Alexa Fluor® 700 Anti-CD41 抗体 [MEM-06] (ab270670)

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Flow Cytometry - Alexa Fluor® 700 Anti-CD41 antibody [MEM-06] (ab270670)
  • Flow Cytometry - Alexa Fluor® 700 Anti-CD41 antibody [MEM-06] (ab270670)

Key features and details

  • Alexa Fluor® 700 Mouse monoclonal [MEM-06] to CD41
  • Suitable for: Flow Cyt
  • Reacts with: Human
  • Conjugation: Alexa Fluor® 700
  • Isotype: IgG1

製品の概要

  • 製品名

    Alexa Fluor® 700 Anti-CD41 antibody [MEM-06]
    CD41 一次抗体 製品一覧

  • 製品の詳細

    Alexa Fluor® 700 Mouse monoclonal [MEM-06] to CD41

  • 由来種

    Mouse

  • 標識

    Alexa Fluor® 700

  • 特異性

    This antibody reacts with an extracellular epitope of CD41 (GPIIb), a transmembrane glycoprotein (integrin family) composed of two chains GPIIb alpha (heavy chain; 120 kDa) and GPIIb beta (light chain; 23 kDa). CD41 is mainly expressed on platelets and megakaryocytes.

  • アプリケーション

    適用あり: Flow Cytmore details

  • 種交差性

    交差種: Human

  • 免疫原

    Tissue, cells or virus corresponding to CD41. Leukocytes of patient suffering from LGL-type leukaemia.

  • ポジティブ･コントロール

    • Flow Cyt: Human peripheral whole blood.

  • 特記事項

    Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab270670 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Flow Cyt Use 4µl for 106 cells.

The reagent is designed for analysis of human blood cells using 4 μl reagent / 100 μl of whole blood or 106 cells in a suspension.

 

ターゲット情報

  • 機能

    Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.

  • 組織特異性

    Isoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in reticulocytes or in Jurkat and U937 white blood cell line. Isoform 3 is expressed by leukemia, prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells.

  • 関連疾患

    Defects in ITGA2B are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as thrombasthenia of Glanzmann and Naegeli. GT is the most common inherited disease of platelets. It is an autosomal recessive disorder characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb/beta-3 complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the glycoprotein IIb/beta-3 complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT 'variants' have normal or near normal (60-100%) expression of dysfunctional receptors.

  • 配列類似性

    Belongs to the integrin alpha chain family.
    Contains 7 FG-GAP repeats.

  • 細胞内局在

    Membrane.
  • Information by UniProt

  • 参照データベース

    • 別名

      • antigen CD41 antibody
      • BDPLT16 antibody
      • BDPLT2 antibody
      • CD41 antibody
      • CD41B antibody
      • form 2 antibody
      • GP2B antibody
      • GPalpha IIb antibody
      • GPIIb antibody
      • GT antibody
      • GTA antibody
      • HPA3 antibody
      • Integrin alpha 2b antibody
      • Integrin alpha IIb antibody
      • Integrin alpha-IIb light chain antibody
      • Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) antibody
      • ITA2B_HUMAN antibody
      • Itga2b antibody
      • ITGAB antibody
      • platelet fibrinogen receptor, alpha subunit antibody
      • platelet glycoprotein IIb of IIb/IIIa complex antibody
      • Platelet membrane glycoprotein IIb antibody
      • platelet specific antigen BAK antibody
      • PPP1R93 antibody
      see all

    画像

    • Flow Cytometry - Alexa Fluor® 700 Anti-CD41 antibody [MEM-06] (ab270670)
      Flow Cytometry - Alexa Fluor® 700 Anti-CD41 antibody [MEM-06] (ab270670)

      Flow cytometry analysis of human peripheral whole blood labeling CD41 positive thrombocytes (Red) using ab270670. Surface staining.

      Control: CD41 negative lymphocytes (Black).

    • Flow Cytometry - Alexa Fluor® 700 Anti-CD41 antibody [MEM-06] (ab270670)
      Flow Cytometry - Alexa Fluor® 700 Anti-CD41 antibody [MEM-06] (ab270670)

      Flow cytometry analysis of human peripheral whole blood labeling CD41 using ab270670. Surface staining.

    プロトコール

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    参考文献 (0)

    ab270670 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab270670 は論文での使用が確認できていません。

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