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GATA ~ 注目ターゲットのおすすめ製品


ウサギ・モノクローナル 抗体

ターゲット名

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適用・アプリケーション

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Abreview
数 評価

製品番号

GATA1 HuChIP, ICC/IF, IHC-P, IP, WB ab181544
GATA2Hu, Ms, RatIP, WB ab109241
GATA3 Hu, Ms, RatICC/IF, IHC-P, WB ab199428
GATA2 + GATA3 Hu, Ms, RatICC/IF, IHC-P, IP, WB ab182747
GATA3
(phospho S308)
HuDot, IHC-P, IP, WB ab186371
GATA4Hu, Ms, RatFlow Cyt, ICC/IF, WB2 ab134057
GATA4
Alexa Fluor® 488
HuFlow Cyt, ICC/IF ab194071
GATA4
Alexa Fluor® 568
HuICC/IF ab202522
GATA4
Alexa Fluor® 594
HuICC/IF ab202521
GATA4
Alexa Fluor® 647
HuFlow Cyt, ICC/IF ab194072
GATA6 HuICC/IF, WB ab175927

抗体

ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

GATA1Rb-PHu, MsELISA, ICC/IF, IHC-P, IP, WB42 ab28839
GATA2Rb-P Hu, ZfshChIP, EMSA, IHC-Fr, IHC-P, WB63 ab22849
GATA3Rb-PHu, Ms, RatICC/IF, IHC-P, WB11 ab106625
GATA4Rb-PHu, Ms, Rat, RMkICC/IF, IHC-Fr, IHC-P, WB38 ab84593
GATA4Rb-PMs, Rat, DogEMSA, ICC/IF, IHC-Fr, WB71 ab5245
GATA4Rb-PHu, RatELISA, ICC/IF, IHC-P, WB63 ab61767
GATA5Rb-P HuIHC-P, WB ab118777
GATA5Rb-PMsELISA, ICC/IF, WB1 ab48820
GATA6Rb-PHu, Ms, RatICC/IF, IHC-P, WB93 ab22600
抗体一覧

タンパク質・ペプチド

製品名

由来

適用・アプリケーション

製品番号

GATA1 full length proteinHuSDS-PAGEab204189
GATA2 full length proteinHuELISA, SDS-PAGE, WBab114360
GATA3 protein fragmentHuELISA, SDS-PAGE, WBab112288
GATA4 protein fragmentHuELISA, SDS-PAGE, WBab112289
GATA5 full length proteinHuELISA, WBab165464
GATA6 protein fragmentHuELISA, SDS-PAGE, WBab114316
タンパク質・ペプチド一覧

キット

製品名

交差種

容量

製品番号

GATA (GATA1, GATA2, GATA3) Transcription Factor Assay Kit (Colorimetric) Hu 2x96testsab207205
GATA-4 Transcription Factor Assay Kit (Colorimetric) Hu 5x96tests
1x96tests
ab207206
キット一覧

ポジティブ・コントロール

製品名

解説

適用・アプリケーション

製品番号

GATA3 293T Transfected Lysate ab94325 is a 293T cell transfected lysate in which Human GATA3 has been transiently over-expressed using a pCMV-GATA3 plasmid. WBab94325

GATA について

造血系細胞あるいは中胚葉・内胚葉系細胞の分化、増殖、成長を制御する、GATA1~GATA6 からなる転写因子ファミリーであり、分化・発生の分野で広く研究されています。

