Jasplakinolide, Actin polymerization and stabilization inducer (ab141409)
Key features and details
- Actin polymerization and stabilization inducer. Cell-permeable.
- CAS Number: 102396-24-7
- Purity: > 95%
- Soluble in DMSO
- Form / State: Solid
- Source: Jaspis splendens
製品の概要
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製品名
Jasplakinolide, Actin polymerization and stabilization inducer -
製品の詳細
Actin polymerization and stabilization inducer. Cell-permeable. -
生理活性の詳細
Cell-permeable actin polymerization and stabilization inducer. Potent antiproliferative activity (IC50 = 15 nM). Antitumor and antifungal agent. Active in vitro.
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精製度
> 95% -
CAS 番号
102396-24-7 -
構造式
製品の特性
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体系名
Cyclo[(3R)-3-(4-hydroxyphenyl)-β-alanyl-(2S,4E,6R,8S)-8-hydroxy-2,4,6-
trimethyl-4-nonenoyl-L-alanyl-2-bromo-N-methyl-D-tryptophyl] -
分子量
709.68 -
分子式
C36H45BrN4O6 -
PubChem 登録番号
6436289 -
保存方法
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
C[C@@H]\1C[C@@H](OC(=O)C[C@@H](NC(=O)[C@H](N(C(=O)[C@@H](NC(=O)[C@@H](C/C(=C1)/C)C)C)C)CC2=C(NC3=CC=CC=C32)Br)C4=CC=C(C=C4)O)C -
由来
Jaspis splendens
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研究分野
画像
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (13)
ab141409 は 13 報の論文で使用されています。
- He S et al. Tensile Overload Injures Human Alveolar Epithelial Cells through YAP/F-Actin/MAPK Signaling. Biomedicines 11:N/A (2023). PubMed: 37509472
- Sai X et al. Planar cell polarity-dependent asymmetric organization of microtubules for polarized positioning of the basal body in node cells. Development 149:N/A (2022). PubMed: 35420656
- Ma L et al. SGLT2 inhibitor dapagliflozin reduces endothelial dysfunction and microvascular damage during cardiac ischemia/reperfusion injury through normalizing the XO-SERCA2-CaMKII-coffilin pathways. Theranostics 12:5034-5050 (2022). PubMed: 35836807
- Kepser LJ et al. Cyclase-associated protein 2 (CAP2) controls MRTF-A localization and SRF activity in mouse embryonic fibroblasts. Sci Rep 11:4789 (2021). PubMed: 33637797
- Yeung ML et al. Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system. Cell 184:2212-2228.e12 (2021). PubMed: 33713620