Kainic acid, prototypic kainate receptor agonist (ab120100)
Key features and details
- Prototypic kainate receptor agonist
- CAS Number: 487-79-6
- Soluble in water to 25 mM
- Form / State: Solid
- Source: Digenea simplex
製品の概要
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製品名
Kainic acid, prototypic kainate receptor agonist -
製品の詳細
Prototypic kainate receptor agonist -
別名
- Kainate
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生理活性の詳細
Prototypic agonist at the kainate class of ionotropic glutamate receptors. Potent excitant and neurotoxin, used to model epilepsy and neurodegenerative states. Also available in Kit(s): Ionotropic agonists (ab120323).
Also available in simple stock solutions (ab144490) - add 1 ml of water to get an exact, ready-to-use concentration. -
CAS 番号
487-79-6 -
構造式
製品の特性
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体系名
(2S,3S,4S)-3-(Carboxymethyl)-4-(prop-1-en-2-yl)pyrrolidine-2-carboxylic acid -
分子量
213.23 -
分子式
C10H15NO4 -
PubChem 登録番号
10255 -
保存方法
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in water to 25 mM -
使用に関する注意
This product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and information page for more details on handling.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CC(=C)[C@H]1CN[C@@H]([C@H]1CC(=O)O)C(=O)O -
由来
Digenea simplex
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研究分野
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab120100の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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Functional Studies |
Use at an assay dependent concentration.
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特記事項 |
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Functional Studies
Use at an assay dependent concentration. |
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (67)
ab120100 は 67 報の論文で使用されています。
- Melin E et al. Combinatorial gene therapy for epilepsy: Gene sequence positioning and AAV serotype influence expression and inhibitory effect on seizures. Gene Ther 30:649-658 (2023). PubMed: 37029201
- Fan J et al. Preferential pruning of inhibitory synapses by microglia contributes to alteration of the balance between excitatory and inhibitory synapses in the hippocampus in temporal lobe epilepsy. CNS Neurosci Ther 29:2884-2900 (2023). PubMed: 37072932
- Wu J et al. Principal neurons in the olfactory cortex mediate bidirectional modulation of seizures. J Physiol 601:3557-3584 (2023). PubMed: 37384845
- Špirková A et al. Glutamate can act as a signaling molecule in mouse preimplantation embryos†. Biol Reprod 107:916-927 (2022). PubMed: 35746896
- Fei F et al. Discrete subicular circuits control generalization of hippocampal seizures. Nat Commun 13:5010 (2022). PubMed: 36008421