GATA1
Function
機能
Transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells.
Tissue specificity
組織特異性
Erythrocytes
Involvement in disease
疾患関連性
Defects in GATA1 are the cause of X-linked dyserythropoietic anemia and thrombocytopenia (XDAT) [MIM:300367]. XDAT is a disorder characterized by erythrocytes with abnormal size and shape, and paucity of platelets in peripheral blood. The bone marrow contains abundant and abnormally small megakaryocytes.
Defects in GATA1 are the cause of X-linked thrombocytopenia with beta-thalassemia (XLTT) [MIM:314050]; also knwon as thrombocytopenia, platelet dysfunction, hemolysis, and imbalanced globin synthesis. XLTT consists of an unusual form of thrombocytopenia with beta-thalassemia. Patients have splenomegaly and petechiae, moderate thrombocytopenia, prolonged bleeding time due to platelet dysfunction, reticulocytosis and unbalanced hemoglobin chain synthesis resembling that of beta-thalassemia minor.
Defects in GATA1 are the cause of anemia without thrombocytopenia X-linked (XLAWT) [MIM:300835]. XLAWT is a form of anemia characterized by abnormal morphology of erythrocytes and granulocytes in peripheral blood, bone marrow dysplasia with hypocellularity of erythroid and granulocytic lineages, and normal or increased number of megakaryocytes. Neutropenia of a variable degree is present in affected individuals.
Sequence similarities
配列類似性
Contains 2 GATA-type zinc fingers.
Domain
ドメイン
The two fingers are functionally distinct and cooperate to achieve specific, stable DNA binding. The first finger is necessary only for full specificity and stability of binding, whereas the second one is required for binding.
Cellular localization
細胞内局在性
Nucleus
Database links
参照データベース
Entrez Gene: 2623 (Human) Omim: 305371 (Human) SwissProt: P15976 (Human) Unigene: 765 (Human)
GATA2
Function
機能
Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'.
Tissue specificity
組織特異性
Endothelial cells
Sequence similarities
配列類似性
Contains 2 GATA-type zinc fingers
Cellular localization
細胞内局在性
Nucleus
Database links
参照データベース
Entrez Gene: 2624 (Human)   Entrez Gene: 14461 (Mouse) Entrez Gene: 25159 (Rat) Omim: 137295 (Human) SwissProt: P23769 (Human) SwissProt: O09100 (Mouse) SwissProt: Q924Y4 (Rat) Unigene: 367725 Human
GATA3

GATA の DNA 配列をコア認識配列とする DNA 結合タンパク質。通常、転写活性化因子として働く。血球系 GATA ファミリータンパク質 (GATA1-GATA3) の1つ。 羊土社 実験医学増刊 Vol.27 No.20 特集 「アレルギー疾患の免疫機構」 より

Function
機能
Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'.
Tissue specificity
組織特異性
T-cells and endothelial cells
Involvement in disease
疾患関連性
Defects in GATA3 are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia (HDR) [MIM:146255]; also known as Barakat syndrome.
Sequence similarities
配列類似性
Contains 2 GATA-type zinc fingers
Cellular localization
細胞内局在性
Nucleus
Database links
参照データベース
Entrez Gene: 2625 (Human) Entrez Gene: 14462 (Mouse) Omim: 131320 (Human) SwissProt: P23771 (Human) SwissProt: P23772 (Mouse) Unigene: 524134 (Human) Unigene: 313866 (Mouse)
Form
製品の状態
There are 2 isoforms produced by alternative splicing
GATA4
Function
機能
Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3'. Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement.
Involvement in disease
疾患関連性
Defects in GATA4 are the cause of atrial septal defect type 2 (ASD2) [MIM:607941]. ASD2 is a congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria. ASD2 patients show other heart abnormalities including ventricular and atrioventricular septal defects, pulmonary valve thickening or insufficiency of the cardiac valves. ASD2 is not associated with defects in the cardiac conduction system or non-cardiac abnormalities.
Defects in GATA4 are a cause of ventricular septal defect type 1 (VSD1) [MIM:614429]. VSD1 is a common form of congenital cardiovascular anomaly that may occur alone or in combination with other cardiac malformations. It can affect any portion of the ventricular septum, resulting in abnormal communications between the two lower chambers of the heart. Classification is based on location of the communication, such as perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular defect. Large defects that go unrepaired may give rise to cardiac enlargement, congestive heart failure, pulmonary hypertension, Eisenmenger's syndrome, delayed fetal brain development, arrhythmias, and even sudden cardiac death.
Defects in GATA4 are a cause of tetralogy of Fallot (TOF) [MIM:187500]. TOF is a congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. In this condition, blood from both ventricles (oxygen-rich and oxygen-poor) is pumped into the body often causing cyanosis. Defects in GATA4 are the cause of atrioventricular septal defect type 4 (AVSD4) [MIM:614430]. A congenital heart malformation characterized by a common atrioventricular junction coexisting with deficient atrioventricular septation. The complete form involves underdevelopment of the lower part of the atrial septum and the upper part of the ventricular septum; the valve itself is also shared. A less severe form, known as ostium primum atrial septal defect, is characterized by separate atrioventricular valvar orifices despite a common junction.
Sequence similarities
配列類似性
Contains 2 GATA-type zinc fingers.
Database links
参照データベース
Entrez Gene: 2626 (Human) Entrez Gene: 14463 (Mouse)  Omim: 600576 (Human)SwissProt: P43694 (Human) SwissProt: Q08369 (Mouse) Unigene: 243987 (Human) Unigene: 247669 (Mouse) Unigene: 26251 (Rat)
GATA5
Function
機能
Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer. May play an important role in the transcriptional program(s) that underlies smooth muscle cell diversity.
Sequence similarities
配列類似性
Contains 2 GATA-type zinc fingers.
Database links
参照データベース
Entrez Gene: 140628 (Human) Entrez Gene: 14464 (Mouse) Entrez Gene: 499951 (Rat) SwissProt: Q9BWX5 (Human)SwissProt: P97489 (Mouse) SwissProt: Q5U2V0 (Rat) Unigene: 352250 (Human  Unigene: 388880 Mouse
GATA6
Function
機能
Thought to be important for regulating terminal differentiation and/or proliferation.
Tissue specificity
組織特異性
Expressed in heart, gut and gut-derived tissues.
Sequence similarities
配列類似性
Contains 2 GATA-type zinc fingers.
Domain
ドメイン
The GATA-type zinc fingers mediate interaction with LMCD1.
Database links
参照データベース
Entrez Gene: 2627 (Human) Entrez Gene: 14465 (Mouse) Entrez Gene: 397600 (Pig) Entrez Gene: 29300 (Rat) Omim: 601656 (Human) SwissProt: P43693 (Chicken) SwissProt: Q92908 (Human) SwissProt: Q61169 (Mouse) SwissProt: Q95JA5 (Pig) SwissProt: P46153 (Rat) Unigene: 514746 (Human) Unigene: 329287 (Mouse) Unigene: 8701 (Rat)

