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EGF/EGFR ~ 注目ターゲットのおすすめ製品


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数 評価

製品番号

EGF HuIP, WB ab206106
EGFRHu, Ms, RatFlow Cyt, ICC/IF, IHC-P, IP, WB5010ab52894
EGFR HuICC/IF, IHC-P, IP, WB3 ab32562
EGFR Hu, Ms, RatFlow Cyt, ICC, IP, WB4 3ab32077
EGFR (pY1068) HuFlow Cyt, ICC/IF, IP, WB5 ab32430
EGFR (pY1086) HuICC, IP, WB15 ab32086
EGFR (pY1092)Hu, MsICC/IF, IHC-FoFr, IHC-P, WB389ab40815
EGFR (pY1173) HuICC, IHC-P, IP, WB14 ab32578

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数 評価

製品番号

EGFMs-MHuICC/IF, sELISA, WB ab155576
EGFRb-PIHC-P, WB1 ab171327
EGFRb-PHu, MsELISA, IHC-P, Neut, sELISA, WB93 ab9695
EGFMs-MHuDot, ELISA, IHC-Fr, IHC-P, RIA11 ab10409
EGFRb-PRatI-ELISA, ICC/IF, IHC-P, Neut, sELISA, WB3 ab77851
EGFGoat-PMsELISA, sELISA, WB ab83520
EGFRb-PHuELISA, I-ELISA, WB ab94898
EGFRRat-MHu, MsELISA, Flow Cyt, ICC, IHC-Fr, Inhib, IP145ab231
EGFRMs-MHu, Ms, HrsFlow Cyt, ICC/IF, IHC - Wmt, IHC-Fr, IP103 ab30
EGFRMs-MHuFlow Cyt, IHC-Fr42 ab24293
EGFRRat-MHu, MsFlow Cyt51 ab11400
EGFRRb-P HuICC/IF, IHC-P, WB2 ab131498
EGFR (pY1068)Rb-PHu, RatWB125 ab5644
EGFR (pY1173)Rb-PHu, Ms, Rat, ChkICC/IF, WB41 ab5652
EGFR (pY1086) Rb-PHu, Ms, RatWB71 ab5650
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製品番号

EGFR prylation Human Membrane Antibody Array (17 Targets)
Targets: EGFR (Tyr845), EGFR (Tyr992), EGFR (Tyr1045), EGFR (Tyr1068), EGFR (Tyr1086), EGFR (Tyr1148), EGFR (Tyr1173), EGFR (Ser1046/1047), EGFR (Ser1070), ErbB2 (Tyr877), ErbB2 (Tyr1112), ErbB2 (Tyr 1221/1222), ErbB2 (Tyr1248), ErbB2 (Thr686), ErbB2 (Ser1113), ErbB3 (Tyr1289), ErbB4 (Tyr1284)
Hu1x2memb
1x4memb
1x8memb
ab134005
Growth Factor Human Membrane Antibody Array (41 Targets)
Targets: Amphiregulin, bFGF, EGF, EGF R, FGF-4, FGF-6, FGF-7, GCSF, GDNF, GM-CSF, HB-EGF, HGF, IGFBP-1, IGFBP-2, IGFBP-3, IGFBP-4, IGFBP-6, IGF-I, IGF-I SR, IGF-II, M-CSF, M-CSF R, beta-NGF, NT-3, NT-4, PDGF Ra, PDGF Rß, PDGF-AA, PDGF-AB, PDGF-BB, PLGF, SCF, SCF R, TGF-alpha, TGF-beta, TGF-beta2, TGF-beta3, VEGF-A, VEGF R2, VEGF R3, VEGF-D
Hu1x8memb
1x4memb
ab134002
Cytokine Human Membrane Antibody Array (60 targets)
Targets: Adiponectin, AgRP, Angiopoietin 2, Amphiregulin, Axl, bFGF, b-NGF, BTC, CCL28, CTACK, Dtk, EGFR, ENA-78, Fas, TNFRSF6, FGF-4, FGF-9, GCSF, GITR-Ligand, GITR, GRO, GRO alpha, HCC-4, HGF, ICAM-1, ICAM-3, IGFBP-3, IGFBP-6, IGF-1 sR, IL-1 R4/ST2, IL-1 RI, IL-11, IL-12 p40, IL-12 p70, IL-17, IL-2 ra, IL-6 R, IL-8, I-TAC, Lymphotactin, MIF, MIP-1 alpha, MIP-1 beta, MIP-3 beta,MSP-alpha chain, NT-4, Osteoprotegerin, Oncostatin M, PLGF, sgp130, sTNFRII, sTNFRI, TECK, TIMP-1, TIMP-2, Thrombopoietin, TRAIL R3, TRAIL R4, uPAR, VEGF-A, VEGF-D
Hu1x2memb
1x4memb
1x8memb
ab169818
アレイ製品一覧

