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PPAR ~ 注目ターゲットのおすすめ製品


ウサギ・モノクローナル 抗体

ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

PPAR alpha + PPAR beta/delta Hu, Ms, RatWB ab178865
PPAR delta HuWB ab173299
PPAR delta Hu, Ms, RatWB, IP1 ab178866
PPAR gamma Hu, Ms, RatWB6 ab191407

抗体

ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

PPAR alphaRb-P Ms, Rat, HuELISA, ICC/IF, IHC-FoFr, IHC-Fr, IHC-P, WB5313 ab8934
PPAR alphaRb-P Ms, Rat, HuIP, WB164 ab24509
PPAR alpha (pS12)Rb-P Ms, Rat, HuGSA, ICC/IF, WB62 ab3484
PPAR gamma Rb-PHu, MsELISA, ICC/IF, IHC-P51 ab59256
PPAR deltaRb-PHu, MsICC/IF, WB93 ab8937
PPAR delta Goat-PHu, Ms, RatELISA, WB41 ab21209
PPAR delta Rb-PHu, Ms, Rat, Pig, ShpICC/IF, IHC-FoFr, IHC-Fr, IHC-P, WB169 ab23673
抗体一覧

タンパク質・ペプチド

製品名

由来

適用・アプリケーション

製品番号

PPAR alpha protein (Recombinant)HuGSA, Other, SDS-PAGEab81927
PPAR alpha protein(Recombinant)HuGSAab81926
PPAR alpha protein (Recombinant)HuSDS-PAGEab82045
PPAR delta protein(Recombinant)HuGSA, Other, SDS-PAGEab82051
PPAR delta protein (Recombinant)HuSDS-PAGEab82033
PPAR gamma protein(Recombinant)HuELISA, Inhib, WBab83647
PPAR gamma protein(Recombinant)SDS-PAGEab53382
タンパク質・ペプチド一覧

生理活性物質

製品名

解説

製品番号

HesperetinApoptotic and anti-inflammatory agent. PPARγ inducer.ab142887
RosiglitazoneSelective PPARγ agonistab120762
AurapteneActivates PPARα and PPARγ. Modulates estrogen receptors.ab141907
AstaxanthinPotent antioxidant agent. PPARα agonist and PPARγ antagonist.ab144193
FH-535Wnt/β-cantenin inhibitor and PPARγ and PPARδ antagonist.ab144594
2,4-ThiazolidinedionePPARγ agonist. Insulin sensitizing agent.ab144811
GSK-3787Potent, selective, irreversible PPARδ antagonist.ab144575
BezafibratePan-PPAR agonist.ab141233
生理活性物質一覧
 

キット

製品名

交差種

容量

製品番号

PPAR gamma Transcription Factor Assay KitHu, Ms, Rat96testab133101
PPAR delta Transcription Factor Assay Kit Hu, Ms96testab133106
PPAR alpha Transcription Factor Assay KitHu, Ms, Rat96testab133107
PPAR (alpha, delta, gamma) Transcription Factor Assay Kit96testab133113
 

PPAR について

PPAR alpha
Function
機能
Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2.
Tissue specificity
組織特異性
Skeletal muscle, liver, heart and kidney.
Sequence similarities
配列類似性
  • Belongs to the nuclear hormone receptor family.
  • NR1 subfamily.
  • Contains 1 nuclear receptor DNA-binding domain.
Cellular localization
細胞内局在性
Nucleus.
PPAR gamma
Function
機能
Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis.
Tissue specificity
組織特異性
Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also detectable in placenta, lung and ovary.
Involvement in disease
疾患関連性
Defects in PPARG can lead to type 2 insulin-resistant diabetes and hyptertension. PPARG mutations may be associated with colon cancer.
Sequence similarities
配列類似性
  • Belongs to the nuclear hormone receptor family.
  • NR1 subfamily.
  • Contains 1 nuclear receptor DNA-binding domain.
Cellular localization
細胞内局在性
Nucleus.
PPAR delta
Function
機能
Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.
Tissue specificity
組織特異性
Ubiquitous with maximal levels in placenta and skeletal muscle.
Sequence similarities
配列類似性
  • Belongs to the nuclear hormone receptor family.
  • NR1 subfamily.
  • Contains 1 nuclear receptor DNA-binding domain.
Cellular localization
細胞内局在性
Nucleus.