関連リンク


Immunology
ポータル

注目ターゲット

Alexa Fluor® is a registered trademark of Life Technologies. Alexa Fluor® dye conjugates contain(s) technology licensed to Abcam by Life Technologies.



ウサギ・モノクローナル 抗体

ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

GATA1 HuChIP, ICC/IF, IHC-P, IP, WB ab181544
GATA2Hu, Ms, RatIP, WB ab109241
GATA3 Hu, Ms, RatICC/IF, IHC-P, WB ab199428
GATA2 + GATA3 Hu, Ms, RatICC/IF, IHC-P, IP, WB ab182747
GATA3
(phospho S308)
HuDot, IHC-P, IP, WB ab186371
GATA4Hu, Ms, RatFlow Cyt, ICC/IF, WB2 ab134057
GATA4
Alexa Fluor® 488
HuFlow Cyt, ICC/IF ab194071
GATA4
Alexa Fluor® 568
HuICC/IF ab202522
GATA4
Alexa Fluor® 594
HuICC/IF ab202521
GATA4
Alexa Fluor® 647
HuFlow Cyt, ICC/IF ab194072
GATA6 HuICC/IF, WB ab175927

抗体

ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

GATA1Rb-PHu, MsELISA, ICC/IF, IHC-P, IP, WB42 ab28839
GATA2Rb-P Hu, ZfshChIP, EMSA, IHC-Fr, IHC-P, WB63 ab22849
GATA3Rb-PHu, Ms, RatICC/IF, IHC-P, WB11 ab106625
GATA4Rb-PHu, Ms, Rat, RMkICC/IF, IHC-Fr, IHC-P, WB38 ab84593
GATA4Rb-PMs, Rat, DogEMSA, ICC/IF, IHC-Fr, WB71 ab5245
GATA4Rb-PHu, RatELISA, ICC/IF, IHC-P, WB63 ab61767
GATA5Rb-P HuIHC-P, WB ab118777
GATA5Rb-PMsELISA, ICC/IF, WB1 ab48820
GATA6Rb-PHu, Ms, RatICC/IF, IHC-P, WB93 ab22600
抗体一覧

