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Akt1 ~ 注目ターゲットのおすすめ製品


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Abreview
数 評価

製品番号

AKT1Hu, MsFlow Cyt, ICC/IF, IHC-P, IP, WB74 ab32505
AKT1 (pS473) Ms, Hu, RatICC, IHC-Fr, IHC-P, WB474 ab81283
AKT1(pS129) Hu, Ms, RatWB33 ab133458
AKT1
Alexa Fluor® 488
HuICC/IF ab204252
AKT1
Alexa Fluor® 647
HuICC/IF ab204285

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ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

AKT1Ms-M
HuWB ab108202
AKT1Ms-MHuICC/IF, IHC-P, WB1 1 ab54752
AKT1/2/3Rb-P Rat, Hu, ELISA, IHC-P, WB1 1 ab79360
AKT1 (pS473) Rb-PMs, AGMkWB2 ab18206
AKT1 (pS473)Rb-PCow, HuICC/IF, IHC-P, WB8 ab8932
AKT1 (pS473)Rb-P Ms, Rat, Chk, Dog, HuDot, ELISA, ICC/IF, IHC-Fr, IHC-P, IP, WB9 15 ab66138
AKT1 (pT308)Rb-P Ms, Rat, Hu, , Cow, Xl, MMLV, Chk, DogDot, ELISA, IHC-P, IP, WB3 2 ab66134
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キット

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製品番号

AKT1 Total ELISA Kit Hu, Ms1x96testsab176637
AKT1 ELISA Kit Hu1x96testsab214023
AKT 1/2/3 (pS473) ELISA Kit Hu, Ms1x96testsab176635
AKT 1/2/3 (pS473) + AKT1 (Total) ELISA Kit Hu, Ms, Rat1x96testsab176657
AKT 1/2/3 (pT308) + AKT1 (Total) ELISA Kit Hu, Ms1x96testsab176658
AKT 1/2/3 (pT308) ELISA Kit Hu, Ms1x96testsab176636
キット一覧

タンパク質・ペプチド

製品名

由来

適用・アプリケーション

製品番号

AKT1 full length protein(Active)HuFuncS, SDS-PAGE, WBab79792
AKT1 full length protein(Active)HuFuncS, SDS-PAGEab62279
AKT1 (mutated E17 K) full length protein(Active)HuFuncS, SDS-PAGEab177268
AKT1 peptide(Active)HuBLab39919
タンパク質・ペプチド製品一覧

インヒビター

製品名

解説

製品番号

Akt Inhibitor (Akti-1/2)Potent isozyme selective Akt1/2 kinase inhibitorab142088
CAY10567Akt1 translocation inhibitorab144433
Alt インヒビター一覧

Akt1 について

Function
機能
Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity).
Tissue specificity
組織特異性
Expressed in all human cell types so far analyzed. The Tyr-176 phosphorylated form shows a significant increase in expression in breast cancers during the progressive stages i.e. normal to hyperplasia (ADH), ductal carcinoma in situ (DCIS), invasive ductal carcinoma (IDC) and lymph node metastatic (LNMM) stages.
Involvement in disease
疾患関連性
Defects in AKT1 are a cause of susceptibility to breast cancer (BC) [MIM:114480]. A common malignancy originating from breast epithelial tissue.Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case. Defects in AKT1 are associated with colorectal cancer (CRC) [MIM:114500]. Defects in AKT1 are associated with susceptibility to ovarian cancer [MIM:604370]; also called susceptibility to familial breast-ovarian cancer type 1 (BROVCA1).
Sequence similarities
配列類似性
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.
Post-translational modifications
翻訳後修飾
Phosphorylation on Thr-308, Ser-473 and Tyr-474 is required for full activity. Activated TNK2 phosphorylates it on Tyr-176 resulting in its binding to the anionic plasma membrane phospholipid PA. This phosphorylated form localizes to the cell membrane, where it is targeted by PDPK1 and PDPK2 for further phosphorylations on Thr-308 and Ser-473 leading to its activation. Ser-473 phosphorylation by mTORC2 favors Thr-308 phosphorylation by PDPK1. Ser-473 phosphorylation is enhanced by interaction with AGAP2 isoform 2 (PIKE-A). Ser-473 phosphorylation is enhanced in focal cortical dysplasias with Taylor-type balloon cells.
Cellular localization
細胞内局在
Cytoplasm. Nucleus. Cell membrane.

関連リンク


Cancer
ポータル

注目ターゲット


Alexa Fluor® is a registered trademark of Life Technologies. Alexa Fluor® dye conjugates contain(s) technology licensed to Abcam by Life Technologies.



