Key features and details
- APC Armenian hamster monoclonal [MR1] to TRAP/CD40L
- Suitable for: Flow Cyt
- Reacts with: Mouse
- Conjugation: APC. Ex: 645nm, Em: 660nm
- Isotype: IgG
Related conjugates and formulations
製品名APC Anti-TRAP/CD40L antibody [MR1]
TRAP/CD40L 一次抗体 製品一覧
製品の詳細APC Armenian hamster monoclonal [MR1] to TRAP/CD40L
標識APC. Ex: 645nm, Em: 660nm
アプリケーション適用あり: Flow Cytmore details
Tissue, cells or virus corresponding to Mouse TRAP/CD40L. Activated Mouse Th1 clone D1.6
- Resting and 6-8 hour PMA or ionomicin-activated Mouse splenocytes.
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保存方法Shipped at 4°C. Store at +4°C.
Preservative: 0.09% Sodium azide
Concentration information loading...
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Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
機能Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching.
Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway.
組織特異性Specifically expressed on activated CD4+ T-lymphocytes.
関連疾患Defects in CD40LG are the cause of X-linked immunodeficiency with hyper-IgM type 1 (HIGM1) [MIM:308230]; also known as X-linked hyper IgM syndrome (XHIM). HIGM1 is an immunoglobulin isotype switch defect characterized by elevated concentrations of serum IgM and decreased amounts of all other isotypes. Affected males present at an early age (usually within the first year of life) recurrent bacterial and opportunistic infections, including Pneumocystis carinii pneumonia and intractable diarrhea due to cryptosporidium infection. Despite substitution treatment with intravenous immunoglobulin, the overall prognosis is rather poor, with a death rate of about 10% before adolescence.
配列類似性Belongs to the tumor necrosis factor family.
翻訳後修飾The soluble form derives from the membrane form by proteolytic processing.
N-linked glycan is a mixture of high mannose and complex type. Glycan structure does not influence binding affinity to CD40.
細胞内局在Secreted and Cell membrane.
- Information by UniProt
- CD 40L antibody
- CD154 antibody
- CD40 antigen ligand antibody