タンパク質・ペプチド

製品名

由来

適用・アプリケーション

製品番号

GATA1 full length proteinHuSDS-PAGEab204189
GATA2 full length proteinHuELISA, SDS-PAGE, WBab114360
GATA3 protein fragmentHuELISA, SDS-PAGE, WBab112288
GATA4 protein fragmentHuELISA, SDS-PAGE, WBab112289
GATA5 full length proteinHuELISA, WBab165464
GATA6 protein fragmentHuELISA, SDS-PAGE, WBab114316
タンパク質・ペプチド一覧

キット

製品名

交差種

容量

製品番号

GATA (GATA1, GATA2, GATA3) Transcription Factor Assay Kit (Colorimetric) Hu 2x96testsab207205
GATA-4 Transcription Factor Assay Kit (Colorimetric) Hu 5x96tests
1x96tests
ab207206
キット一覧

ポジティブ・コントロール

製品名

解説

適用・アプリケーション

製品番号

GATA3 293T Transfected Lysate ab94325 is a 293T cell transfected lysate in which Human GATA3 has been transiently over-expressed using a pCMV-GATA3 plasmid. WBab94325

GATA について

造血系細胞あるいは中胚葉・内胚葉系細胞の分化、増殖、成長を制御する、GATA1~GATA6 からなる転写因子ファミリーであり、分化・発生の分野で広く研究されています。

GATA1
Function
機能
Transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells.
Tissue specificity
組織特異性
Erythrocytes
Involvement in disease
疾患関連性
Defects in GATA1 are the cause of X-linked dyserythropoietic anemia and thrombocytopenia (XDAT) [MIM:300367]. XDAT is a disorder characterized by erythrocytes with abnormal size and shape, and paucity of platelets in peripheral blood. The bone marrow contains abundant and abnormally small megakaryocytes.
Defects in GATA1 are the cause of X-linked thrombocytopenia with beta-thalassemia (XLTT) [MIM:314050]; also knwon as thrombocytopenia, platelet dysfunction, hemolysis, and imbalanced globin synthesis. XLTT consists of an unusual form of thrombocytopenia with beta-thalassemia. Patients have splenomegaly and petechiae, moderate thrombocytopenia, prolonged bleeding time due to platelet dysfunction, reticulocytosis and unbalanced hemoglobin chain synthesis resembling that of beta-thalassemia minor.
Defects in GATA1 are the cause of anemia without thrombocytopenia X-linked (XLAWT) [MIM:300835]. XLAWT is a form of anemia characterized by abnormal morphology of erythrocytes and granulocytes in peripheral blood, bone marrow dysplasia with hypocellularity of erythroid and granulocytic lineages, and normal or increased number of megakaryocytes. Neutropenia of a variable degree is present in affected individuals.
Sequence similarities
配列類似性
Contains 2 GATA-type zinc fingers.
Domain
ドメイン
The two fingers are functionally distinct and cooperate to achieve specific, stable DNA binding. The first finger is necessary only for full specificity and stability of binding, whereas the second one is required for binding.
Cellular localization
細胞内局在性
Nucleus
Database links
参照データベース
Entrez Gene: 2623 (Human) Omim: 305371 (Human) SwissProt: P15976 (Human) Unigene: 765 (Human)
GATA2
Function
機能
Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'.
Tissue specificity
組織特異性
Endothelial cells
Sequence similarities
配列類似性
Contains 2 GATA-type zinc fingers
Cellular localization
細胞内局在性
Nucleus
Database links
参照データベース
Entrez Gene: 2624 (Human)   Entrez Gene: 14461 (Mouse) Entrez Gene: 25159 (Rat) Omim: 137295 (Human) SwissProt: P23769 (Human) SwissProt: O09100 (Mouse) SwissProt: Q924Y4 (Rat) Unigene: 367725 Human
GATA3

GATA の DNA 配列をコア認識配列とする DNA 結合タンパク質。通常、転写活性化因子として働く。血球系 GATA ファミリータンパク質 (GATA1-GATA3) の1つ。 羊土社 実験医学増刊 Vol.27 No.20 特集 「アレルギー疾患の免疫機構」 より

