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Caveolin ~ 注目ターゲットのおすすめ製品


ウサギ・モノクローナル 抗体

ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

Caveolin 1 HuICC, ICC/IF, IHC-P, WB72 ab32577
Caveolin 1 Hu, MsFlow Cyt, ICC/IF, IHC-P, IP, WB ab192869
Caveolin 1
Alexa Fluor® 488
HuICC/IF ab185043
Caveolin 1
Alexa Fluor® 647
HuICC/IF ab193892
Caveolin 2 HuICC/IF, IHC-P, IP, WB ab79397
Caveolin 2Hu, Ms, RatICC/IF, WB 1 ab133484
Caveolin 3IP, WB ab171752

抗体

ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

Caveolin 1Rb-P Ms, Rat, Hm, Dog, HuICC/IF, IHC-Fr, IHC-P, IP, WB6250ab2910
Caveolin 3Rb-P Ms, Rat, Hu, ShpICC, ICC/IF, IHC-Fr, IHC-P, IP, WB3111 ab2912
Caveolin 1Rb-PHu, Ms, Rat, Dog, PigICC/IF, IHC-P, IP, WB179 ab18199
Caveolin 2
(pY19)
Rb-P Ms, Rat, HuICC, ICC/IF, IHC-P, IP, WB54 ab3417
Caveolin 3Rb-PHu, Ms, RatICC, IHC-P, IP, WB23 ab30750
Caveolin 1
(pY14)
Rb-PHu, Rat, CowELISA, ICC/IF, WB12 ab38468
Caveolin 1Ms-M Ms, Rat, Hm, Hu, PigFlow Cyt, ICC/IF, IP, WB1413 ab17052
Caveolin 2Rb-P Ms, RatICC/IF, IHC-P, IP, WB84 ab2911
抗体一覧

タンパク質・ペプチド

製品名

由来

適用・アプリケーション

製品番号

Caveolin-1 full length protein(Recombinant)HuELISA, SDS-PAGE, WBab114170
Caveolin-1 peptideMsBLab18607
Caveolin-2 full length protein(Recombinant)HuELISA, SDS-PAGE, WBab114515
Caveolin-3 protein fragment(Recombinant)HuELISA, SDS-PAGE, WBab114265
タンパク質・ペプチド一覧

