製品名Beta Secretase Substrate
Beta secretase キット 製品一覧
This is a component of Beta Secretase Activity Assay (Fluorometric) (ab65357).
保存方法Store at -20°C. Please refer to protocols.
内容 ラベル 200 µl β -Secretase Substrate (in DMSO) Amber NM 1 x 200µl
関連性Beta secretase is a protease responsible for the proteolytic processing of the amyloid precursor protein (APP). Amyloid beta peptide is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimers disease. This peptide is generated from the beta-amyloid precursor protein (beta APP) in a two-step process. The first step involves cleavage of the extracellular, amino-terminal domain of beta APP. Protein cleavage is performed by an aspartyl protease termed beta-secretase (BACE), of which there are two isoforms, BACE1 and 2. Beta APP cleavage by beta-secretase results in the cellular secretion of a segment of beta APP and a membrane-bound remnant. This remnant is then processed by another protease termed gamma-secretase. Gamma-secretase cleaves an intra-membrane site in the carboxyl-terminal domain of beta APP, thus generating the amyloid beta peptide.
細胞内局在Membrane; Single-pass type I membrane protein.
- APP beta secretase
- ASP 2
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.