Function
機能
Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'.
Tissue specificity
組織特異性
T-cells and endothelial cells
Involvement in disease
疾患関連性
Defects in GATA3 are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia (HDR) [MIM:146255]; also known as Barakat syndrome.
Sequence similarities
配列類似性
Contains 2 GATA-type zinc fingers
Cellular localization
細胞内局在性
Nucleus
Database links
参照データベース
Entrez Gene: 2625 (Human) Entrez Gene: 14462 (Mouse) Omim: 131320 (Human) SwissProt: P23771 (Human) SwissProt: P23772 (Mouse) Unigene: 524134 (Human) Unigene: 313866 (Mouse)
Form
製品の状態
There are 2 isoforms produced by alternative splicing
GATA4
Function
機能
Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3'. Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement.
Involvement in disease
疾患関連性
Defects in GATA4 are the cause of atrial septal defect type 2 (ASD2) [MIM:607941]. ASD2 is a congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria. ASD2 patients show other heart abnormalities including ventricular and atrioventricular septal defects, pulmonary valve thickening or insufficiency of the cardiac valves. ASD2 is not associated with defects in the cardiac conduction system or non-cardiac abnormalities.
Defects in GATA4 are a cause of ventricular septal defect type 1 (VSD1) [MIM:614429]. VSD1 is a common form of congenital cardiovascular anomaly that may occur alone or in combination with other cardiac malformations. It can affect any portion of the ventricular septum, resulting in abnormal communications between the two lower chambers of the heart. Classification is based on location of the communication, such as perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular defect. Large defects that go unrepaired may give rise to cardiac enlargement, congestive heart failure, pulmonary hypertension, Eisenmenger's syndrome, delayed fetal brain development, arrhythmias, and even sudden cardiac death.
Defects in GATA4 are a cause of tetralogy of Fallot (TOF) [MIM:187500]. TOF is a congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. In this condition, blood from both ventricles (oxygen-rich and oxygen-poor) is pumped into the body often causing cyanosis. Defects in GATA4 are the cause of atrioventricular septal defect type 4 (AVSD4) [MIM:614430]. A congenital heart malformation characterized by a common atrioventricular junction coexisting with deficient atrioventricular septation. The complete form involves underdevelopment of the lower part of the atrial septum and the upper part of the ventricular septum; the valve itself is also shared. A less severe form, known as ostium primum atrial septal defect, is characterized by separate atrioventricular valvar orifices despite a common junction.
Sequence similarities
配列類似性
Contains 2 GATA-type zinc fingers.
Database links
参照データベース
Entrez Gene: 2626 (Human) Entrez Gene: 14463 (Mouse)  Omim: 600576 (Human)SwissProt: P43694 (Human) SwissProt: Q08369 (Mouse) Unigene: 243987 (Human) Unigene: 247669 (Mouse) Unigene: 26251 (Rat)
GATA5
Function
機能
Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer. May play an important role in the transcriptional program(s) that underlies smooth muscle cell diversity.
Sequence similarities
配列類似性
Contains 2 GATA-type zinc fingers.
Database links
参照データベース
Entrez Gene: 140628 (Human) Entrez Gene: 14464 (Mouse) Entrez Gene: 499951 (Rat) SwissProt: Q9BWX5 (Human)SwissProt: P97489 (Mouse) SwissProt: Q5U2V0 (Rat) Unigene: 352250 (Human  Unigene: 388880 Mouse
GATA6
Function
機能
Thought to be important for regulating terminal differentiation and/or proliferation.
Tissue specificity
組織特異性
Expressed in heart, gut and gut-derived tissues.
Sequence similarities
配列類似性
Contains 2 GATA-type zinc fingers.
Domain
ドメイン
The GATA-type zinc fingers mediate interaction with LMCD1.
Database links
参照データベース
Entrez Gene: 2627 (Human) Entrez Gene: 14465 (Mouse) Entrez Gene: 397600 (Pig) Entrez Gene: 29300 (Rat) Omim: 601656 (Human) SwissProt: P43693 (Chicken) SwissProt: Q92908 (Human) SwissProt: Q61169 (Mouse) SwissProt: Q95JA5 (Pig) SwissProt: P46153 (Rat) Unigene: 514746 (Human) Unigene: 329287 (Mouse) Unigene: 8701 (Rat)

関連リンク


Immunology
ポータル

注目ターゲット

Alexa Fluor® is a registered trademark of Life Technologies. Alexa Fluor® dye conjugates contain(s) technology licensed to Abcam by Life Technologies.


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