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MEK ~ 注目ターゲットのおすすめ製品

ウサギ・モノクローナル 抗体

ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

MEK1 Ms, Rat, Cow, Hu, DogFlow Cyt, ICC/IF, IHC-Fr, IHC-P, IP, WB85 ab32091
MEK1 HuFlow Cyt, ICC, IP, WB6 ab32576
MEK1 (pS298) Hu, Ms, RatICC/IF, IHC-Fr, WB76 ab96379
MEK1
Alexa Fluor® 647
HuICC/IF, Flow Cyt ab193986
MEK2 Hu, MsFlow Cyt, ICC/IF, IHC-P, IP, WB53 ab32517
MEK2
Alexa Fluor® 488
HuFlow Cyt, ICC/IF ab200606
MEK2
Alexa Fluor® 647
HuICC/IF ab200519
MEKK2 Ms, Rat, HuFlow Cyt, ICC, IHC-Fr, IHC-P, IP, WB52 ab33918
MEK3 Hu, Ms, RatICC/IF, IHC-P, IP, WB ab195037
MEK3 HuFlow Cyt, IP, WB ab40836
MEK4 Hu, Ms, RatFlow Cyt, WB31 ab33912
MEK4
Alexa Fluor® 488
HuICC/IF ab200611
MEK6 Hu, Ms, RatIP, WB ab33866
MEK7 Hu, Ms, RatFlow Cyt, ICC, IHC-P, IP, WB5 ab52618

抗体

ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

MEK1Rb-PHu, RatICC, IHC-P, WB1 ab109556
MEK2Ms-M
HuWB ab70590
MEK2 (pT394)Rb-PHu, Ms, RatELISA, ICC/IF, IHC-P, IP, WB1 ab30622
MEK3Rb-PHu, MsELISA, IHC-P, WB1 ab5428
MEK5Rb-PHu, Ms, Rat, Dog, Mk, Rb, Shp, XlELISA, IP, WB ab69537
MEK6Rb-PHuICC/IF, IHC-P, WB ab154901
抗体一覧

タンパク質・ペプチド

製品名

由来

適用・アプリケーション

製品番号

MEK1 full length protein (Recombinant)HuFuncS, SDS-PAGEab63209
MEK2 full length protein(Recombinant)HuFuncS, SDS-PAGEab60013
MEK2 full length protein(Recombinant)HuMS, SDS-PAGEab124543
MEK5 full length protein(Recombinant)HuELISA, SDS-PAGE, WBab114459
MEK6 full length protein(Recombinant)HuELISA, SDS-PAGE, WBab132402
MEK6 protein fragment(Recombinant)HuFuncS, SDS-PAGEab95252
タンパク質・ペプチド一覧

生理活性物質

製品名

解説

製品番号

(-)-Schisandrin BAnti-inflammatory and antioxidant agentab143549
PD 98059MEK1 inhibitorab120234
SL 327MEK inhibitorab120082
Hymenialdisine analogue 1Non-specific kinase inhibitor including MEK-1, GSK-3Β, and CKIab143825
生理活性物質一覧

キット

製品名

交差種

容量

製品番号

Mek1 ELISA KitHu, Ms, Rat1x96testsab208988
Mek3 ELISA KitHu, Ms, Rat1x96testsab217775
Mek1 (pS217/221) ELISA KitHu, Ms, Rat1x96testsab126446
Mek1 (pS217/221) + total Mek1 ELISA KitHu, Ms, Rat1x96testsab126448

