Kainic acid (mM/ml), Prototypic kainate receptor agonist (ab144490)
Key features and details
- Prototypic kainate receptor agonist. 1 ml water soluble pack.
- CAS Number: 487-79-6
- Purity: > 99%
- Soluble in 1ml of water to give specified mM/ml concentration
- Form / State: Solid
- Source: Digenea simplex
製品の概要
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製品名
Kainic acid (mM/ml), Prototypic kainate receptor agonist -
製品の詳細
Prototypic kainate receptor agonist. 1 ml water soluble pack. -
別名
- Kainate
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生理活性の詳細
Prototypic agonist at the kainate class of ionotropic glutamate receptors. Potent excitant and neurotoxin, used to model epilepsy and neurodegenerative states.
Soluble in 1 ml water to give specified mM/ml concentration. Find out more. -
精製度
> 99% -
CAS 番号
487-79-6 -
構造式
製品の特性
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体系名
(2S,3S,4S)-3-(Carboxymethyl)-4-(prop-1-en-2-yl)pyrrolidine-2-carboxylic acid -
分子量
213.23 -
分子式
C10H15NO4 -
PubChem 登録番号
10255 -
保存方法
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in 1ml of water to give specified mM/ml concentration -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CC(=C)[C@H]1CN[C@@H]([C@H]1CC(=O)O)C(=O)O -
由来
Digenea simplex
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研究分野
画像
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2D chemical structure image of ab144490, Kainic acid (mM/ml), Prototypic kainate receptor agonist
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Immunocytochemistry/ Immunofluorescence analysis of microglial cells in the stratum radiatum of the CA1 region of the hippocampus of CX3CR1egfp/+ mice in control conditions (left) or 48 hours after status epilepticus (SE) induced by intra-peritoneal injection of kainate (right). Each image is a maximum intensity z-projection of 31 confocal slices for a total thickness of 12 µm.
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (34)
ab144490 は 34 報の論文で使用されています。
- Henry KS & Abrams KS Normal Tone-In-Noise Sensitivity in Trained Budgerigars despite Substantial Auditory-Nerve Injury: No Evidence of Hidden Hearing Loss. J Neurosci 41:118-129 (2021). PubMed: 33177067
- Taga A et al. Establishment of an Electrophysiological Platform for Modeling ALS with Regionally-Specific Human Pluripotent Stem Cell-Derived Astrocytes and Neurons. J Vis Exp N/A:N/A (2021). PubMed: 34515684
- Wong SJ et al. Effects of selective auditory-nerve damage on the behavioral audiogram and temporal integration in the budgerigar. Hear Res 374:24-34 (2019). PubMed: 30703625
- Tischbein M et al. The RNA-binding protein FUS/TLS undergoes calcium-mediated nuclear egress during excitotoxic stress and is required for GRIA2 mRNA processing. J Biol Chem 294:10194-10210 (2019). PubMed: 31092554
- Shi C et al. Melatonin Mitigates Kainic Acid-Induced Neuronal Tau Hyperphosphorylation and Memory Deficits through Alleviating ER Stress. Front Mol Neurosci 11:5 (2018). PubMed: 29416502