Anti-Amylin/DAP 抗体 (ab15125)
Key features and details
- Rabbit polyclonal to Amylin/DAP
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-Amylin/DAP antibody
Amylin/DAP 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Amylin/DAP -
由来種
Rabbit -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Human -
免疫原
Synthetic peptide within Human Amylin/DAP aa 1 to the C-terminus (N terminal). The exact sequence is proprietary.
Database link: P10997 -
ポジティブ･コントロール
- Pancreas.
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特記事項
This product is FOR RESEARCH USE ONLY. For commercial use, please contact partnerships@abcam.com.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7.60
Preservative: 0.1% Sodium azide
Constituents: PBS, 1% BSA -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab15125の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| IHC-P |
1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
1/200 for 10 min at RT. Boil tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min before commencing with IHC staining protocol. |
| 特記事項 |
|---|
|
IHC-P
1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. 1/200 for 10 min at RT. Boil tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min before commencing with IHC staining protocol. |
ターゲット情報
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機能
Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. -
配列類似性
Belongs to the calcitonin family. -
ドメイン
The mature protein is largely unstructured in the absence of a cognate ligand, and has a strong tendency to form fibrillar aggregates. Homodimerization may be the first step of amyloid formation. -
翻訳後修飾
Amyloid fibrils are degraded by IDE. -
細胞内局在
Secreted. - Information by UniProt
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参照データベース
- Entrez Gene: 3375 Human
- Omim: 147940 Human
- SwissProt: P10997 Human
- Unigene: 46835 Human
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別名
- Amylin antibody
- DAP antibody
- Diabetes associated peptide antibody
see all
画像
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Amylin/DAP antibody (ab15125)
ab15125 staining Amylin/DAP in human pancreas by Immunohistochemistry (Formalin/ PFA fixed paraffin embedded tissue sections).
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (4)
ab15125 は 4 報の論文で使用されています。
- Martinez-Valbuena I et al. Mixed pathologies in pancreatic ß cells from subjects with neurodegenerative diseases and their interaction with prion protein. Acta Neuropathol Commun 9:64 (2021). PubMed: 33832546
- Martinez-Valbuena I et al. Interaction of amyloidogenic proteins in pancreatic ß cells from subjects with synucleinopathies. Acta Neuropathol N/A:N/A (2018). IHC-P ; Human . PubMed: 29536165
- Ramzy A et al. Insulin-Deficient Mouse ß-Cells Do Not Fully Maturebut Can Be Remedied Through Insulin Replacementby Islet Transplantation. Endocrinology 159:83-102 (2018). PubMed: 29029025
- Suzuki H & Yamamoto T Amylin-like immunoreactivity in pancreatic X cells of the black-spotted frog Rana (Pelophylax) nigromaculata. Tissue Cell 46:535-9 (2014). IHC-Fr ; Frog . PubMed: 25458814