(+)-Nutlin-3, p53-MDM2 binding inhibitor (ab144426)
Key features and details
- p53-MDM2 binding inhibitor
- CAS Number: 548472-68-0
- Purity: > 98%
- Soluble in DMSO
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
(+)-Nutlin-3, p53-MDM2 binding inhibitor -
製品の詳細
p53-MDM2 binding inhibitor -
生理活性の詳細
p53-MDM2 binding inhibitor (IC50 = 13 μM). Less potent enantiomer of (-)-Nutlin-3 (Asc-4428). Shows antiproliferative effects (IC50 values are 2.2 and 1.3 µM for human skin and murine fibroblasts respectively). Shows antitumor effects in vivo. Orally active. -
精製度
> 98% -
CAS 番号
548472-68-0 -
構造式
製品の特性
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体系名
4-[(4R,5S)-4,5-Bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one -
分子量
581.50 -
分子式
C30H30Cl2N4O4 -
PubChem 登録番号
16755649 -
保存方法
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CC(C)OC1=C(C=CC(=C1)OC)C2=N[C@@H]([C@@H](N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl -
由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (0)
ab144426 は論文での使用が確認できていません。