 ~ 注目ターゲットのおすすめ製品


ウサギ・モノクローナル 抗体

ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

MDM2 Hu, Ms, RatIHC-P, IP, WB ab222518
MDM2
(pS166)
Hu, RatIHC-P, WB3 ab170880

抗体

ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

MDM2Ms-MHu, MsFlow Cyt, ICC, ICC/IF, IHC-Fr, IHC-P, IP, WB385 ab16895
MDM2Rb-PHu, Ms, Rat, AGMk, Cow, Dog, SHmICC/IF, IHC-P, WB722 ab38618
MDM2Rb-P HuICC/IF, IHC-P, WB ab131355
MDM2(pS186)Ms-MHuWB11 ab22710
MDM2
Alexa Fluor® 488
Ms-M HuICC/IF ab216075
MDM2
Alexa Fluor® 647
Ms-M HuICC/IF ab216076
抗体一覧

タンパク質・ペプチド

製品名

由来

適用・アプリケーション

製品番号

MDM2 protein(Recombinant)(Active )HuFuncS, SDS-PAGEab188727
MDM2 protein(Recombinant)(Active )HuFuncS, SDS-PAGEab188732
MDM2 protein (Recombinant)HuSDS-PAGE, WBab167941
MDM2 protein(Recombinant)HuWBab71353
MDM2 protein(Recombinant)HuSDS-PAGEab82080
MDM2 peptideHuab48039

生理活性物質

製品名

解説

製品番号

(±)-Nutlin-3Potent, selective MDM2 antagonistab120646
(+)-Nutlin-3p53-MDM2 binding inhibitorab144426
(-)-Nutlin-3Potent p53-MDM2 binding inhibitorab144428
Caylin-1MDM2 inhibitorab144458
Lithocholic acidEndogenous MDM2 and MDM4 selective inhibitor. Detergent.ab145598
NSC 66811Potent, cell-permeable MDM2 inhibitorab142190

MDM2 について

Function
機能
E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as an ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways.
Tissue specificity
組織特異性
Ubiquitous. Isoform Mdm2-A, isoform Mdm2-B, isoform Mdm2-C, isoform Mdm2-D, isoform Mdm2-E, isoform Mdm2-F and isoform Mdm2-G are observed in a range of cancers but absent in normal tissues.
Involvement in disease
疾患関連性
Note=Seems to be amplified in certain tumors (including soft tissue sarcomas, osteosarcomas and gliomas). A higher frequency of splice variants lacking p53 binding domain sequences was found in late-stage and high-grade ovarian and bladder carcinomas. Four of the splice variants show loss of p53 binding.
Sequence similarities
配列類似性
  • Belongs to the MDM2/MDM4 family.
  • Contains 1 RanBP2-type zinc finger.
  • Contains 1 RING-type zinc finger.
  • Contains 1 SWIB domain.
Post-translational modifications
翻訳後修飾
Phosphorylated in response to ionizing radiation in an ATM-dependent manner. Auto-ubiquitinated; which leads to proteasomal degradation. Deubiquitinated by USP2 leads to its accumulation and increases deubiquitinilation and degradation of p53/TP53. Deubiquitinated by USP7; leading to stabilize it.
Cellular localization
細胞内局在性
Nucleus > nucleoplasm. Cytoplasm. Nucleus > nucleolus. Expressed predominantly in the nucleoplasm. Interaction with ARF(P14) results in the localization of both proteins to the nucleolus. The nucleolar localization signals in both ARF(P14) and MDM2 may be necessary to allow efficient nucleolar localization of both proteins. Colocalizes with RASSF1 isoform A in the nucleus.

関連リンク


Cancer
ポータル

注目ターゲット

p53 ~ 注目ターゲット
のおすすめ製品


ウサギ・モノクローナル 抗体

ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

MDM2 Hu, Ms, RatIHC-P, IP, WB ab222518
MDM2
(pS166)
Hu, RatIHC-P, WB3 ab170880

抗体

ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

MDM2Ms-MHu, MsFlow Cyt, ICC, ICC/IF, IHC-Fr, IHC-P, IP, WB385 ab16895
MDM2Rb-PHu, Ms, Rat, AGMk, Cow, Dog, SHmICC/IF, IHC-P, WB722 ab38618
MDM2Rb-P HuICC/IF, IHC-P, WB ab131355
MDM2(pS186)Ms-MHuWB11 ab22710
MDM2
Alexa Fluor® 488
Ms-M HuICC/IF ab216075
MDM2
Alexa Fluor® 647
Ms-M HuICC/IF ab216076
抗体一覧

タンパク質・ペプチド

製品名

由来

適用・アプリケーション

製品番号

MDM2 protein(Recombinant)(Active )HuFuncS, SDS-PAGEab188727
MDM2 protein(Recombinant)(Active )HuFuncS, SDS-PAGEab188732
MDM2 protein (Recombinant)HuSDS-PAGE, WBab167941
MDM2 protein(Recombinant)HuWBab71353
MDM2 protein(Recombinant)HuSDS-PAGEab82080
MDM2 peptideHuab48039

生理活性物質

製品名

解説

製品番号

(±)-Nutlin-3Potent, selective MDM2 antagonistab120646
(+)-Nutlin-3p53-MDM2 binding inhibitorab144426
(-)-Nutlin-3Potent p53-MDM2 binding inhibitorab144428
Caylin-1MDM2 inhibitorab144458
Lithocholic acidEndogenous MDM2 and MDM4 selective inhibitor. Detergent.ab145598
NSC 66811Potent, cell-permeable MDM2 inhibitorab142190

MDM2 について

Function
機能
E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as an ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways.
Tissue specificity
組織特異性
Ubiquitous. Isoform Mdm2-A, isoform Mdm2-B, isoform Mdm2-C, isoform Mdm2-D, isoform Mdm2-E, isoform Mdm2-F and isoform Mdm2-G are observed in a range of cancers but absent in normal tissues.
Involvement in disease
疾患関連性
Note=Seems to be amplified in certain tumors (including soft tissue sarcomas, osteosarcomas and gliomas). A higher frequency of splice variants lacking p53 binding domain sequences was found in late-stage and high-grade ovarian and bladder carcinomas. Four of the splice variants show loss of p53 binding.
Sequence similarities
配列類似性
  • Belongs to the MDM2/MDM4 family.
  • Contains 1 RanBP2-type zinc finger.
  • Contains 1 RING-type zinc finger.
  • Contains 1 SWIB domain.
Post-translational modifications
翻訳後修飾
Phosphorylated in response to ionizing radiation in an ATM-dependent manner. Auto-ubiquitinated; which leads to proteasomal degradation. Deubiquitinated by USP2 leads to its accumulation and increases deubiquitinilation and degradation of p53/TP53. Deubiquitinated by USP7; leading to stabilize it.
Cellular localization
細胞内局在性
Nucleus > nucleoplasm. Cytoplasm. Nucleus > nucleolus. Expressed predominantly in the nucleoplasm. Interaction with ARF(P14) results in the localization of both proteins to the nucleolus. The nucleolar localization signals in both ARF(P14) and MDM2 may be necessary to allow efficient nucleolar localization of both proteins. Colocalizes with RASSF1 isoform A in the nucleus.

関連リンク


Cancer
ポータル

注目ターゲット

p53 ~ 注目ターゲット
のおすすめ製品

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