Anti-EPCR/CD201 抗体 [RCR-252] (ab81712)
Key features and details
- Rat monoclonal [RCR-252] to EPCR/CD201
- Suitable for: Flow Cyt
- Reacts with: Human
- Isotype: IgG1
製品の概要
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製品名
Anti-EPCR/CD201 antibody [RCR-252]
EPCR/CD201 一次抗体 製品一覧 -
製品の詳細
Rat monoclonal [RCR-252] to EPCR/CD201 -
由来種
Rat -
アプリケーション
適用あり: Flow Cytmore details -
種交差性
交差種: Human -
免疫原
Tissue, cells or virus. This information is proprietary to Abcam and/or its suppliers.
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エピトープ
Antibody RCR-252 stains the extracellular domain of human EPCR. -
ポジティブ・コントロール
- Flow Cyt: HUVEC cells.
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特記事項
Ablates APC binding to EPCR/CD201 thus blocking APC-mediated signalling.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
Constituents: 0.1% BSA, PBS -
Concentration information loading...
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精製度
Protein A purified -
特記事項(精製)
0.2µM filtered -
一次抗体 備考
Ablates APC binding to EPCR/CD201 thus blocking APC-mediated signalling. -
ポリ/モノ
モノクローナル -
クローン名
RCR-252 -
アイソタイプ
IgG1 -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab81712の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
Flow Cyt |
1/50.
ab18407 - Rat monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
特記事項 |
---|
Flow Cyt
1/50. ab18407 - Rat monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
ターゲット情報
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機能
Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation. -
組織特異性
Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney. -
翻訳後修飾
N-glycosylated.
A soluble form exists; probably released by a metalloprotease. Seems to have the same activity as the membrane-bound form. -
細胞内局在
Membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 10544 Human
- Omim: 600646 Human
- SwissProt: Q9UNN8 Human
- Unigene: 647450 Human
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別名
- Activated protein C receptor antibody
- APC receptor antibody
- APCR antibody
see all
画像
データシートおよび資料
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Datasheet download
参考文献 (5)
ab81712 は 5 報の論文で使用されています。
- Mutoh T et al. Identification of two major autoantigens negatively regulating endothelial activation in Takayasu arteritis. Nat Commun 11:1253 (2020). PubMed: 32152303
- Janssen A et al. ?d T-cell Receptors Derived from Breast Cancer-Infiltrating T Lymphocytes Mediate Antitumor Reactivity. Cancer Immunol Res 8:530-543 (2020). PubMed: 32019779
- Healy LD et al. Activated protein C inhibits neutrophil extracellular trap formation in vitro and activation in vivo. J Biol Chem 292:8616-8629 (2017). PubMed: 28408624
- Dömötör E et al. Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1. Blood 101:4797-801 (2003). Inhibition Assay ; Human . PubMed: 12586611
- Sturn DH et al. Expression and function of the endothelial protein C receptor in human neutrophils. Blood 102:1499-505 (2003). Flow Cyt ; Human . PubMed: 12714492