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PPAR ～ 注目ターゲットのおすすめ製品
ウサギ・モノクローナル 抗体 |  |
ターゲット名 | 交差種 | 適用・アプリケーション | 文献 数 |
| ||||
|---|---|---|---|---|---|---|---|---|
| PPAR alpha + PPAR beta/delta | Hu, Ms, Rat | WB | ab178865 | |||||
| PPAR delta | Hu | WB | ab173299 |  | ||||
| PPAR delta | Hu, Ms, Rat | WB, IP | 1 | ab178866 | ||||
| Hu, Ms, Rat | WB | 6 | ab191407 | | ||||
抗体
ターゲット名 | 交差種 | 適用・アプリケーション | 文献 数 |
| ||||
|---|---|---|---|---|---|---|---|---|
| ELISA, ICC/IF, IHC-FoFr, IHC-Fr, IHC-P, WB | 53 | 13 | ab8934 | |||||
| PPAR alpha | Ms, Rat, Hu | IP, WB | 16 | 4 | ab24509 | |||
| Ms, Rat, Hu | GSA, ICC/IF, WB | 6 | 2 | ab3484 | ||||
| PPAR gamma | Hu, Ms | ELISA, ICC/IF, IHC-P | 5 | 1 | ab59256 | |||
| PPAR delta | Hu, Ms | ICC/IF, WB | 9 | 3 | ab8937 | |||
| PPAR delta | Hu, Ms, Rat | ELISA, WB | 4 | 1 | ab21209 | |||
| PPAR delta | Hu, Ms, Rat, Pig, Shp | ICC/IF, IHC-FoFr, IHC-Fr, IHC-P, WB | 16 | 9 | ab23673 | |||
| 抗体一覧 | ||||||||
タンパク質・ペプチド
製品名 | 製品番号 | ||
|---|---|---|---|
| PPAR alpha protein （Recombinant） | Hu | GSA, Other, SDS-PAGE | ab81927 |
| PPAR alpha protein（Recombinant） | Hu | GSA | ab81926 |
| PPAR alpha protein （Recombinant） | Hu | SDS-PAGE | ab82045 |
| PPAR delta protein（Recombinant） | Hu | GSA, Other, SDS-PAGE | ab82051 |
| PPAR delta protein （Recombinant） | Hu | SDS-PAGE | ab82033 |
| PPAR gamma protein（Recombinant） | Hu | ELISA, Inhib, WB | ab83647 |
| PPAR gamma protein（Recombinant） | SDS-PAGE | ab53382 | |
| タンパク質・ペプチド一覧 | |||
生理活性物質
製品名 | 解説 | 製品番号 | |
|---|---|---|---|
| Hesperetin | Apoptotic and anti-inflammatory agent. PPARγ inducer. | ab142887 |  |
| Rosiglitazone | Selective PPARγ agonist | ab120762 |  |
| Auraptene | Activates PPARα and PPARγ. Modulates estrogen receptors. | ab141907 |  |
| Astaxanthin | Potent antioxidant agent. PPARα agonist and PPARγ antagonist. | ab144193 |  |
| FH-535 | Wnt/β-cantenin inhibitor and PPARγ and PPARδ antagonist. | ab144594 |  |
| 2,4-Thiazolidinedione | PPARγ agonist. Insulin sensitizing agent. | ab144811 |  |
| GSK-3787 | Potent, selective, irreversible PPARδ antagonist. | ab144575 |  |
| Bezafibrate | Pan-PPAR agonist. | ab141233 |  |
| 生理活性物質一覧 | |||
キット
製品名 | 交差種 | 容量 | 製品番号 |
|---|---|---|---|
| PPAR gamma Transcription Factor Assay Kit | Hu, Ms, Rat | 96test | ab133101 |
| PPAR delta Transcription Factor Assay Kit | Hu, Ms | 96test | ab133106 |
| PPAR alpha Transcription Factor Assay Kit | Hu, Ms, Rat | 96test | ab133107 |
| PPAR (alpha, delta, gamma) Transcription Factor Assay Kit | 96test | ab133113 |
PPAR について
| PPAR alpha | ||
|---|---|---|
| Function 機能 | Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. | |
組織特異性 | Skeletal muscle, liver, heart and kidney. | |
配列類似性 |
| |
細胞内局在性 | Nucleus. | |
| PPAR gamma | ||
| Function 機能 | Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. | |
組織特異性 | Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also detectable in placenta, lung and ovary. | |
疾患関連性 | Defects in PPARG can lead to type 2 insulin-resistant diabetes and hyptertension. PPARG mutations may be associated with colon cancer. | |
配列類似性 |
| |
細胞内局在性 | Nucleus. | |
| PPAR delta | ||
| Function 機能 | Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand. | |
組織特異性 | Ubiquitous with maximal levels in placenta and skeletal muscle. | |
配列類似性 |
| |
細胞内局在性 | Nucleus. | |
関連リンク