Caveolin について

Caveolin 1
Function
機能
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway.
Tissue specificity
組織特異性
Expressed in muscle and lung, less so in liver, brain and kidney.
Involvement in disease
疾患関連性
Defects in CAV1 are the cause of congenital generalized lipodystrophy type 3 (CGL3) [MIM:612526]; also called Berardinelli-Seip congenital lipodystrophy type 3 (BSCL3). Congenital generalized lipodystrophies are autosomal recessive disorders characterized by a near absence of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes.
Cellular localization
細胞内局在性
Golgi apparatus membrane. Cell membrane.
Caveolin 2
Function
機能
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation.The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression.
Tissue specificity
組織特異性
Expressed in endothelial cells, smooth muscle cells, skeletal myoblasts and fibroblasts.
Post-translational modifications
翻訳後修飾
Phosphorylated on serine and tyrosine residues. CAV1 promotes phosphorylation on Ser-23 which then targets the complex to the plasma membrane, lipid rafts and caveolae. Phosphorylation on Ser-36 appears to modulate mitosis in endothelial cells (By similarity). Phosphorylation on both Tyr-19 and Tyr-27 is required for insulin-induced 'Ser-727' phosphorylation of STAT3 and its activation. Phosphorylation on Tyr-19 is required for insulin-induced phosphorylation of MAPK1 and DNA binding of STAT3. Tyrosine phosphorylation is induced by both EGF and insulin.
Cellular localization
細胞内局在性
Nucleus. Cytoplasm. Golgi apparatus membrane. Cell membrane.
Caveolin 3
Function
機能
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress.
Tissue specificity
組織特異性
Expressed predominantly in muscle.
Involvement in disease
疾患関連性
Defects in CAV3 are the cause of limb-girdle muscular dystrophy type 1C (LGMD1C) [MIM:607801]. LGMD1C is a myopathy characterized by calf hypertrophy and mild to moderate proximal muscle weakness. LGMD1C inheritance can be autosomal dominant or recessive. Defects in CAV3 are a cause of hyperCKmia (HYPCK) [MIM:123320]. It is a disease characterized by persistent elevated levels of serum creatine kinase without muscle weakness. Defects in CAV3 are a cause of rippling muscle disease (RMD) [MIM:606072]. RMD is a rare disorder characterized by mechanically triggered contractions of skeletal muscle. In RMD, mechanical stimulation leads to electrically silent muscle contractions that spread to neighboring fibers that cause visible ripples to move over the muscle. Defects in CAV3 are a cause of cardiomyopathy familial hypertrophic (CMH) [MIM:192600]; also designated FHC or HCM. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Defects in CAV3 are the cause of long QT syndrome type 9 (LQT9) [MIM:611818]. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress. They can present with a sentinel event of sudden cardiac death in infancy. Defects in CAV3 can be a cause of sudden infant death syndrome (SIDS) [MIM:272120]. SIDS is the sudden death of an infant younger than 1 year that remains unexplained after a thorough case investigation, including performance of a complete autopsy, examination of the death scene, and review of clinical history. Pathophysiologic mechanisms for SIDS may include respiratory dysfunction, cardiac dysrhythmias, cardiorespiratory instability, and inborn errors of metabolism, but definitive pathogenic mechanisms precipitating an infant sudden death remain elusive. Long QT syndromes-associated mutations can be responsible for some SIDS cases.
Cellular localization
細胞内局在性
Golgi apparatus membrane. Cell membrane.

関連リンク


注目ターゲット

Alexa Fluor® is a registered trademark of Life Technologies. Alexa Fluor® dye conjugates contain(s) technology licensed to Abcam by Life Technologies.



ウサギ・モノクローナル 抗体

ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

Caveolin 1 HuICC, ICC/IF, IHC-P, WB72 ab32577
Caveolin 1 Hu, MsFlow Cyt, ICC/IF, IHC-P, IP, WB ab192869
Caveolin 1
Alexa Fluor® 488
HuICC/IF ab185043
Caveolin 1
Alexa Fluor® 647
HuICC/IF ab193892
Caveolin 2 HuICC/IF, IHC-P, IP, WB ab79397
Caveolin 2Hu, Ms, RatICC/IF, WB 1 ab133484
Caveolin 3IP, WB ab171752

抗体

ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

Caveolin 1Rb-P Ms, Rat, Hm, Dog, HuICC/IF, IHC-Fr, IHC-P, IP, WB6250ab2910
Caveolin 3Rb-P Ms, Rat, Hu, ShpICC, ICC/IF, IHC-Fr, IHC-P, IP, WB3111 ab2912
Caveolin 1Rb-PHu, Ms, Rat, Dog, PigICC/IF, IHC-P, IP, WB179 ab18199
Caveolin 2
(pY19)
Rb-P Ms, Rat, HuICC, ICC/IF, IHC-P, IP, WB54 ab3417
Caveolin 3Rb-PHu, Ms, RatICC, IHC-P, IP, WB23 ab30750
Caveolin 1
(pY14)
Rb-PHu, Rat, CowELISA, ICC/IF, WB12 ab38468
Caveolin 1Ms-M Ms, Rat, Hm, Hu, PigFlow Cyt, ICC/IF, IP, WB1413 ab17052
Caveolin 2Rb-P Ms, RatICC/IF, IHC-P, IP, WB84 ab2911
抗体一覧

