Key features and details
- Purity: > 95% HPLC
- Suitable for: Blocking
AANAT タンパク質・ペプチド 製品一覧
精製度> 95 % HPLC.
Peptides are analyzed by Reverse-Phase HPLC (RP-HPLC) in order to determine purity. Identities are confirmed by MALDI-MS.
Our Abpromise guarantee covers the use of ab5003 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and AA-NAT, catalog ab3505. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.
This product was previously labelled as Serotonin N-acetyltransferase
Concentration information loading...
Shipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
再構成>95% pure, lyophilized synthetic peptide. Reconstitute with 0.1 ml of distilled water.
- Aralkylamine N-acetyltransferase
機能Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin.
組織特異性Highly expressed in pineal gland and at lower levels in the retina. Weak expression in several brain regions and in the pituitary gland.
パスウェイAromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2.
関連疾患Delayed sleep phase syndrome
配列類似性Belongs to the acetyltransferase family. AANAT subfamily.
Contains 1 N-acetyltransferase domain.
翻訳後修飾cAMP-dependent phosphorylation on both N-terminal Thr-31 and C-terminal Ser-205 regulates AANAT activity by promoting interaction with 14-3-3 proteins.
- Information by UniProt
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab5003 は 1 報の論文で使用されています。
- Lu H et al. DNA-PKcs promotes chromatin decondensation to facilitate initiation of the DNA damage response. Nucleic Acids Res 47:9467-9479 (2019). PubMed: 31396623