ウサギ・モノクローナル 抗体

ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

AKT1Hu, MsFlow Cyt, ICC/IF, IHC-P, IP, WB74 ab32505
AKT1 (pS473) Ms, Hu, RatICC, IHC-Fr, IHC-P, WB474 ab81283
AKT1(pS129) Hu, Ms, RatWB33 ab133458
AKT1
Alexa Fluor® 488
HuICC/IF ab204252
AKT1
Alexa Fluor® 647
HuICC/IF ab204285

抗体

ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

AKT1Ms-M
HuWB ab108202
AKT1Ms-MHuICC/IF, IHC-P, WB1 1 ab54752
AKT1/2/3Rb-P Rat, Hu, ELISA, IHC-P, WB1 1 ab79360
AKT1 (pS473) Rb-PMs, AGMkWB2 ab18206
AKT1 (pS473)Rb-PCow, HuICC/IF, IHC-P, WB8 ab8932
AKT1 (pS473)Rb-P Ms, Rat, Chk, Dog, HuDot, ELISA, ICC/IF, IHC-Fr, IHC-P, IP, WB9 15 ab66138
AKT1 (pT308)Rb-P Ms, Rat, Hu, , Cow, Xl, MMLV, Chk, DogDot, ELISA, IHC-P, IP, WB3 2 ab66134
抗体一覧

キット

製品名

交差種

容量

製品番号

AKT1 Total ELISA Kit Hu, Ms1x96testsab176637
AKT1 ELISA Kit Hu1x96testsab214023
AKT 1/2/3 (pS473) ELISA Kit Hu, Ms1x96testsab176635
AKT 1/2/3 (pS473) + AKT1 (Total) ELISA Kit Hu, Ms, Rat1x96testsab176657
AKT 1/2/3 (pT308) + AKT1 (Total) ELISA Kit Hu, Ms1x96testsab176658
AKT 1/2/3 (pT308) ELISA Kit Hu, Ms1x96testsab176636
キット一覧

タンパク質・ペプチド

製品名

由来

適用・アプリケーション

製品番号

AKT1 full length protein(Active)HuFuncS, SDS-PAGE, WBab79792
AKT1 full length protein(Active)HuFuncS, SDS-PAGEab62279
AKT1 (mutated E17 K) full length protein(Active)HuFuncS, SDS-PAGEab177268
AKT1 peptide(Active)HuBLab39919
タンパク質・ペプチド製品一覧

インヒビター

製品名

解説

製品番号

Akt Inhibitor (Akti-1/2)Potent isozyme selective Akt1/2 kinase inhibitorab142088
CAY10567Akt1 translocation inhibitorab144433
Alt インヒビター一覧

Akt1 について

Function
機能
Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity).
Tissue specificity
組織特異性
Expressed in all human cell types so far analyzed. The Tyr-176 phosphorylated form shows a significant increase in expression in breast cancers during the progressive stages i.e. normal to hyperplasia (ADH), ductal carcinoma in situ (DCIS), invasive ductal carcinoma (IDC) and lymph node metastatic (LNMM) stages.
Involvement in disease
疾患関連性
Defects in AKT1 are a cause of susceptibility to breast cancer (BC) [MIM:114480]. A common malignancy originating from breast epithelial tissue.Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case. Defects in AKT1 are associated with colorectal cancer (CRC) [MIM:114500]. Defects in AKT1 are associated with susceptibility to ovarian cancer [MIM:604370]; also called susceptibility to familial breast-ovarian cancer type 1 (BROVCA1).
Sequence similarities
配列類似性
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.
Post-translational modifications
翻訳後修飾
Phosphorylation on Thr-308, Ser-473 and Tyr-474 is required for full activity. Activated TNK2 phosphorylates it on Tyr-176 resulting in its binding to the anionic plasma membrane phospholipid PA. This phosphorylated form localizes to the cell membrane, where it is targeted by PDPK1 and PDPK2 for further phosphorylations on Thr-308 and Ser-473 leading to its activation. Ser-473 phosphorylation by mTORC2 favors Thr-308 phosphorylation by PDPK1. Ser-473 phosphorylation is enhanced by interaction with AGAP2 isoform 2 (PIKE-A). Ser-473 phosphorylation is enhanced in focal cortical dysplasias with Taylor-type balloon cells.
Cellular localization
細胞内局在
Cytoplasm. Nucleus. Cell membrane.

関連リンク


Cancer
ポータル

注目ターゲット


Alexa Fluor® is a registered trademark of Life Technologies. Alexa Fluor® dye conjugates contain(s) technology licensed to Abcam by Life Technologies.


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