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Histone H4 ~ 注目ターゲットのおすすめ製品


ヒストン H4 抗体

ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

Unmodified
抗体一覧
Rb-PDm, Hu, Ms, Rat, Sc, XlChIP, ICC/IF, IHC-P, IP, WB4216 ab10158
Unmodified
抗体一覧
Rb-PHu, Ms, Cow, ScChIP, ICC/IF, IHC-P, WB218 ab7311
Unmodified
抗体一覧
Mouse-MonoHu, CowChIP, Flow Cyt, ICC/IF, IHC-P, IP, WB61 ab31830

修飾ヒストン H4 抗体

ターゲット名

交差種

適用・アプリケーション

文献

Abreview
数 評価

製品番号

acetyl K5
抗体一覧
Ms, Rat, Hu, Rice, XlChIP, ICC/IF, IHC-P, IP, WB173 ab51997
acetyl K8
抗体一覧
Hu, Ms, RatChIP, ICC/IF, IHC-P, IP, WB4 ab45166
acetyl K8
抗体一覧
Rb-P Ms, Cow, Hu, Sc, S pom, ChkChIP, EM, ICC/IF, IHC-P, WB183 ab15823
acetyl K12
抗体一覧
Rb-P Ms, Hu, Sc, XlChIP, Dot, ICC/IF, IP, WB74 ab46983
mono methyl K20
抗体一覧
Rb-PHu, Ms, Ce, Cow, Dm, S pomChIP, CHIPseq, Flow Cyt, ICC/IF, IHC-Fr, IHC-P, WB3312 ab9051
di methyl K20
抗体一覧
Rb-P Ms, Cow, Hu, S pom, Tx ggChIP, ICC/IF, IHC-P, IP, WB155 ab9052
di methyl K79
抗体一覧
Rb-P Cow, HuICC, ICC/IF, IHC-P, WB12 ab2885
Tri methyl K20
抗体一覧
Rb-P Ms, Rat, Cow, Hu, S pom, Tx ggChIP, ChIP/Chip, EM, Flow Cyt, ICC/IF, IHC (PFA fixed), IHC-Fr, IHC-P, WB7014 ab9053
Tri methyl K20
抗体一覧
Ms-M Hu, Ce, MsDot, ELISA, Flow Cyt, ICC/IF, IHC-P, WB32 ab78517
Phospho S47
抗体一覧
Rb-PHu, Ms, RatELISA, ICC/IF, WB2 ab61061
ヒストン H4 抗体全製品リスト

タンパク質・ペプチド

製品名

由来

適用・アプリケーション

製品番号

Histone H4 protein(Unmodified)(Recombinant)HuELISA, SDS-PAGE, WBab112431
Histone H4 peptide(Unmodified)Huab14963
Histone H4 peptide(acetyl K12)HuBLab15662
Histone H4 peptide(acetyl K16)Huab154464
Histone H4 peptide(di methyl K20)HuBL, Dotab14964
Histone H4 peptide(Phospho S1)Huab14724
タンパク質・ペプチド一覧

キット

製品名

交差種

容量

製品番号

Histone H4 Total Quantification Kit (Fluorometric)Ms, Rat, Hu96test
48test
ab156909
Histone H4 (mono-methyl K20) Quantification Kit (Colorimetric)Hu, Ms96test
48test
ab115093
Histone H4 (mono-methyl K20) Quantification Kit (Fluorometric)Hu, Ms96test
48test
ab115094
Histone H4 Total Acetylation Detection Fast Kit (Fluorometric)Hu, Ms96test
48test
ab131562
キット一覧

Histone H4 について

Function
機能
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Sequence similarities
配列類似性
Belongs to the histone H4 family.
Post-translational modifications
翻訳後修飾
  • Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin. Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
  • Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
  • Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by SET8. Trimethylation is performed by SUV420H1 and SUV420H2 and induces gene silencing.
  • Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me).
  • Cellular localization
    細胞内局在
    Nucleus. Chromosome.

