beta-Amyloid Peptide (25-35) (human), toxic amyloid beta (25-35) protein fragment (ab120480)

製品の概要

  • 製品名

    beta-Amyloid Peptide (25-35) (human), toxic amyloid beta (25-35) protein fragment
  • 製品の詳細

    Highly toxic amyloid beta (25-35) protein fragment
  • 生理活性の詳細

    Highly toxic, synthetic peptide fragment of the amyloid beta protein. Displays extremely rapid aggregation and enhanced neurotoxicity. Increases oxidative stress, causes neuronal damage and decreases spatial memory in rats.

  • 精製度

    > 95%
  • CAS 番号

    131602-53-4
  • 構造式

    Chemical Structure

製品の特性

参考文献

This product has been referenced in:

  • Limón ID  et al. Amyloid-beta(25-35) impairs memory and increases NO in the temporal cortex of rats. Neurosci Res 63:129-37 (2009). Read more (PubMed: 19084561) »
  • Millucci L  et al. Rapid aggregation and assembly in aqueous solution of A beta (25-35) peptide. J Biosci 34:293-303 (2009). Read more (PubMed: 19550045) »
  • Hughes E  et al. Inhibition of toxicity in the beta-amyloid peptide fragment beta -(25-35) using N-methylated derivatives: a general strategy to prevent amyloid formation. J Biol Chem 275:25109-15 (2000). Read more (PubMed: 10825171) »

レビューと Q&A

1-2 of 2 Abreviews or Q&A

Answer

Thank you for your response.

Unfortunately we don’t have any specific data for this compound. However,this product has been used in the paper attached. The materials and methods section describes how they used PBS to dissolve the compound and incubated it for an hour before use in experiments.

http://ops.adminsite.com/admin/abcamshare/CRM/attach/2012/4/23/CCE3705841_Alzheimer’sβ-Amyloid-InducedDepolarizationofskeletamusclefibers_implicationsformotordysfunctionsindememntia.pdf

Provided storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months. Solubility is temperature dependent. As such, cooling or freezing solutions may lead to precipitation of the product from solution. It is therefore important to ensure that your product is completely re-dissolved before use.

If you need any further assistance, please do not hesitate to contact me.

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Answer

Thank you providing the product code number and the order number in your previous e-mail. I am very sorry to hear that you are having problems with this antibody.

Could you provide some further details of the protocol used? Are you using it in ELISA assay or function or inhibition assay?

I look forward to hearing from you soon.

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