キット

製品名

交差種

容量

製品番号

EGFR (pS1070) + total EGFR ELISA KitHu1x96testsab126435
EGFR (pY1086) ELISA KitHu1x96testsab126440
EGFR (pY992) ELISA KitHu1x96testsab126442
EGFR In-Cell ELISA KitHu1x96testsab126419
EGFR (Tyr845) In-Cell ELISA KitHu, Ms, Rat1x96testsab126421
キット一覧

タンパク質・ペプチド

製品名

由来

適用・アプリケーション

製品番号

EGFR protein (Recombinant)HuELISA, FuncS, SDS-PAGEab155639
EGFR protein (Recombinant)HuFuncS, WBab89746
EGFR protein (Recombinant)(Fc Chimera)HuELISA, FuncS, SDS-PAGEab155726
EGFR protein(Recombinant)MsELISA, FuncS, SDS-PAGEab167752
EGFR protein (Recombinant)HuSDS-PAGEab68104
EGFR protein(Recombinant)HuELISA, SDS-PAGE, WBab132920
タンパク質・ペプチド一覧

生理活性物質

製品名

解説

製品番号

AG-494Potent, selective EGF receptor tyrosine kinaseab141562
Pelitinib (EKB-569)Irreversible EGFR inhibitorab141171
Canertinib (CI-1033)Potent irreversible EGFR and HER2/ErbB2 tyrosine kinase inhibitorab141402
Erbstatin AnalogEGFR tyrosine kinase inhibitorab141549
Tyrphostin 47EGFR tyrosine kinase inhibitorab141558
生理活性物質一覧

EGFおよびEGFR について

EGF
Function
機能
EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.
Tissue specificity
組織特異性
Expressed in kidney, salivary gland, cerebrum and prostate.
Sequence similarities
配列類似性
  • Contains 9 EGF-like domains.
  • Contains 9 LDL-receptor class B repeats.
Cellular localization
細胞内局在性
Membrane.
EGFR

EGFRは分子量 170 kD の膜貫通型チロシンキナーゼ受容体である。そのリガンドである TGF-α や EGF、ARG などが EGFR の細胞外領域に結合し二量体形成を形成することで EGFR の自己リン酸化が惹起される。がん細胞の増殖、進展に関与し、非小細胞肺がんの約 62%で発現を認める。羊土社 実験医学 2013年1月号 Vol.31 No.1 特集 「がんの heterogeneity-その解明と攻略への次なる一手」 より。

Function
機能
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autoprylation on key cytoplasmic residues.
Tissue specificity
組織特異性
Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers.
Involvement in disease
疾患関連性
Defects in EGFR are associated with lung cancer (LNCR) [MIM:211980]. LNCR is a common malignancy affecting tissues of the lung.
Sequence similarities
配列類似性
Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
Post-translational modifications
翻訳後修飾
prylation at Ser-695 is partial and occurs only if Thr-693 is prylated. prylation at Thr-678 and Thr-693 by PRKD1 inhibits EGF-induced MAPK8/JNK1 activation. Deprylation by PTPRJ prevents endocytosis and stabilizes the receptor at the plasma membrane. Autoprylation at Tyr-1197 is stimulated by methylation at Arg-1199 and enhances interaction with PTPN6. Autoprylation at Tyr-1092 and/or Tyr-1110 recruits STAT3. Monoubiquitinated and polyubiquitinated upon EGF stimulation; which does not affect tyrosine kinase activity or signaling capacity but may play a role in lysosomal targeting. Polyubiquitin linkage is mainly through 'Lys-63', but linkage through 'Lys-48', 'Lys-11' and 'Lys-29' also occur. Deubiquitinated by OTUD7B, preventing degradation. Methylated. Methylation at Arg-1199 by PRMT5 positively stimulates prylation at Tyr-1197.
Cellular localization
細胞内局在
Secreted and Cell membrane. Endoplasmic reticulum membrane. Golgi apparatus membrane. Nucleus membrane. Endosome. Endosome membrane. In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER.

