製品の概要

  • 製品名

    AS-041164, PI3K gamma inhibitor
  • 製品の詳細

    Potent and selective PI3Kγ inhibitor
  • 生理活性の詳細

    Potent PI3K inhibitor with selectivity for PI3Kγ (IC50 = 70 nM), compared to PI3Kα, β and δ (IC50 values are 240 nM, 1.45 and 1.70 μM, respectively). Shows little or no activity against 38 other common kinases. Blocks neutrophil migration. Active in vivo.
  • 精製度

    > 98%
  • CAS 番号

    1146702-72-8
  • 構造式

    Chemical Structure

製品の特性

参考文献

This product has been referenced in:

  • Ferrandi C  et al. Phosphoinositide 3-kinase gamma inhibition plays a crucial role in early steps of inflammation by blocking neutrophil recruitment. J Pharmacol Exp Ther 322:923-30 (2007). Read more (PubMed: 17526805) »

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