Anti-TMEM16A 抗体 [DG1/447] (ab190721)
Key features and details
- Mouse monoclonal [DG1/447] to TMEM16A
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG1
製品の概要
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製品名
Anti-TMEM16A antibody [DG1/447]
TMEM16A 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [DG1/447] to TMEM16A -
由来種
Mouse -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Human -
免疫原
Recombinant full length protein corresponding to Human TMEM16A aa 1 to the C-terminus.
Database link: Q5XXA6 -
ポジティブ・コントロール
- IHC-P: Human gastrointestinal stromal tumor tissue.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
バッファー
pH: 7.2
Preservative: 0.05% Sodium azide
Constituents: 0.05% BSA, PBS -
Concentration information loading...
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精製度
Protein A/G purified -
ポリ/モノ
モノクローナル -
クローン名
DG1447 -
アイソタイプ
IgG1 -
軽鎖の種類
kappa -
研究分野
関連製品
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Alternative Versions
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab190721の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IHC-P | (2) |
Use a concentration of 1 - 2 µg/ml. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
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特記事項 |
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IHC-P
Use a concentration of 1 - 2 µg/ml. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol. |
ターゲット情報
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機能
Acts as a calcium-activated chloride channel. Required for normal tracheal development. -
組織特異性
Broadly expressed with higher levels in liver and skeletal muscle. -
配列類似性
Belongs to the anoctamin family. -
ドメイン
The region spanning the fifth and sixth transmembrane domains probably forms the pore-forming region. -
細胞内局在
Cell membrane. Cytoplasm. - Information by UniProt
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参照データベース
- Entrez Gene: 55107 Human
- Omim: 610108 Human
- SwissProt: Q5XXA6 Human
- Unigene: 503074 Human
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別名
- ANO 1 antibody
- ANO1 antibody
- ANO1_HUMAN antibody
see all
画像
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (4)
ab190721 は 4 報の論文で使用されています。
- Yoon H et al. TGF-ß1-mediated transition of resident fibroblasts to cancer-associated fibroblasts promotes cancer metastasis in gastrointestinal stromal tumor. Oncogenesis 10:13 (2021). PubMed: 33568624
- Samuel RZ et al. Engineering the mode of morphogenetic signal presentation to promote branching from salivary gland spheroids in 3D hydrogels. Acta Biomater 105:121-130 (2020). PubMed: 31988042
- Chai RR et al. Prohibitin involvement in the generation of mitochondrial superoxide at complex I in human sperm. J Cell Mol Med 21:121-129 (2017). PubMed: 27558591
- Klaka P et al. A novel organotypic 3D sweat gland model with physiological functionality. PLoS One 12:e0182752 (2017). PubMed: 28796813