    関連リンク


    Epigenetics
    ポータル

    注目ターゲット

    Histone H3
    抗体とキット

    エピジェネティック修飾
    検出キット


    Chromatin structure & function (英文)

    Histone modifications guide (英文)

    ChIPseq webinar (英語)


    ヒストン H4 抗体

    ターゲット名

    交差種

    適用・アプリケーション

    文献

    Abreview
    数 評価

    製品番号

    Unmodified
    抗体一覧
    Rb-PDm, Hu, Ms, Rat, Sc, XlChIP, ICC/IF, IHC-P, IP, WB4216 ab10158
    Unmodified
    抗体一覧
    Rb-PHu, Ms, Cow, ScChIP, ICC/IF, IHC-P, WB218 ab7311
    Unmodified
    抗体一覧
    Mouse-MonoHu, CowChIP, Flow Cyt, ICC/IF, IHC-P, IP, WB61 ab31830

    修飾ヒストン H4 抗体

    ターゲット名

    交差種

    適用・アプリケーション

    文献

    Abreview
    数 評価

    製品番号

    acetyl K5
    抗体一覧
    Ms, Rat, Hu, Rice, XlChIP, ICC/IF, IHC-P, IP, WB173 ab51997
    acetyl K8
    抗体一覧
    Hu, Ms, RatChIP, ICC/IF, IHC-P, IP, WB4 ab45166
    acetyl K8
    抗体一覧
    Rb-P Ms, Cow, Hu, Sc, S pom, ChkChIP, EM, ICC/IF, IHC-P, WB183 ab15823
    acetyl K12
    抗体一覧
    Rb-P Ms, Hu, Sc, XlChIP, Dot, ICC/IF, IP, WB74 ab46983
    mono methyl K20
    抗体一覧
    Rb-PHu, Ms, Ce, Cow, Dm, S pomChIP, CHIPseq, Flow Cyt, ICC/IF, IHC-Fr, IHC-P, WB3312 ab9051
    di methyl K20
    抗体一覧
    Rb-P Ms, Cow, Hu, S pom, Tx ggChIP, ICC/IF, IHC-P, IP, WB155 ab9052
    di methyl K79
    抗体一覧
    Rb-P Cow, HuICC, ICC/IF, IHC-P, WB12 ab2885
    Tri methyl K20
    抗体一覧
    Rb-P Ms, Rat, Cow, Hu, S pom, Tx ggChIP, ChIP/Chip, EM, Flow Cyt, ICC/IF, IHC (PFA fixed), IHC-Fr, IHC-P, WB7014 ab9053
    Tri methyl K20
    抗体一覧
    Ms-M Hu, Ce, MsDot, ELISA, Flow Cyt, ICC/IF, IHC-P, WB32 ab78517
    Phospho S47
    抗体一覧
    Rb-PHu, Ms, RatELISA, ICC/IF, WB2 ab61061
    ヒストン H4 抗体全製品リスト

    タンパク質・ペプチド

    製品名

    由来

    適用・アプリケーション

    製品番号

    Histone H4 protein(Unmodified)(Recombinant)HuELISA, SDS-PAGE, WBab112431
    Histone H4 peptide(Unmodified)Huab14963
    Histone H4 peptide(acetyl K12)HuBLab15662
    Histone H4 peptide(acetyl K16)Huab154464
    Histone H4 peptide(di methyl K20)HuBL, Dotab14964
    Histone H4 peptide(Phospho S1)Huab14724
    タンパク質・ペプチド一覧

    キット

    製品名

    交差種

    容量

    製品番号

    Histone H4 Total Quantification Kit (Fluorometric)Ms, Rat, Hu96test
    48test
    ab156909
    Histone H4 (mono-methyl K20) Quantification Kit (Colorimetric)Hu, Ms96test
    48test
    ab115093
    Histone H4 (mono-methyl K20) Quantification Kit (Fluorometric)Hu, Ms96test
    48test
    ab115094
    Histone H4 Total Acetylation Detection Fast Kit (Fluorometric)Hu, Ms96test
    48test
    ab131562
    キット一覧

    Histone H4 について

    Function
    機能
    Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
    Sequence similarities
    配列類似性
    Belongs to the histone H4 family.
    Post-translational modifications
    翻訳後修飾
  • Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin. Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
  • Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
  • Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by SET8. Trimethylation is performed by SUV420H1 and SUV420H2 and induces gene silencing.
  • Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me).
  • Cellular localization
    細胞内局在
    Nucleus. Chromosome.

    関連リンク


    Epigenetics
    ポータル

    注目ターゲット

    Histone H3
    抗体とキット

    エピジェネティック修飾
    検出キット


    Chromatin structure & function (英文)

    Histone modifications guide (英文)

    ChIPseq webinar (英語)

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