 注目ターゲット |  注目ターゲット Insulin |
ウサギ・モノクローナル 抗体 | |
ターゲット名 | 交差種 | 適用・アプリケーション | 文献 数 |
| ||||
|---|---|---|---|---|---|---|---|---|
| PPAR alpha + PPAR beta/delta | Hu, Ms, Rat | WB | ab178865 | |||||
| PPAR delta | Hu | WB | ab173299 | | ||||
| PPAR delta | Hu, Ms, Rat | WB, IP | 1 | ab178866 | ||||
| Hu, Ms, Rat | WB | 6 | ab191407 | | ||||
抗体
ターゲット名 | 交差種 | 適用・アプリケーション | 文献 数 |
| ||||
|---|---|---|---|---|---|---|---|---|
| ELISA, ICC/IF, IHC-FoFr, IHC-Fr, IHC-P, WB | 53 | 13 | ab8934 | |||||
| PPAR alpha | Ms, Rat, Hu | IP, WB | 16 | 4 | ab24509 | |||
| Ms, Rat, Hu | GSA, ICC/IF, WB | 6 | 2 | ab3484 | ||||
| PPAR gamma | Hu, Ms | ELISA, ICC/IF, IHC-P | 5 | 1 | ab59256 | |||
| PPAR delta | Hu, Ms | ICC/IF, WB | 9 | 3 | ab8937 | |||
| PPAR delta | Hu, Ms, Rat | ELISA, WB | 4 | 1 | ab21209 | |||
| PPAR delta | Hu, Ms, Rat, Pig, Shp | ICC/IF, IHC-FoFr, IHC-Fr, IHC-P, WB | 16 | 9 | ab23673 | |||
| 抗体一覧 | ||||||||
タンパク質・ペプチド
製品名 | 製品番号 | ||
|---|---|---|---|
| PPAR alpha protein （Recombinant） | Hu | GSA, Other, SDS-PAGE | ab81927 |
| PPAR alpha protein（Recombinant） | Hu | GSA | ab81926 |
| PPAR alpha protein （Recombinant） | Hu | SDS-PAGE | ab82045 |
| PPAR delta protein（Recombinant） | Hu | GSA, Other, SDS-PAGE | ab82051 |
| PPAR delta protein （Recombinant） | Hu | SDS-PAGE | ab82033 |
| PPAR gamma protein（Recombinant） | Hu | ELISA, Inhib, WB | ab83647 |
| PPAR gamma protein（Recombinant） | SDS-PAGE | ab53382 | |
| タンパク質・ペプチド一覧 | |||
生理活性物質
製品名 | 解説 | 製品番号 | |
|---|---|---|---|
| Hesperetin | Apoptotic and anti-inflammatory agent. PPARγ inducer. | ab142887 | |
| Rosiglitazone | Selective PPARγ agonist | ab120762 | |
| Auraptene | Activates PPARα and PPARγ. Modulates estrogen receptors. | ab141907 | |
| Astaxanthin | Potent antioxidant agent. PPARα agonist and PPARγ antagonist. | ab144193 | |
| FH-535 | Wnt/β-cantenin inhibitor and PPARγ and PPARδ antagonist. | ab144594 | |
| 2,4-Thiazolidinedione | PPARγ agonist. Insulin sensitizing agent. | ab144811 | |
| GSK-3787 | Potent, selective, irreversible PPARδ antagonist. | ab144575 | |
| Bezafibrate | Pan-PPAR agonist. | ab141233 | |
| 生理活性物質一覧 | |||
キット
製品名 | 交差種 | 容量 | 製品番号 |
|---|---|---|---|
| PPAR gamma Transcription Factor Assay Kit | Hu, Ms, Rat | 96test | ab133101 |
| PPAR delta Transcription Factor Assay Kit | Hu, Ms | 96test | ab133106 |
| PPAR alpha Transcription Factor Assay Kit | Hu, Ms, Rat | 96test | ab133107 |
| PPAR (alpha, delta, gamma) Transcription Factor Assay Kit | 96test | ab133113 |
PPAR について
| PPAR alpha | ||
|---|---|---|
| Function 機能 | Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. | |
組織特異性 | Skeletal muscle, liver, heart and kidney. | |
配列類似性 |
| |
細胞内局在性 | Nucleus. | |
| PPAR gamma | ||
| Function 機能 | Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. | |
組織特異性 | Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also detectable in placenta, lung and ovary. | |
疾患関連性 | Defects in PPARG can lead to type 2 insulin-resistant diabetes and hyptertension. PPARG mutations may be associated with colon cancer. | |
配列類似性 |
| |
細胞内局在性 | Nucleus. | |
| PPAR delta | ||
| Function 機能 | Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand. | |
組織特異性 | Ubiquitous with maximal levels in placenta and skeletal muscle. | |
配列類似性 |
| |
細胞内局在性 | Nucleus. | |
関連リンク
注目ターゲット | 注目ターゲット Insulin |
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