Aprepitant, hNK1 antagonist (ab269815)
Key features and details
- Potent and highly selective Neurokinin-1 (NK-1) receptor antagonist
- CAS Number: 170729-80-3
Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
Aprepitant, hNK1 antagonist -
製品の詳細
Potent and highly selective Neurokinin-1 (NK-1) receptor antagonist -
別名
- MK-0869
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生理活性の詳細
Potent (IC50 = 0.09nM; Ki = 19 pM), long-acting and highly selective Neurokinin-1 (NK-1) receptor antagonist. Inhibits Substance P activity. Antiemetic. CNS penetrant.
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CAS 番号
170729-80-3 -
構造式
製品の特性
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体系名
5-[[(2R,3S)-2-[(1R)-1-[3,5- Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4- morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one
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分子量
534.43 -
分子式
C23H21F7N4O3 -
PubChem 登録番号
135413536 -
保存方法
Shipped at room temperature. Store at -20°C. -
溶解性
Soluble in DMSO to 50 mM
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使用に関する注意
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[C@@H]2[C@@H](N(CCO2)CC3=NNC(=O)N3)C4=CC=C(C=C4)F -
由来
Synthetic
画像
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Chemical Structure - Aprepitant, hNK1 antagonist (ab269815)
Chemical structure of Aprepitant, hNK1 antagonist, 170729-80-3
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (0)
ab269815 は論文での使用が確認できていません。