Bisdemethoxycurcumin, Apoptotic curcuminoid (ab120976)
Key features and details
- Apoptotic anticancer, anti-inflammatory and antioxidant curcuminoid
- CAS Number: 33171-05-0
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
Bisdemethoxycurcumin, Apoptotic curcuminoid -
製品の詳細
Apoptotic anticancer, anti-inflammatory and antioxidant curcuminoid -
別名
- BDMC
- Bisdesmethoxycurcumin
- Curcumin III
- Didemethoxycurcumin
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精製度
> 98% -
CAS 番号
33171-05-0 -
構造式
製品の特性
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体系名
(1E,6E)-1,7-Bis(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione -
分子量
308.33 -
分子式
C19H16O4 -
保存方法
Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. -
溶解性
Soluble in DMSO to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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由来
Synthetic
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研究分野
- Biochemicals
- Pharmacology
- Signaling
- Signal transduction
- Nitric oxide & oxidative stress
- Antioxidants
- Biochemicals
- Research Area
- Alzheimer's Disease
- Signaling
- Signal transduction
- Nitric oxide signaling
- Antioxidants
- Biochemicals
- Research Area
- Diabetes
- Signaling
- Signal transduction
- Nitric oxide signaling
- Antioxidants
- Biochemicals
- Research Area
- Hypertension
- Signaling
- Signal transduction
- Nitric oxide signaling
- Antioxidants
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab120976の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
Functional Studies |
Use at an assay dependent concentration.
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特記事項 |
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Functional Studies
Use at an assay dependent concentration. |
画像
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2D chemical structure image of ab120976, Bisdemethoxycurcumin, Apoptotic curcuminoid
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ab18210 staining Bcl2 in HeLa cells treated with bisdemethoxycurcumin (ab120976), by ICC/IF. Decrease of Bcl2 expression correlates with increased concentration of bisdemethoxycurcumin, as described in literature.
The cells were incubated at 37°C for 6 hours in media containing different concentrations of ab120976 (bisdemethoxycurcumin) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab18209 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (0)
ab120976 は論文での使用が確認できていません。