関連リンク


注目ターゲット

注目ターゲット
Insulin


ウサギ・モノクローナル 抗体

ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

PPAR alpha + PPAR beta/delta Hu, Ms, RatWB ab178865
PPAR delta HuWB ab173299
PPAR delta Hu, Ms, RatWB, IP1 ab178866
PPAR gamma Hu, Ms, RatWB6 ab191407

抗体

ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

PPAR alphaRb-P Ms, Rat, HuELISA, ICC/IF, IHC-FoFr, IHC-Fr, IHC-P, WB5313 ab8934
PPAR alphaRb-P Ms, Rat, HuIP, WB164 ab24509
PPAR alpha (pS12)Rb-P Ms, Rat, HuGSA, ICC/IF, WB62 ab3484
PPAR gamma Rb-PHu, MsELISA, ICC/IF, IHC-P51 ab59256
PPAR deltaRb-PHu, MsICC/IF, WB93 ab8937
PPAR delta Goat-PHu, Ms, RatELISA, WB41 ab21209
PPAR delta Rb-PHu, Ms, Rat, Pig, ShpICC/IF, IHC-FoFr, IHC-Fr, IHC-P, WB169 ab23673
抗体一覧

タンパク質・ペプチド

製品名

由来

適用・アプリケーション

製品番号

PPAR alpha protein (Recombinant)HuGSA, Other, SDS-PAGEab81927
PPAR alpha protein(Recombinant)HuGSAab81926
PPAR alpha protein (Recombinant)HuSDS-PAGEab82045
PPAR delta protein(Recombinant)HuGSA, Other, SDS-PAGEab82051
PPAR delta protein (Recombinant)HuSDS-PAGEab82033
PPAR gamma protein(Recombinant)HuELISA, Inhib, WBab83647
PPAR gamma protein(Recombinant)SDS-PAGEab53382
タンパク質・ペプチド一覧

生理活性物質

製品名

解説

製品番号

HesperetinApoptotic and anti-inflammatory agent. PPARγ inducer.ab142887
RosiglitazoneSelective PPARγ agonistab120762
AurapteneActivates PPARα and PPARγ. Modulates estrogen receptors.ab141907
AstaxanthinPotent antioxidant agent. PPARα agonist and PPARγ antagonist.ab144193
FH-535Wnt/β-cantenin inhibitor and PPARγ and PPARδ antagonist.ab144594
2,4-ThiazolidinedionePPARγ agonist. Insulin sensitizing agent.ab144811
GSK-3787Potent, selective, irreversible PPARδ antagonist.ab144575
BezafibratePan-PPAR agonist.ab141233
生理活性物質一覧
 

キット

製品名

交差種

容量

製品番号

PPAR gamma Transcription Factor Assay KitHu, Ms, Rat96testab133101
PPAR delta Transcription Factor Assay Kit Hu, Ms96testab133106
PPAR alpha Transcription Factor Assay KitHu, Ms, Rat96testab133107
PPAR (alpha, delta, gamma) Transcription Factor Assay Kit96testab133113
 

PPAR について

PPAR alpha
Function
機能
Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2.
Tissue specificity
組織特異性
Skeletal muscle, liver, heart and kidney.
Sequence similarities
配列類似性
  • Belongs to the nuclear hormone receptor family.
  • NR1 subfamily.
  • Contains 1 nuclear receptor DNA-binding domain.
Cellular localization
細胞内局在性
Nucleus.
PPAR gamma
Function
機能
Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis.
Tissue specificity
組織特異性
Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also detectable in placenta, lung and ovary.
Involvement in disease
疾患関連性
Defects in PPARG can lead to type 2 insulin-resistant diabetes and hyptertension. PPARG mutations may be associated with colon cancer.
Sequence similarities
配列類似性
  • Belongs to the nuclear hormone receptor family.
  • NR1 subfamily.
  • Contains 1 nuclear receptor DNA-binding domain.
Cellular localization
細胞内局在性
Nucleus.
PPAR delta
Function
機能
Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.
Tissue specificity
組織特異性
Ubiquitous with maximal levels in placenta and skeletal muscle.
Sequence similarities
配列類似性
  • Belongs to the nuclear hormone receptor family.
  • NR1 subfamily.
  • Contains 1 nuclear receptor DNA-binding domain.
Cellular localization
細胞内局在性
Nucleus.

関連リンク


注目ターゲット

注目ターゲット
Insulin

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