Key features and details
- Rabbit polyclonal to BACH1/BRIP1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
BACH1/BRIP1 一次抗体 製品一覧
製品の詳細Rabbit polyclonal to BACH1/BRIP1
アプリケーション適用あり: WBmore details
Synthetic peptide, corresponding to amino acids 1233-1249 of Human BACH1.
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保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Preservative: 0.02% Sodium azide
Concentration information loading...
精製度Immunogen affinity purified
Our Abpromise guarantee covers the use of ab7288 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/1000. Detects a band of approximately 130 kDa (predicted molecular weight: 140 kDa).|
機能DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1.
組織特異性Ubiquitously expressed, with highest levels in testis.
関連疾患Defects in BRIP1 are a cause of susceptibility to breast cancer (BC) [MIM:114480]. A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case.
Defects in BRIP1 are the cause of Fanconi anemia complementation group J (FANCJ) [MIM:609054]. It is a disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.
配列類似性Belongs to the DEAD box helicase family. DEAH subfamily.
Contains 1 helicase ATP-binding domain.
ドメイン4Fe-4S iron-sulfur-binding is required for helicase activity (PubMed:20639400).
翻訳後修飾Phosphorylated. Phosphorylation is necessary for interaction with BRCA1, and is cell-cycle regulated.
- Information by UniProt
- ATP dependent RNA helicase BRIP1 antibody
- ATP-dependent RNA helicase BRIP1 antibody
- BACH 1 antibody
ab7288 は 2 報の論文で使用されています。
- Monteiro LJ et al. The Forkhead Box M1 protein regulates BRIP1 expression and DNA damage repair in epirubicin treatment. Oncogene : (2012). PubMed: 23108394
- van Wietmarschen N et al. The Mammalian Proteins MMS19, MIP18, and ANT2 Are Involved in Cytoplasmic Iron-Sulfur Cluster Protein Assembly. J Biol Chem 287:43351-8 (2012). WB . PubMed: 23150669