Biotin Anti-alpha 2 Macroglobulin 抗体 (ab7338)

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Key features and details

  • Biotin Goat polyclonal to alpha 2 Macroglobulin
  • Reacts with: Human
  • Conjugation: Biotin
  • Isotype: IgG

製品の概要

  • 製品名

    Biotin Anti-alpha 2 Macroglobulin antibody
    alpha 2 Macroglobulin 一次抗体 製品一覧

  • 製品の詳細

    Biotin Goat polyclonal to alpha 2 Macroglobulin

  • 由来種

    Goat

  • 標識

    Biotin

  • 種交差性

    交差種: Human

  • 免疫原

    Alpha-2-Macroglobulin [Human Plasma]

  • 特記事項

    Biotinamidocaproate N-Hydroxysuccinimide Ester (BAC) Biotin/Protein Ratio: 10-20 BAC molecules per rabbit IgG molecule.

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

製品の特性

  • 製品の状態

    Liquid

  • 保存方法

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.

  • バッファー

    Preservative: 0.01% Sodium azide
    Constituents: 0.88% Sodium chloride, 1% BSA, 0.42% Potassium phosphate
  • Concentration information loading...

  • 精製度

    IgG fraction

  • 特記事項（精製）

    This product is an IgG fraction antibody purified from monospecific antiserum by a multi-step process which includes delipidation, salt fractionation and ion exchange chromatography followed by extensive dialysis against the buffer.

  • ポリ/モノ

    ポリクローナル

  • アイソタイプ

    IgG

  • 研究分野

アプリケーション

追加情報
Immunoblotting (western or dot blot)
ELISA (1:9,000 to 1:36,000)
Immunohistochemistry
Immunomicroscopy
as well as other antibody based assays using streptavidin or avidin conjugates requiring lot-to-lot consistency.

ターゲット情報

  • 機能

    Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

  • 組織特異性

    Secreted in plasma.

  • 配列類似性

    Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.

  • 発生段階

    Contrary to the rat protein, which is an acute phase protein, this protein is always present at high levels in circulation.

  • 細胞内局在

    Secreted.
  • Information by UniProt

  • 参照データベース

    • 別名

      • A2m antibody
      • A2MG_HUMAN antibody
      • Alpha 2 M antibody
      • Alpha 2M antibody
      • Alpha-2-M antibody
      • Alpha-2-macroglobulin antibody
      • C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5 antibody
      • CPAMD5 antibody
      • DKFZp779B086 antibody
      • FWP007 antibody
      • S863 7 antibody
      see all

    参考文献 (1)

    ab7338 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab7338 は 1 報の論文で使用されています。

    • Jensen PE  et al. Significantly increased fractions of transformed to total alpha2-macroglobulin concentrations in plasma from patients with multiple sclerosis. Biochim Biophys Acta 1690:203-7 (2004). ELISA . PubMed: 15511627

    レビューと Q&A

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    Question

    Have the epitopes been determined?

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    Answer

    Thank you for your enquiry. As these 4 antibodies are all polyclonal antibodies, each will recognize multiple epitopes. If you have any more questions, please do contact us again.

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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