Key features and details
- Goat polyclonal to alpha 2 Macroglobulin (Biotin)
- Suitable for: Immunomicroscopy, IP, WB, Dot blot, ELISA, IHC-Fr
- Reacts with: Human
- Conjugation: Biotin
- Isotype: IgG
製品名Anti-alpha 2 Macroglobulin antibody (Biotin)
alpha 2 Macroglobulin 一次抗体 製品一覧
製品の詳細Goat polyclonal to alpha 2 Macroglobulin (Biotin)
アプリケーション適用あり: Immunomicroscopy, IP, WB, Dot blot, ELISA, IHC-Frmore details
Alpha-2-Macroglobulin [Human Plasma]
Biotinamidocaproate N-Hydroxysuccinimide Ester (BAC) Biotin/Protein Ratio: 10-20 BAC molecules per rabbit IgG molecule.
保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Preservative: 0.01% Sodium azide
Constituents: 0.88% Sodium chloride, 1% BSA, 0.42% Potassium phosphate
Concentration information loading...
特記事項（精製）This product is an IgG fraction antibody purified from monospecific antiserum by a multi-step process which includes delipidation, salt fractionation and ion exchange chromatography followed by extensive dialysis against the buffer.
Our Abpromise guarantee covers the use of ab7338 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ELISA (1:9,000 to 1:36,000)
as well as other antibody based assays using streptavidin or avidin conjugates requiring lot-to-lot consistency.
機能Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
組織特異性Secreted in plasma.
配列類似性Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
発生段階Contrary to the rat protein, which is an acute phase protein, this protein is always present at high levels in circulation.
- Information by UniProt
- A2m antibody
- A2MG_HUMAN antibody
- Alpha 2 M antibody
ab7338 は 1 報の論文で使用されています。
- Jensen PE et al. Significantly increased fractions of transformed to total alpha2-macroglobulin concentrations in plasma from patients with multiple sclerosis. Biochim Biophys Acta 1690:203-7 (2004). ELISA . PubMed: 15511627