MEK について

MEK1
Function
機能
Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates ERK1 and ERK2 MAP kinases.
Tissue specificity
組織特異性
Widely expressed, with extremely low levels in brain.
Involvement in disease
疾患関連性
Defects in MAP2K1 are a cause of cardiofaciocutaneous syndrome
Sequence similarities
配列類似性
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.Contains 1 protein kinase domain.
Post-translational modifications
翻訳後修飾
Phosphorylation on Ser/Thr by MAP kinase kinase kinases (RAF or MEKK1) regulates positively the kinase activity. Acetylation by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway.
MEK2
Function
機能
Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases
Involvement in disease
疾患関連性
Defects in MAP2K2 are a cause of cardiofaciocutaneous syndrome
Sequence similarities
配列類似性
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.Contains 1 protein kinase domain.
Post-translational modifications
翻訳後修飾
MAPKK is itself dependent on Ser/Thr phosphorylation for activity catalyzed by MAP kinase kinase kinases (RAF or MEKK1). Acetylation of Ser-222 and Ser-226 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway.
MEK3
Function
機能
Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38.
Tissue specificity
組織特異性
Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.
Involvement in disease
疾患関連性
Note=Defects in MAP2K3 may be involved in colon cancer.
Sequence similarities
配列類似性
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.Contains 1 protein kinase domain.
Post-translational modifications
翻訳後修飾
Autophosphorylated. Phosphorylation on Ser-218 and Thr-222 by MAP kinase kinase kinases regulates positively the kinase activity. Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.
MEK4
Function
機能
Dual specificity kinase that activates the JUN kinases MAPK8 (JNK1) and MAPK9 (JNK2) as well as MAPK14 (p38) but not MAPK1 (ERK2) or MAPK3 (ERK1).
Tissue specificity
組織特異性
Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.
Sequence similarities
配列類似性
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.Contains 1 protein kinase domain.
Post-translational modifications
翻訳後修飾
Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases.
MEK5
Function
機能
Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appear to play a critical role in protecting cells from stress-induced apopotosis, neuronal survival and cardiac development and angiogenesis.
Tissue specificity
組織特異性
Expressed in many adult tissues. Abundant in heart and skeletal muscle.
Sequence similarities
配列類似性
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.Contains 1 OPR domain.Contains 1 protein kinase domain.
Post-translational modifications
翻訳後修飾
Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases. Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.
MEK6
Function
機能
Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appear to play a critical role in protecting cells from stress-induced apopotosis, neuronal survival and cardiac development and angiogenesis.
Tissue specificity
組織特異性
Expressed in many adult tissues. Abundant in heart and skeletal muscle.
Sequence similarities
配列類似性
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.Contains 1 OPR domain.Contains 1 protein kinase domain.
Post-translational modifications
翻訳後修飾
Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases. Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.
MEK7
Function
機能
Stress activated, dual specificity kinase that activates the JUN kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3.
Tissue specificity
組織特異性
Ubiquitous; with highest level of expression in skeletal muscle. Isoform 3 is found at low levels in placenta, fetal liver, and skeletal muscle.
Sequence similarities
配列類似性
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.Contains 1 protein kinase domain.
Post-translational modifications
翻訳後修飾
Activated by phosphorylation on Ser/Thr.
Cellular localization
細胞内局在性
Nucleus. Cytoplasm.

関連リンク


注目のターゲット

ERK1/2 signaling in cancer

MAPK-ERK1/2 interactive pathway

MAPK-JNK interactive pathway

MAPK-p38 signaling interactive pathway

Alexa Fluor® is a registered trademark of Life Technologies. Alexa Fluor® dye conjugates contain(s) technology licensed to Abcam by Life Technologies.


ウサギ・モノクローナル 抗体

ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

MEK1 Ms, Rat, Cow, Hu, DogFlow Cyt, ICC/IF, IHC-Fr, IHC-P, IP, WB85 ab32091
MEK1 HuFlow Cyt, ICC, IP, WB6 ab32576
MEK1 (pS298) Hu, Ms, RatICC/IF, IHC-Fr, WB76 ab96379
MEK1
Alexa Fluor® 647
HuICC/IF, Flow Cyt ab193986
MEK2 Hu, MsFlow Cyt, ICC/IF, IHC-P, IP, WB53 ab32517
MEK2
Alexa Fluor® 488
HuFlow Cyt, ICC/IF ab200606
MEK2
Alexa Fluor® 647
HuICC/IF ab200519
MEKK2 Ms, Rat, HuFlow Cyt, ICC, IHC-Fr, IHC-P, IP, WB52 ab33918
MEK3 Hu, Ms, RatICC/IF, IHC-P, IP, WB ab195037
MEK3 HuFlow Cyt, IP, WB ab40836
MEK4 Hu, Ms, RatFlow Cyt, WB31 ab33912
MEK4
Alexa Fluor® 488
HuICC/IF ab200611
MEK6 Hu, Ms, RatIP, WB ab33866
MEK7 Hu, Ms, RatFlow Cyt, ICC, IHC-P, IP, WB5 ab52618

抗体

ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

MEK1Rb-PHu, RatICC, IHC-P, WB1 ab109556
MEK2Ms-M
HuWB ab70590
MEK2 (pT394)Rb-PHu, Ms, RatELISA, ICC/IF, IHC-P, IP, WB1 ab30622
MEK3Rb-PHu, MsELISA, IHC-P, WB1 ab5428
MEK5Rb-PHu, Ms, Rat, Dog, Mk, Rb, Shp, XlELISA, IP, WB ab69537
MEK6Rb-PHuICC/IF, IHC-P, WB ab154901
抗体一覧

タンパク質・ペプチド

製品名

由来

適用・アプリケーション

製品番号

MEK1 full length protein (Recombinant)HuFuncS, SDS-PAGEab63209
MEK2 full length protein(Recombinant)HuFuncS, SDS-PAGEab60013
MEK2 full length protein(Recombinant)HuMS, SDS-PAGEab124543
MEK5 full length protein(Recombinant)HuELISA, SDS-PAGE, WBab114459
MEK6 full length protein(Recombinant)HuELISA, SDS-PAGE, WBab132402
MEK6 protein fragment(Recombinant)HuFuncS, SDS-PAGEab95252
タンパク質・ペプチド一覧

