Anti-Alpha B Crystallin (phospho S45) 抗体 (ab5598)

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Western blot - Anti-Alpha B Crystallin (phospho S45) antibody (ab5598)

    Key features and details

    • Rabbit polyclonal to Alpha B Crystallin (phospho S45)
    • Suitable for: WB
    • Reacts with: Recombinant fragment
    • Isotype: IgG

    製品の概要

    • 製品名

      Anti-Alpha B Crystallin (phospho S45) antibody
      Alpha B Crystallin 一次抗体 製品一覧

    • 製品の詳細

      Rabbit polyclonal to Alpha B Crystallin (phospho S45)

    • 由来種

      Rabbit

    • アプリケーション

      適用あり: WBmore details

    • 種交差性

      交差種: Recombinant fragment
      交差が予測される動物種: Sheep, Rabbit, Hamster, Pig, Cynomolgus monkey

    • 免疫原

      Synthetic peptide corresponding to Human Alpha B Crystallin aa 44-54.
      Sequence: LSpPFYLRPPSF

      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

    • 特記事項

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    製品の特性

    アプリケーション

    The Abpromise guarantee

    Abpromise保証は、 次のテスト済みアプリケーションにおけるab5598の使用に適用されます

    アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。

    アプリケーション Abreviews 特記事項
    WB
    Use a concentration of 0.5 µg/ml. Detects a band of approximately 20 kDa.
    特記事項
    WB
    Use a concentration of 0.5 µg/ml. Detects a band of approximately 20 kDa.

    ターゲット情報

    • 機能

      May contribute to the transparency and refractive index of the lens.

    • 組織特異性

      Lens as well as other tissues.

    • 関連疾患

      Defects in CRYAB are the cause of myofibrillar alpha-B crystallin-related (MFM-CRYAB) [MIM:608810]. A neuromuscular disorder that results in weakness of the proximal and distal limb muscles, weakness of the neck, velopharynx and trunk muscles, hypetrophic cardiomyopathy, and cataract in a subset of patients.

    • 配列類似性

      Belongs to the small heat shock protein (HSP20) family.

    • 細胞内局在

      Cytoplasm. Nucleus. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.
    • Information by UniProt

    • 参照データベース

      • 別名

        • AACRYA antibody
        • Alpha B crystallin antibody
        • Alpha crystallin B chain antibody
        • Alpha(B)-crystallin antibody
        • Alpha-crystallin B chain antibody
        • CRYA2 antibody
        • Cryab antibody
        • CRYAB_HUMAN antibody
        • Crystallin alpha B antibody
        • Crystallin alpha polypeptide 2 antibody
        • CTPP2 antibody
        • Heat shock 20 kD like protein antibody
        • Heat shock protein beta 5 antibody
        • Heat shock protein beta-5 antibody
        • HspB5 antibody
        • Renal carcinoma antigen NY REN 27 antibody
        • Renal carcinoma antigen NY-REN-27 antibody
        • Rosenthal fiber component antibody
        see all

      画像

      • Western blot - Anti-Alpha B Crystallin (phospho S45) antibody (ab5598)
        Western blot - Anti-Alpha B Crystallin (phospho S45) antibody (ab5598)
        Western blot of recombinant bovine phospho-alpha-B crystallin (Ser45) using ab5598. Lane 1 is phospho-alpha-B crystallin (Ser45) and lane 2 is unphosphorylated alpha-B crystallin.

      参考文献 (2)

      ab5598 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

      ab5598 は 2 報の論文で使用されています。

      • Kuipers HF  et al. Phosphorylation of aB-crystallin supports reactive astrogliosis in demyelination. Proc Natl Acad Sci U S A 114:E1745-E1754 (2017). PubMed: 28196893
      • Tanito M  et al. Diagnostic Western blot for lens-specific proteins in aqueous fluid after traumatic lens-induced uveitis. Jpn J Ophthalmol 53:436-9 (2009). PubMed: 19763765

      レビューと Q&A

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      Question

      Dear sirs, our lab is currently using phospho alphaB-crystallin Abs but we are seriously considering to switch to different ones. Since we plan to spend a lot of money in these and other Abs, I would like to know if there could be any possibility to test the aB polyclonal Abs (total and 19/45/59 phosphorylated forms) before placing an order.

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      Answer

      Thank you for your enquiry. We do not routinely offer free or trial sized samples for testing purposes. Our policy at Abcam is that if an antibody does not work as specified on the datasheet, we will offer a replacement or reimbursement. Should you decide to test an antibody in an application for which we do not have any information, please let us know how you get on and in return we will award you 50 points with the Abcam Loyalty Scheme which can be redeemed on a number of rewards.

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