関連リンク


Cancer
ポータル

注目ターゲット


ウサギ・モノクローナル 抗体

ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

EGF HuIP, WB ab206106
EGFRHu, Ms, RatFlow Cyt, ICC/IF, IHC-P, IP, WB5010ab52894
EGFR HuICC/IF, IHC-P, IP, WB3 ab32562
EGFR Hu, Ms, RatFlow Cyt, ICC, IP, WB4 3ab32077
EGFR (pY1068) HuFlow Cyt, ICC/IF, IP, WB5 ab32430
EGFR (pY1086) HuICC, IP, WB15 ab32086
EGFR (pY1092)Hu, MsICC/IF, IHC-FoFr, IHC-P, WB389ab40815
EGFR (pY1173) HuICC, IHC-P, IP, WB14 ab32578

抗体

ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

EGFMs-MHuICC/IF, sELISA, WB ab155576
EGFRb-PIHC-P, WB1 ab171327
EGFRb-PHu, MsELISA, IHC-P, Neut, sELISA, WB93 ab9695
EGFMs-MHuDot, ELISA, IHC-Fr, IHC-P, RIA11 ab10409
EGFRb-PRatI-ELISA, ICC/IF, IHC-P, Neut, sELISA, WB3 ab77851
EGFGoat-PMsELISA, sELISA, WB ab83520
EGFRb-PHuELISA, I-ELISA, WB ab94898
EGFRRat-MHu, MsELISA, Flow Cyt, ICC, IHC-Fr, Inhib, IP145ab231
EGFRMs-MHu, Ms, HrsFlow Cyt, ICC/IF, IHC - Wmt, IHC-Fr, IP103 ab30
EGFRMs-MHuFlow Cyt, IHC-Fr42 ab24293
EGFRRat-MHu, MsFlow Cyt51 ab11400
EGFRRb-P HuICC/IF, IHC-P, WB2 ab131498
EGFR (pY1068)Rb-PHu, RatWB125 ab5644
EGFR (pY1173)Rb-PHu, Ms, Rat, ChkICC/IF, WB41 ab5652
EGFR (pY1086) Rb-PHu, Ms, RatWB71 ab5650
抗体一覧

抗体アレイ

製品名

交差種

容量

製品番号

EGFR prylation Human Membrane Antibody Array (17 Targets)
Targets: EGFR (Tyr845), EGFR (Tyr992), EGFR (Tyr1045), EGFR (Tyr1068), EGFR (Tyr1086), EGFR (Tyr1148), EGFR (Tyr1173), EGFR (Ser1046/1047), EGFR (Ser1070), ErbB2 (Tyr877), ErbB2 (Tyr1112), ErbB2 (Tyr 1221/1222), ErbB2 (Tyr1248), ErbB2 (Thr686), ErbB2 (Ser1113), ErbB3 (Tyr1289), ErbB4 (Tyr1284)
Hu1x2memb
1x4memb
1x8memb
ab134005
Growth Factor Human Membrane Antibody Array (41 Targets)
Targets: Amphiregulin, bFGF, EGF, EGF R, FGF-4, FGF-6, FGF-7, GCSF, GDNF, GM-CSF, HB-EGF, HGF, IGFBP-1, IGFBP-2, IGFBP-3, IGFBP-4, IGFBP-6, IGF-I, IGF-I SR, IGF-II, M-CSF, M-CSF R, beta-NGF, NT-3, NT-4, PDGF Ra, PDGF Rß, PDGF-AA, PDGF-AB, PDGF-BB, PLGF, SCF, SCF R, TGF-alpha, TGF-beta, TGF-beta2, TGF-beta3, VEGF-A, VEGF R2, VEGF R3, VEGF-D
Hu1x8memb
1x4memb
ab134002
Cytokine Human Membrane Antibody Array (60 targets)
Targets: Adiponectin, AgRP, Angiopoietin 2, Amphiregulin, Axl, bFGF, b-NGF, BTC, CCL28, CTACK, Dtk, EGFR, ENA-78, Fas, TNFRSF6, FGF-4, FGF-9, GCSF, GITR-Ligand, GITR, GRO, GRO alpha, HCC-4, HGF, ICAM-1, ICAM-3, IGFBP-3, IGFBP-6, IGF-1 sR, IL-1 R4/ST2, IL-1 RI, IL-11, IL-12 p40, IL-12 p70, IL-17, IL-2 ra, IL-6 R, IL-8, I-TAC, Lymphotactin, MIF, MIP-1 alpha, MIP-1 beta, MIP-3 beta,MSP-alpha chain, NT-4, Osteoprotegerin, Oncostatin M, PLGF, sgp130, sTNFRII, sTNFRI, TECK, TIMP-1, TIMP-2, Thrombopoietin, TRAIL R3, TRAIL R4, uPAR, VEGF-A, VEGF-D
Hu1x2memb
1x4memb
1x8memb
ab169818
アレイ製品一覧

