Key features and details
- Rabbit polyclonal to BACE2
- Suitable for: IHC-P, WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
保存方法Shipped at 4°C. Store at +4°C.
バッファーPreservative: 0.02% Sodium azide
Concentration information loading...
Our Abpromise guarantee covers the use of ab8024 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||Use a concentration of 2 µg/ml.|
|WB||Use a concentration of 0.5 - 1 µg/ml.|
機能Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.
組織特異性Brain. Present in neurons within the hippocampus, frontal cortex and temporal cortex (at protein level). Expressed at low levels in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Expressed at low levels in the brain. Found in spinal cord, medulla oblongata, substantia nigra and locus coruleus. Expressed in the ductal epithelium of both normal and malignant prostate.
配列類似性Belongs to the peptidase A1 family.
翻訳後修飾Undergoes autoproteolytic cleavage.
細胞内局在Membrane. Golgi apparatus. Endoplasmic reticulum. Endosome. Cell surface.
- Information by UniProt
- ALP 56 antibody
- ALP56 antibody
- Asp 1 antibody
Western Blot of human heart lysate labeling BACE2 with Anti-BACE2 antibody (ab8024) at 1µg/ml in (1) the absence and (2) the presence of blocking peptide..
All lanes : Anti-BACE2 antibody (ab8024) at 1 µg/ml
Lane 1 : human heart tissue lysate with absence of blocking peptide
Lane 2 : human heart tissue lysate with presence of blocking peptide
Immunohistochemistry of BACE2 in rat heart tissue with BACE2 antibody at 2 µg/ml.