タンパク質・ペプチド

製品名

由来

適用・アプリケーション

製品番号

Caveolin-1 full length protein(Recombinant)HuELISA, SDS-PAGE, WBab114170
Caveolin-1 peptideMsBLab18607
Caveolin-2 full length protein(Recombinant)HuELISA, SDS-PAGE, WBab114515
Caveolin-3 protein fragment(Recombinant)HuELISA, SDS-PAGE, WBab114265
タンパク質・ペプチド一覧

Caveolin について

Caveolin 1
Function
機能
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway.
Tissue specificity
組織特異性
Expressed in muscle and lung, less so in liver, brain and kidney.
Involvement in disease
疾患関連性
Defects in CAV1 are the cause of congenital generalized lipodystrophy type 3 (CGL3) [MIM:612526]; also called Berardinelli-Seip congenital lipodystrophy type 3 (BSCL3). Congenital generalized lipodystrophies are autosomal recessive disorders characterized by a near absence of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes.
Cellular localization
細胞内局在性
Golgi apparatus membrane. Cell membrane.
Caveolin 2
Function
機能
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation.The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression.
Tissue specificity
組織特異性
Expressed in endothelial cells, smooth muscle cells, skeletal myoblasts and fibroblasts.
Post-translational modifications
翻訳後修飾
Phosphorylated on serine and tyrosine residues. CAV1 promotes phosphorylation on Ser-23 which then targets the complex to the plasma membrane, lipid rafts and caveolae. Phosphorylation on Ser-36 appears to modulate mitosis in endothelial cells (By similarity). Phosphorylation on both Tyr-19 and Tyr-27 is required for insulin-induced 'Ser-727' phosphorylation of STAT3 and its activation. Phosphorylation on Tyr-19 is required for insulin-induced phosphorylation of MAPK1 and DNA binding of STAT3. Tyrosine phosphorylation is induced by both EGF and insulin.
Cellular localization
細胞内局在性
Nucleus. Cytoplasm. Golgi apparatus membrane. Cell membrane.
Caveolin 3
Function
機能
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress.
Tissue specificity
組織特異性
Expressed predominantly in muscle.
Involvement in disease
疾患関連性
Defects in CAV3 are the cause of limb-girdle muscular dystrophy type 1C (LGMD1C) [MIM:607801]. LGMD1C is a myopathy characterized by calf hypertrophy and mild to moderate proximal muscle weakness. LGMD1C inheritance can be autosomal dominant or recessive. Defects in CAV3 are a cause of hyperCKmia (HYPCK) [MIM:123320]. It is a disease characterized by persistent elevated levels of serum creatine kinase without muscle weakness. Defects in CAV3 are a cause of rippling muscle disease (RMD) [MIM:606072]. RMD is a rare disorder characterized by mechanically triggered contractions of skeletal muscle. In RMD, mechanical stimulation leads to electrically silent muscle contractions that spread to neighboring fibers that cause visible ripples to move over the muscle. Defects in CAV3 are a cause of cardiomyopathy familial hypertrophic (CMH) [MIM:192600]; also designated FHC or HCM. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Defects in CAV3 are the cause of long QT syndrome type 9 (LQT9) [MIM:611818]. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress. They can present with a sentinel event of sudden cardiac death in infancy. Defects in CAV3 can be a cause of sudden infant death syndrome (SIDS) [MIM:272120]. SIDS is the sudden death of an infant younger than 1 year that remains unexplained after a thorough case investigation, including performance of a complete autopsy, examination of the death scene, and review of clinical history. Pathophysiologic mechanisms for SIDS may include respiratory dysfunction, cardiac dysrhythmias, cardiorespiratory instability, and inborn errors of metabolism, but definitive pathogenic mechanisms precipitating an infant sudden death remain elusive. Long QT syndromes-associated mutations can be responsible for some SIDS cases.
Cellular localization
細胞内局在性
Golgi apparatus membrane. Cell membrane.

関連リンク


注目ターゲット

Alexa Fluor® is a registered trademark of Life Technologies. Alexa Fluor® dye conjugates contain(s) technology licensed to Abcam by Life Technologies.


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