キット

製品名

交差種

容量

製品番号

EGFR (pS1070) + total EGFR ELISA KitHu1x96testsab126435
EGFR (pY1086) ELISA KitHu1x96testsab126440
EGFR (pY992) ELISA KitHu1x96testsab126442
EGFR In-Cell ELISA KitHu1x96testsab126419
EGFR (Tyr845) In-Cell ELISA KitHu, Ms, Rat1x96testsab126421
キット一覧

タンパク質・ペプチド

製品名

由来

適用・アプリケーション

製品番号

EGFR protein (Recombinant)HuELISA, FuncS, SDS-PAGEab155639
EGFR protein (Recombinant)HuFuncS, WBab89746
EGFR protein (Recombinant)(Fc Chimera)HuELISA, FuncS, SDS-PAGEab155726
EGFR protein(Recombinant)MsELISA, FuncS, SDS-PAGEab167752
EGFR protein (Recombinant)HuSDS-PAGEab68104
EGFR protein(Recombinant)HuELISA, SDS-PAGE, WBab132920
タンパク質・ペプチド一覧

生理活性物質

製品名

解説

製品番号

AG-494Potent, selective EGF receptor tyrosine kinaseab141562
Pelitinib (EKB-569)Irreversible EGFR inhibitorab141171
Canertinib (CI-1033)Potent irreversible EGFR and HER2/ErbB2 tyrosine kinase inhibitorab141402
Erbstatin AnalogEGFR tyrosine kinase inhibitorab141549
Tyrphostin 47EGFR tyrosine kinase inhibitorab141558
生理活性物質一覧

EGFおよびEGFR について

EGF
Function
機能
EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.
Tissue specificity
組織特異性
Expressed in kidney, salivary gland, cerebrum and prostate.
Sequence similarities
配列類似性
  • Contains 9 EGF-like domains.
  • Contains 9 LDL-receptor class B repeats.
Cellular localization
細胞内局在性
Membrane.
EGFR

EGFRは分子量 170 kD の膜貫通型チロシンキナーゼ受容体である。そのリガンドである TGF-α や EGF、ARG などが EGFR の細胞外領域に結合し二量体形成を形成することで EGFR の自己リン酸化が惹起される。がん細胞の増殖、進展に関与し、非小細胞肺がんの約 62%で発現を認める。羊土社 実験医学 2013年1月号 Vol.31 No.1 特集 「がんの heterogeneity-その解明と攻略への次なる一手」 より。

Function
機能
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autoprylation on key cytoplasmic residues.
Tissue specificity
組織特異性
Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers.
Involvement in disease
疾患関連性
Defects in EGFR are associated with lung cancer (LNCR) [MIM:211980]. LNCR is a common malignancy affecting tissues of the lung.
Sequence similarities
配列類似性
Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
Post-translational modifications
翻訳後修飾
prylation at Ser-695 is partial and occurs only if Thr-693 is prylated. prylation at Thr-678 and Thr-693 by PRKD1 inhibits EGF-induced MAPK8/JNK1 activation. Deprylation by PTPRJ prevents endocytosis and stabilizes the receptor at the plasma membrane. Autoprylation at Tyr-1197 is stimulated by methylation at Arg-1199 and enhances interaction with PTPN6. Autoprylation at Tyr-1092 and/or Tyr-1110 recruits STAT3. Monoubiquitinated and polyubiquitinated upon EGF stimulation; which does not affect tyrosine kinase activity or signaling capacity but may play a role in lysosomal targeting. Polyubiquitin linkage is mainly through 'Lys-63', but linkage through 'Lys-48', 'Lys-11' and 'Lys-29' also occur. Deubiquitinated by OTUD7B, preventing degradation. Methylated. Methylation at Arg-1199 by PRMT5 positively stimulates prylation at Tyr-1197.
Cellular localization
細胞内局在
Secreted and Cell membrane. Endoplasmic reticulum membrane. Golgi apparatus membrane. Nucleus membrane. Endosome. Endosome membrane. In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER.

関連リンク


Cancer
ポータル

注目ターゲット

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