Batimastat (BB-94), Matrix metalloprotease (MMP) inhibitor (ab142087)
Key features and details
- Potent, broad-spectrum MMP inhibitor
- CAS Number: 130370-60-4
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
Batimastat (BB-94), Matrix metalloprotease (MMP) inhibitor -
製品の詳細
Potent, broad-spectrum MMP inhibitor -
生理活性の詳細
Potent, broad-spectrum MMP inhibitor (IC50 values are 3 (MMP-1), 4 (MMP-2), 4 (MMP-9), 6 (MMP-7), 20 nM (MMP-3)). Anticancer activity in vivo.
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精製度
> 98% -
CAS 番号
130370-60-4 -
構造式
製品の特性
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体系名
(2R,3S)-N4-Hydroxy-N1-[(1S)-2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]butanediamide -
分子量
477.64 -
分子式
C23H31N3O4S2 -
PubChem 登録番号
5362422 -
保存方法
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CC(C)CC(C(CSC1=CC=CS1)C(=O)NO)C(=O)NC(CC2=CC=CC=C2)C(=O)NC -
由来
Synthetic
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研究分野
画像
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (7)
ab142087 は 7 報の論文で使用されています。
- Brauer E et al. Dissecting the influence of cellular senescence on cell mechanics and extracellular matrix formation in vitro. Aging Cell 22:e13744 (2023). PubMed: 36514868
- Keppie SJ et al. Matrix-Bound Growth Factors are Released upon Cartilage Compression by an Aggrecan-Dependent Sodium Flux that is Lost in Osteoarthritis. Function (Oxf) 2:zqab037 (2021). PubMed: 34423304
- Ambite I et al. Molecular Basis of Acute Cystitis Reveals Susceptibility Genes and Immunotherapeutic Targets. PLoS Pathog 12:e1005848 (2016). PubMed: 27732661
- Paschkowsky S et al. Alternative Processing of the Amyloid Precursor Protein Family by Rhomboid Protease RHBDL4. J Biol Chem 291:21903-21912 (2016). PubMed: 27563067
- McColl R et al. Analysis and quantification of in vitro myoblast fusion using the LADD Multiple Stain. Biotechniques 61:323-326 (2016). PubMed: 27938324
- Cremasco V et al. B cell homeostasis and follicle confines are governed by fibroblastic reticular cells. Nat Immunol 15:973-81 (2014). PubMed: 25151489
- Beltramo E et al. Extracellular vesicles derived from mesenchymal stem cells induce features of diabetic retinopathy in vitro. Acta Diabetol 51:1055-64 (2014). PubMed: 25374383