ACC2 Inhibitor, ACC2 (Acetyl-CoA Carboxylase) inhibitor (ab142090)

製品の概要

  • 製品名

    ACC2 Inhibitor, ACC2 (Acetyl-CoA Carboxylase) inhibitor
  • 製品の詳細

    Potent, selective ACC2 (Acetyl-CoA Carboxylase) inhibitor
  • 生理活性の詳細

    Potent, selective ACC2 (Acetyl-CoA Carboxylase) inhibitor (IC50 values are 28 and 210 nM for hACC2 and hACC1 respectively). Active in vivo and in vitro.
  • 精製度

    > 98%
  • 構造式

    Chemical Structure

製品の特性

  • 体系名

    N-(1-(2'-(4-Isopropoxyphenoxy)-2,5'-bithiazol-5-yl)ethyl)acetamide
  • 分子量

    403.52
  • 分子式

    C19H21N3O3S2
  • 保存方法

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • 溶解性

    Soluble in DMSO
  • 使用に関する注意

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES 線形表記

    CC(=O)NC(C)c1cnc(s1)c3cnc(Oc2ccc(OC(C)C)cc2)s3
  • 由来

    Synthetic

  • 研究分野

参考文献

This product has been referenced in:

  • Rajamohan F  et al. Structure-guided inhibitor design for human acetyl-coenzyme A carboxylase by interspecies active site conversion. J Biol Chem 286:41510-9 (2011). Read more (PubMed: 21953464) »
  • Keil S  et al. Identification and synthesis of novel inhibitors of acetyl-CoA carboxylase with in vitro and in vivo efficacy on fat oxidation. J Med Chem 53:8679-87 (2010). Read more (PubMed: 21082864) »
  • Corbett JW Review of recent acetyl-CoA carboxylase inhibitor patents: mid-2007-2008. Expert Opin Ther Pat 19:943-56 (2009). Read more (PubMed: 19552511) »

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