生理活性物質

製品名

解説

製品番号

(-)-Schisandrin BAnti-inflammatory and antioxidant agentab143549
PD 98059MEK1 inhibitorab120234
SL 327MEK inhibitorab120082
Hymenialdisine analogue 1Non-specific kinase inhibitor including MEK-1, GSK-3Β, and CKIab143825
生理活性物質一覧

キット

製品名

交差種

容量

製品番号

Mek1 ELISA KitHu, Ms, Rat1x96testsab208988
Mek3 ELISA KitHu, Ms, Rat1x96testsab217775
Mek1 (pS217/221) ELISA KitHu, Ms, Rat1x96testsab126446
Mek1 (pS217/221) + total Mek1 ELISA KitHu, Ms, Rat1x96testsab126448

MEK について

MEK1
Function
機能
Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates ERK1 and ERK2 MAP kinases.
Tissue specificity
組織特異性
Widely expressed, with extremely low levels in brain.
Involvement in disease
疾患関連性
Defects in MAP2K1 are a cause of cardiofaciocutaneous syndrome
Sequence similarities
配列類似性
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.Contains 1 protein kinase domain.
Post-translational modifications
翻訳後修飾
Phosphorylation on Ser/Thr by MAP kinase kinase kinases (RAF or MEKK1) regulates positively the kinase activity. Acetylation by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway.
MEK2
Function
機能
Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases
Involvement in disease
疾患関連性
Defects in MAP2K2 are a cause of cardiofaciocutaneous syndrome
Sequence similarities
配列類似性
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.Contains 1 protein kinase domain.
Post-translational modifications
翻訳後修飾
MAPKK is itself dependent on Ser/Thr phosphorylation for activity catalyzed by MAP kinase kinase kinases (RAF or MEKK1). Acetylation of Ser-222 and Ser-226 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway.
MEK3
Function
機能
Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38.
Tissue specificity
組織特異性
Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.
Involvement in disease
疾患関連性
Note=Defects in MAP2K3 may be involved in colon cancer.
Sequence similarities
配列類似性
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.Contains 1 protein kinase domain.
Post-translational modifications
翻訳後修飾
Autophosphorylated. Phosphorylation on Ser-218 and Thr-222 by MAP kinase kinase kinases regulates positively the kinase activity. Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.
MEK4
Function
機能
Dual specificity kinase that activates the JUN kinases MAPK8 (JNK1) and MAPK9 (JNK2) as well as MAPK14 (p38) but not MAPK1 (ERK2) or MAPK3 (ERK1).
Tissue specificity
組織特異性
Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.
Sequence similarities
配列類似性
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.Contains 1 protein kinase domain.
Post-translational modifications
翻訳後修飾
Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases.
MEK5
Function
機能
Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appear to play a critical role in protecting cells from stress-induced apopotosis, neuronal survival and cardiac development and angiogenesis.
Tissue specificity
組織特異性
Expressed in many adult tissues. Abundant in heart and skeletal muscle.
Sequence similarities
配列類似性
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.Contains 1 OPR domain.Contains 1 protein kinase domain.
Post-translational modifications
翻訳後修飾
Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases. Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.
MEK6
Function
機能
Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appear to play a critical role in protecting cells from stress-induced apopotosis, neuronal survival and cardiac development and angiogenesis.
Tissue specificity
組織特異性
Expressed in many adult tissues. Abundant in heart and skeletal muscle.
Sequence similarities
配列類似性
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.Contains 1 OPR domain.Contains 1 protein kinase domain.
Post-translational modifications
翻訳後修飾
Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases. Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.
MEK7
Function
機能
Stress activated, dual specificity kinase that activates the JUN kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3.
Tissue specificity
組織特異性
Ubiquitous; with highest level of expression in skeletal muscle. Isoform 3 is found at low levels in placenta, fetal liver, and skeletal muscle.
Sequence similarities
配列類似性
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.Contains 1 protein kinase domain.
Post-translational modifications
翻訳後修飾
Activated by phosphorylation on Ser/Thr.
Cellular localization
細胞内局在性
Nucleus. Cytoplasm.

関連リンク


注目のターゲット

ERK1/2 signaling in cancer

MAPK-ERK1/2 interactive pathway

MAPK-JNK interactive pathway

MAPK-p38 signaling interactive pathway

Alexa Fluor® is a registered trademark of Life Technologies. Alexa Fluor® dye conjugates contain(s) technology licensed to Abcam by Life Technologies.


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