Aphidicolin, DNA polymerase alpha, delta and epsilon inhibitor (ab142400)
Key features and details
- DNA polymerase α, δ and ε inhibitor
- CAS Number: 38966-21-1
- Purity: > 98%
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Phoma sp.
製品の概要
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製品名
Aphidicolin, DNA polymerase alpha, delta and epsilon inhibitor -
製品の詳細
DNA polymerase α, δ and ε inhibitor -
精製度
> 98% -
CAS 番号
38966-21-1 -
構造式
製品の特性
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体系名
(3R,4R,4aR,6aS,8R,9R,11aS,11bS)-4,9-bis(hydroxymethyl)-4,11b-dimethyltetradecahydro-8,11a-methanocyclohepta[a]naphthalene-3,9-diol -
分子量
338.48 -
分子式
C20H34O4 -
PubChem 登録番号
457964 -
保存方法
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 25 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CC12CCC(C(C1CCC3C24CCC(C(C3)C4)(CO)O)(C)CO)O -
由来
Phoma sp.
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研究分野
画像
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (9)
ab142400 は 9 報の論文で使用されています。
- Sun Y et al. RAD21 is the core subunit of the cohesin complex involved in directing genome organization. Genome Biol 24:155 (2023). PubMed: 37381036
- Grow EJ et al. p53 convergently activates Dux/DUX4 in embryonic stem cells and in facioscapulohumeral muscular dystrophy cell models. Nat Genet 53:1207-1220 (2021). PubMed: 34267371
- Wang H et al. Synergistic lethality between PARP-trapping and alantolactone-induced oxidative DNA damage in homologous recombination-proficient cancer cells. Oncogene 39:2905-2920 (2020). PubMed: 32029902
- Chen S et al. Nonrandom DNA Segregation Detection under Replication Stress. STAR Protoc 1:100143 (2020). PubMed: 33377037
- Watts LP et al. The RIF1-long splice variant promotes G1 phase 53BP1 nuclear bodies to protect against replication stress. Elife 9:N/A (2020). PubMed: 33141022
- Hu X et al. Region-Restrict Astrocytes Exhibit Heterogeneous Susceptibility to Neuronal Reprogramming. Stem Cell Reports 12:290-304 (2019). PubMed: 30713039
- Luo X et al. SUN1 Regulates HIV-1 Nuclear Import in a Manner Dependent on the Interaction between the Viral Capsid and Cellular Cyclophilin A. J Virol 92:N/A (2018). PubMed: 29643244
- Teng Y et al. ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB. Nat Commun 9:4115 (2018). PubMed: 30297739
- Xu Y et al. 53BP1 and BRCA1 control pathway choice for stalled replication restart. Elife 6:N/A (2017). PubMed: 29106372